Navigation Links
Southern Research Institute's Neurodegenerative Disease Drug Discovery Program Receives National Institute of Mental Health Funding
Date:10/1/2007

Team will develop "probes" to aid in the search for new Alzheimer's drugs

BIRMINGHAM, Ala., Oct. 1 /PRNewswire-USNewswire/ -- Southern Research Institute --- a not-for-profit organization that conducts basic and applied research in the areas of preclinical drug discovery and drug development -- today announced it has received funding from the National Institute of Mental Health (NIMH) to identify small molecules that activate Nuclear Factor-kB (NF-kB)--a transcription factor which could lead to the development of novel treatments of Alzheimer's disease and other neurodegenerative disorders.

Under the direction of Maurizio Grimaldi, M.D., Ph.D., Leader of the Neuropharmacology Laboratory, Department of Biochemistry, Drug Discovery Division at Southern Research, scientists will execute a drug discovery program utilizing a novel approach based on an original assay developed at Southern Research and high-throughput screening (HTS) technologies. There are several indications that the NF-kB signaling system plays a role in neuronal resilience and in the changes induced by cellular learning such as long term potentiation and depression. Several reports have shown that knocking out NF-kB activity in the brain causes sensitization to toxic stimuli, such as beta-amyloid, excitatory amino acids, and trauma. In addition, activation of NF-kB is a known anti-apoptosis mechanism.

"The global population is aging and the percentage of adults suffering from neurodegenerative diseases is increasing at alarming pace. There is an urgent need for effective therapeutics and methods to protect the brain. There is utility in investigating the possibility that NF-kB up regulation could be of value in mitigating both neurodegenerative phenomenon and learning and memory failure, a unique possibility, to attack the main clinical manifestations of Alzheimer's disease," said Dr. Grimaldi . "Southern Research's drug discovery program is a step towards identifying novel techniques, tools and, eventually, safe and effective treatment agents for these difficult-to-treat and debilitating neurodegenerative diseases."

Funding will be provided by National Institute of Mental Health. The National Institute of Neurological Disorders and Stroke donated the 108,000 compound collection which was selected by Southern Research medicinal chemists for the Institute high throughput screening program in neurodegenerative disorders. This project is also part of the NIH's Molecular Libraries Roadmap Initiative - an effort to broaden access to high throughput robotic assay technologies and facilitate the creation of a public database of small molecules and their biological effects. Southern Research participates in the Roadmap Initiative as a member of the Molecular Libraries Screening Centers Network (MLSCN). NIH's funding of MLSCN supports a research network that uses robotic HTS methods to identify small molecule probes as tools for drug discovery, and has helped enable Southern Research to incorporate the most advanced HTS and imaging technologies into its laboratories that are integral to drug discovery.

About Southern Research

Southern Research Institute is an independent 501-(c)-3, not-for-profit center for scientific research. Founded in 1941, Southern Research is known for innovative leadership in major scientific discoveries in drug discovery and development, aerospace and materials engineering, and environment and energy research. Public and private sector clients include the National Institutes of Health, U.S. Departments of Justice, Defense, Energy, Environmental Protection Agency and NASA, as well as major private companies in pharmaceutical, biotechnology, energy, manufacturing and more. For more information visit http://www.southernresearch.org.

CONTACT: Rhonda Jung of Southern Research Institute, +1-205-581-2317, Jung@southernresearch.org and Risa Burgess for Southern Research Institute, +1-205-581-2317, Southern@schwartz-pr.com


'/>"/>
SOURCE Southern Research Institute
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Bird Flu in Southern Russia
2. Southern States Health Ministers To Discuss Ways To Stop Chikungunya
3. Bird flu in Nigeria spreads its wings to southern states
4. Fresh Bird Flu Cases Spotted In Southern Russia
5. Food Shortage Hits Southern Africa Hard
6. Red Cross and Red Crescent Go the Extra Mile to Fight HIV/AIDS in Southern Africa
7. Bird flu Alert in Kenya after Outbreak in Southern Sudan
8. Massive expansion of Anti-AIDS programme in Southern Africa
9. Southern states join hands to protect biodiversity
10. Eighty Children Die Of Aids Due To Tainted Blood, Dirty Needles In Southern Kazakhstan
11. Southern California Wildfires Pose Health Risks to Children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... WA (PRWEB) , ... May 05, 2016 , ... ... user experience, adapted to people’s every day living patterns, Amerec, a Seattle-based steam ... computer and smart phone app. , The user interface of the app, developed ...
(Date:5/5/2016)... ... 05, 2016 , ... Talent Tech Labs (TTL) is pleased to ... National Nurses Week (May 6-12). Currently, HireNurses is a job listing and ... the Talent Tech Lab Virtual Incubation program, they will dramatically expand the functionality and ...
(Date:5/5/2016)... ... May 05, 2016 , ... Chronic stress can have a silent, ... can weaken the immune system and increase inflammation, both of which raise the risk ... adult congenital heart disease program at Harvard-affiliated Massachusetts General Hospital. Chronic stress also can ...
(Date:5/5/2016)... ... 2016 , ... T.E.N., a technology and information security executive ... the 2016 ISE® Central Executive Forum and Awards Gala at the Sheraton Downtown ... of HMS, was selected as the Information Security Executive® of the Year Award ...
(Date:5/5/2016)... ... May 05, 2016 , ... If you don’t mind a bit of prickly ... may want to consider a treatment that some have called the next great tool ... , Microneedling, also known as skin needling, is a procedure using a device covered ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... CITY, Mo. , May 3, 2016 /PRNewswire/ ... Kansas Medical Center,s Institute for Advancing Medical Innovation ... and commercialize new drugs, diagnostics and medical devices. ... provides BioNovus Innovations with rights to license, develop ... "This partnership represents ...
(Date:5/3/2016)... LAKE OSWEGO, Ore. , May 3, 2016 ... and endovascular medical technology, today announced Food and ... a cardiac resynchronization defibrillator that provides heart failure ... (MRI) scans. Iperia devices also have remote monitoring ... (CLS) that adapts the heart rate in response ...
(Date:5/3/2016)... , May 3, 2016 ... Market Size, Share, Development, Growth and Demand Forecast to ... by Field Strength (High Field, Very High Field, Low ... (Brain, Head and Neck, Spine, Musculoskeletal, Vascular, Breast, Pelvic ... global magnetic resonance imaging (MRI) market was valued at ...
Breaking Medicine Technology: