Muscle and joint pain improved significantly for both the 10 and 20 mg doses of S-equol compared with the soy isoflavones (p=0.003 and p=0.005, respectively), based on scores from the Greene Climacteric Scale (GCS), which measures 21 symptoms using 0 to 3 scale, where 0 was 'not at all,' 1 was 'a little,' 2 was 'quite a bit' and 3 was 'extremely,' to produce scores.
"These U.S. data expand on the previous studies in Japanese women and further document that a minimum daily 10 mg dose of S-equol would likely help women by both reducing the frequency of their hot flashes as well as decreasing their muscle and joint pain associated with menopause," said Jenks.
Further, for women who had more than eight hot flashes daily at the study start, both 20 and 40 mg S-equol were significantly better than the soy isoflavones in reducing hot flash frequency (p=0.045 and p=0.001, respectively), while the 10 mg S-equol dose had a strong positive trend (p=0.063), according to a sub-group analysis. This finding suggests that the S-equol supplement might be more useful for the women who have a higher frequency of hot flashes, Jenks said.
Also, more women in the 10, 20 and 40 mg S-equol groups achieved a reduction of 50 percent or more in their hot flash frequency by the study end than in the soy isoflavone group: respectively, 25.0, 27.3, 42.9 (P=0.056) and 16.0 percent.
No significant differences occurred between any of the S-equol groups and
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