Navigation Links
Soy increases radiation's ability to kill lung cancer cells, study shows
Date:3/31/2011

A component in soybeans increases radiation's ability to kill lung cancer cells, according to a study published in the April issue of the Journal of Thoracic Oncology, the official monthly journal of the International Association for the Study of Lung Cancer.

"To improve radiotherapy for lung cancer cells, we are studying the potential of natural non-toxic components of soybeans, called soy isoflavones, to augment the effect of radiation against the tumor cells and at the same time protect normal lung against radiation injury," said Dr. Gilda Hillman, an associate professor in the Department of Radiation Oncology at Wayne State University's School of Medicine and the Karmanos Cancer Institute in Detroit.

"These natural soy isoflavones can sensitize cancer cells to the effects of radiotherapy, by inhibiting survival mechanisms which cancer cells activate to protect themselves," Hillman said. "At the same time, soy isoflavones can also act as antioxidants in normal tissues, which protect them against unintended damage from the radiotherapy. In a recent study, published in the Journal of Thoracic Oncology, we demonstrated that soy isoflavones increase killing of cancer cells by radiation via blocking DNA repair mechanisms, which are turned on by the cancer cells to survive the damage caused by radiation."

Human A549 non-small cell lung cancer (NSCLC) cells that were treated with soy isoflavones before radiation showed more DNA damage and less repair activity than cells that received only radiation.

Researchers used a formulation consisting of the three main isoflavones found in soybeans, including genistein, daidzein and glycitein.

Previously, researchers had found that pure genistein demonstrated antitumor activity in human NSCLC cell lines and enhanced the effects of EGFR-tyrosine kinase inhibitors. This study showed that the soy mixture had an even greater antitumor effect than pure genistein. The soy mixture also is consistent with the soy isoflavone pills used in clinical studies, which have been proven to be safe, researchers said.


'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Risk of hospital patient mortality increases with nurse staffing shortfalls, study finds
2. Passive smoking increases risk to unborn babies, study says
3. As Peer Pressure Increases, So Does Brains Ability to Resist It
4. Red wine compound increases anti-tumor effect of rapamycin
5. University Hospitals system-approach to stroke care increases the use of tPA therapy by 13.5-fold
6. Cocaine production increases destruction of Colombias rainforests
7. Risk of cancer increases with exposure to low-dose radiation
8. Low socioeconomic status increases depression risk in rheumatoid arthritis patients
9. Adult ADHD significantly increases risk of common form of dementia
10. Study shows that CPAP therapy reduces fatigue, increases energy in patients with sleep apnea
11. New research: Un-growth hormone increases longevity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 16, 2017 , ... St. Louisans are well-aware of the following facts at present:, ... influenza shot seems to be having no effect on keeping this particularly bad strain of ... people around are coughing, sneezing, or sniffling , These facts are well-known ...
(Date:1/16/2017)... ... January 16, 2017 , ... Board-certified oculoplastic surgeon Dr. Mehryar ... official journal of The American Society for Aesthetic Plastic Surgery, in which he ... designed to correct drooping, retracted lower eyelids, which usually result from genetics, injury, ...
(Date:1/16/2017)... ... , ... One thing common to all types of cancer is that it’s ... The money spent screening for and treating cancer in the United States is estimated ... more than in any other country that has an advanced healthcare system, sometimes spending ...
(Date:1/16/2017)... , ... January 16, 2017 , ... ... been appointed Chief Executive Officer of the medical device company, effective immediately. , ... Robert Storey. “Kevin has a strong track record in medical device market ...
(Date:1/15/2017)... New York, NY (PRWEB) , ... January 15, 2017 , ... ... growing strategic accounts in the United States for the asthma & allergy friendly mark. ... of America to independently test and identify consumer products to be more suitable for ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... -- The global pacemaker market is expected to reach ... report by Grand View Research, Inc. The heightening prevalence ... coverage is a key driving factor governing the growth ... devices are supporting the expansion of this vertical. ... growth rendering driver for this market. A death estimate ...
(Date:1/16/2017)... , Jan. 16, 2017 Derek H. ... Law Firm, was recently appointed Liaison Counsel in ... for all Xarelto cases. In this role, Potts was ... and will actively assist the Court and Co Lead ... Milstein Adelman Jackson Fairchild & Wade ...
(Date:1/16/2017)...  Harrington Discovery Institute at University Hospitals in ... of The Harrington Project for Discovery & Development ... in collaboration with Alzheimer,s Drug Discovery Foundation (ADDF), ... Harrington Discovery Institute collaborations are ... into new medicines that will improve human health, ...
Breaking Medicine Technology: