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Soy-based S-equol supplement reduces hot flash frequency, muscle & joint pain in US women
Date:4/24/2012

Northridge, Calif. (April 24, 2012) A dose of 10 milligrams (mg) daily of S-equol delivered via a newly developed fermented soy germ-based nutritional supplement is as effective as a standard dose of soy isoflavones at reducing hot flash frequency significantly and is even more effective for relieving muscle and joint pain, according to a peer-reviewed study in US postmenopausal women published in the June Journal of Women's Health, available now as a Fast Track article online ahead of print.

"This study provides evidence that daily doses of the supplement S-equol, a metabolite of the soy isoflavone daidzein, reduced hot flash frequency and relieved muscle and joint pain in U.S. postmenopausal women. These findings confirm earlier studies in Japanese women documenting S-equol's ability to relieve menopausal symptoms," said Belinda H. Jenks, Ph.D., coauthor of the study and director of Scientific Affairs & Nutrition Education at Pharmavite LLC. Development and ongoing research of a supplement containing S-equol is conducted by the Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd. Pharmavite LLC, the makers of Nature Made vitamins and minerals, is a subsidiary of Otsuka, which supported the study.

S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in U.S. Women

Daily doses of the supplement containing 10, 20 or 40 mg of S-equol each reduced the frequency of moderate to severe hot flashes similarly to a 50 mg dose of a soy isoflavone supplement in a double-blinded randomized study involving 102 US postmenopausal women aged 45 to 65 who experienced more than 35 hot flashes weekly when they enrolled. The investigators used a standardized soy isoflavone supplement for comparison in the study because of the scientific consensus that extracts or concentrated soy isoflavones support relief of hot flashes in menopausal women, based on placebo-controlled studies.

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Contact: Stephen McCauley
smccauley@porternovelli.com
202-973-3615
Porter Novelli
Source:Eurekalert

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