Navigation Links
Space Research May Help Explain Salmonella Illness
Date:3/11/2009

HOUSTON, March 11 /PRNewswire-USNewswire/ -- Salmonella bacteria research from two recent NASA space missions discovered key elements of the bacteria's disease-causing potential that hold promise for improving ways to fight food-borne infections on Earth.

(Logo: http://www.newscom.com/cgi-bin/prnh/20081007/38461LOGO )

Salmonella is a leading cause of food poisoning and related illnesses. According to the Centers for Disease Control and Prevention, approximately 40,000 cases of Salmonella infections are reported in the United States each year.

"This research opens up new areas for investigations that may improve food treatment, develop new therapies and vaccines to combat food poisoning in humans here on Earth, and protect astronauts on orbit from infectious disease," said Julie Robinson, program scientist for the International Space Station at NASA's Johnson Space Center in Houston.

The Salmonella experiments were flown on shuttle missions to the International Space Station in September 2006 and March 2008.

The 2006 experiment results allowed researchers to identify a molecular "switch" that appears to control Salmonella's response to spaceflight in unique ways not observed using traditional experimental approaches on Earth. The 2006 results showed that the space environment causes a short-term alteration in Salmonella virulence -- the bacteria cultured in space were more virulent than those on Earth.

The 2008 experiment confirmed the 2006 results and demonstrated that a change in the growth environment of the bacteria controls its virulence. There is no evidence that the space-grown bacteria sustained these effects for long periods after returning to Earth.

In addition to finding a leading candidate as to why the bacteria becomes more virulent in space, results from the 2008 experiment helped researchers identify ways to counter the virulence effect. A research team led by Cheryl Nickerson of the Biodesign Institute at Arizona State University in Tempe found that adjusting the ion content of the bacteria's environment can turn off the rise in virulence caused by spaceflight.

The space experiments helped researchers show that a mechanical force known as "fluid shear," the motion of fluid that cells sense as fluid passes over their surface, could have a dramatic effect on Salmonella's disease-causing potential.

Lower fluid shear conditions, it turns out, are found both in microgravity and in our intestines. The bacteria cultured in space are more virulent, and Nickerson's work showed that by modifying the medium in which the cells are grown, the virulence could be reduced, or turned off.

In other words, space travel may trick the bacteria into behaving as though they were in the low fluid shear environment of the intestine, essentially turning on a switch inside the microbe that increases virulence. Changing the chemistry of the medium in which the bacteria are cultured reverses this effect.

"To our knowledge, no one had previously looked at a mechanical force like fluid shear on the disease-causing properties of a microorganism during the infection process," Nickerson said. "We can use the innovative research platform of the space station to contribute to new translational advances for the development of new strategies to globally advance human health."

The experiments were managed by NASA's Ames Research Center at Moffett Field, Calif., in support of NASA's Exploration Systems Mission Directorate. The Nickerson team's initial findings were published in the Proceedings of the National Academy of Sciences, and their most recent findings published in the journal PLoS ONE.

For more about the Salmonella research conducted in space, visit:

http://www.nasa.gov/mission_pages/station/science/experiments/MDRV.html

For more about other ongoing scientific experiments on the space station, visit:

http://www.nasa.gov/mission_pages/station/science/index.html

For more about the Space Shuttle Program, visit:

http://www.nasa.gov/shuttle


'/>"/>
SOURCE NASA
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. BioSpace to Power 2009 BIO Career Fair
2. DeviceSpace and Medical Device Link Launch Dynamic, Online Career Center
3. Coalition for Space Exploration Salutes American Heart Month
4. Globus Medicals SIGNATURE(TM) Spacer Designed for MILDER(TM) TLIF Procedures
5. CSC Introduces HealthSpace Advisor Benchmarking Tool
6. Astronauts on International Space Station lose alarming amounts of hipbone strength
7. New Programmable System is First to Continually Sanitize the Air in HVAC Ducts and Commercial, Medical and Residential Spaces
8. From outer space to the eye clinic: New cataract early detection technique
9. MAQUET Opens North Americas First VARIOP Prefabricated Operating Suite System, Allowing Space Reconfiguration in Hours, Less Disruption Than Traditional Construction
10. Watching water from space could aid disease prevention in China
11. Nurture(R) by Steelcase Wins Second Consecutive Nightingale Award for SYNC(TM) Caregiver Workspace Solution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... ... 2016 , ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover of ... was inspired to practice medicine at an early age by his father, who was ... diagnoses and prescribing medicine,” he states. “It is about building relationships with people; relationships ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... two ostomy patients, standing as living proof that attitude and determination can combine ... and issues that spike around the holidays. This campaign will offer patients a ...
(Date:12/2/2016)... ... December 02, 2016 , ... More than half of American teens report losing ... report speaking with their child about sex related topics, less than 60 percent spoke ... proud to announce the launch of its second edition of the “Sexual Wellness” campaign, ...
(Date:12/2/2016)... ... 02, 2016 , ... CloudLIMS.com, a class-leading provider of Laboratory ... CloudLIMS Lite helps biobanks, clinical, research and testing laboratories keep track of their ... version is a faster and a more efficient product, allowing batch processing of ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- UCB is pleased to announce that 12 scientific abstracts have ... American Epilepsy Society (AES) Annual Meeting, which takes place ... USA. 1-12 Data being presented include ... ® (lacosamide) CV and BRIVIACT ® (brivaracetam) CV. ... state of the union of epilepsy care and antiepileptic drugs ...
(Date:12/2/2016)... -- Allergan plc (NYSE: AGN ), a leading ... announced Accelerated Share Repurchase (ASR) Program. Logo - ... , ... announced, the Company entered into a variable tenor ASR arrangement ... $10 billion of its ordinary shares. Approximately 40.5 million shares ...
(Date:11/30/2016)... , Nov 30, 2016 Research and ... Intracranial Pressure Monitoring Devices 2017 - MedCore" report to their offering. ... , , ... brain and the skull. In healthy individuals, it is circulated though the ... are cases where the amount of CSF surrounding the brain changes significantly. ...
Breaking Medicine Technology: