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Soy-based compound may reduce tumor cell proliferation in colorectal cancer
Date:4/11/2013

sed therapies are the standard of care in treating ovarian cancer, however 60 percent of patients relapse requiring additional treatment. During cancer development, certain proteins that might otherwise block tumor growth are inappropriately shuttled out of the cell's nucleus, and rendered unable to attack a tumor's mutated genome. Researchers led by John A. Martignetti, MD, PhD, Associate Professor of Genetics and Genomic Sciences and Oncological Sciences at Mount Sinai, in collaboration with investigators at Karyopharm Therapeutics, inhibited a nuclear shuttle protein called exportin 1 (XPO1, also called CRM1) using a novel class of drugs called a selective inhibitor of nuclear export (SINE) that can be taken by mouth.

Ying Chen, PhD, a post-doctoral student in Dr. Martignetti's laboratory, injected tumor cells removed from ovarian cancer patients treated at Mount Sinai into mice, and then treated them with a SINE XPO1 inhibitor, KPT-330. All mice treated with KPT-330 had no visible evidence of tumor and survived six times longer than control mice.

Similarly, in another mouse model of chemotherapy-resistant ovarian cancer, KPT-330 significantly reduced the tumor burden and improved overall survival when compared against the current gold-standard platinum treatment. Moreover, mice treated with a combination of KPT-330 and platinum survived even longer. Human trials of KPT-330 are currently ongoing, and will include patients with ovarian cancer later this year.

In part, these experiments arose from a unique scientific resource established by Dr. Martignetti and Dr. Peter Dottino, MD, Associate Clinical Professor, Obstetrics, Gynecology and Reproductive Science. The Ovarian Cancer Translational Research Program preserves cancerous and normal tissues removed in the operating room from all consenting patients for genetic, genomic and therapeutic discoveries. Studies presented at AACR used patient-derived tumor tissues to create mouse tumor a
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Contact: Mount Sinai Press Office
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Source:Eurekalert

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