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Soy-based compound may reduce tumor cell proliferation in colorectal cancer
Date:4/11/2013

vatars to directly test KPT-330 provided by Karyopharm Therapeutics.

"This is truly a translational research initiative where our own Mount Sinai patients are simultaneously contributing to a potential next generation therapy for incurable ovarian cancer and gaining insight into personalized treatment of their own cancers," said Dr. Martignetti. "These results show that new oral XPO1 inhibitors may be quite promising in treating patients who do not respond to, or relapse after, treatment with platinum-based therapy. We look forward to evaluating oral KPT-330 in our patients."

These studies were in part funded through a gift from Sally and Michael Gordon, a gift from Varadi Ovarian Cancer Research Program at Mount Sinai, and a research grant from Karyopharm Therapeutics.

  • Researchers Identify New Drug Target for Prostate Cancer

During cancer progression, cancer cells constantly interact with and modify their surrounding tumor microenvironment through regulating the expression of a group of enzyme inhibitors called tissue inhibitors of metalloproteinases (TIMPs). Previously, William Oh, MD, Professor and Chief of the Division of Hematology/Oncology in the department of Medicine at Mount Sinai and his colleagues showed that elevated TIMP-1 levels in the blood predicted decreased survival in advanced prostate cancer patients. However, the regulation of TIMP-1 expression in prostate cancer was not fully understood and the source of TIMP-1 overproduction remains unknown.

In the current study led by Yixuan Gong, PhD, in Dr. Oh's lab, the researchers show for the first time that resistance to androgen therapy, the most common treatment for prostate cancer, was associated with TIMP-1 overproduction in both prostate cancer patients and in cell culture models. They found that two signaling pathways called MEK and NF-ĸB were critical for TIMP-1 production in certain prostate cells and the production could be com
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Source:Eurekalert

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