Navigation Links
Sour comes after a lemon has gone
Date:6/6/2008

The research group led by Professor Makoto Tominaga and Research Assistant Professor Hitoshi Inada (National Institute for Physiological Sciences, Okazaki, Japan) found that a sour taste receptor, PKD1L3-PKD2L1 channel complex, could be activated by acid stimulus but opened gate only after the removal of acid stimulus. They call this new type of response as "off-response" of sour taste receptor. They reports their finding in an international journal, EMBO reports, on June 6, 2008.

They investigated the PKD1L3-PKD2L1 channel activity stimulated by acid stimulus with calcium imaging method and electrophysiology. The cultured cells expressing PKD1L3-PKD2L1 channels showed a significant increase in intracellular Ca2+ not during the acid stimulation but only after the acid stimulus was washed out. The off-response property was also confirmed by whole cell patch-clamp configuration.

Prof Tominaga and Dr. Inada said "The PKD1L3-PKD2L1 channels exist on the taste bud in the side and the inner part of tongue, where the salivary glands are close. Acidic things such as spoiled foods and harmful solutions are supposed to be dangerous to human body so that they should be quickly removed by saliva. The off-response of PKD1L3-PKD2L1 channels, we found here, helps human to keep sour taste sensation even after acid stimulus has been washed out."


'/>"/>

Contact: Makoto Tominaga
tominaga@nips.ac.jp
81-564-595-286
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related medicine news :

1. MRI finds breast cancer before it becomes dangerous
2. Comparison of obstetric outcomes between on-call and patients own obstetricians
3. Continued Statin Use Boosts Post-Stroke Outcomes
4. Video: Nutrition Comes to NASCAR
5. MinuteClinic Becomes Participating Provider with Assurant Health
6. QI projects may -- or may not -- improve patient safety and outcomes
7. Hospitals Could Improve Outcomes for Patients and Save Millions According to Hill-Rom 10th Annual Pressure Ulcer Survey
8. Neusoft Becomes First Global Growth Company Partner of World Economic Forum
9. Michael Moores SiCKO Becomes the Third Highest Grossing Documentary of All Time Surpassing An Inconvenient Truth
10. Womens World Banking Welcomes New Network Member From Tunisia
11. Bypass Off-Pump Boosts Womens Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... 2017 , ... Wells Pharmacy Network, a proud A4M Platinum ... World Congress, in Hollywood Florida April 6-8, 2017. , Ben David, CEO of ... in the training of physicians, scientists, and members of the public on anti-aging ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... in Carnegie, OK, from Dr. Jamie Cameron, with or without a referral. ... to traditional orthodontic treatment. Depending on each patient’s case, treatment with the FASTBRACES ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... documenting and diagramming network and data center assets and audio-video devices has recently ... request new equipment shapes for free and download shapes and stencils from ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... many scientific laboratories. The assembly protocols involve many repetitive steps and often scientists ... automation, which enables the high-throughput needed, and results in a lower error rate ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... Gastrointestinal Oncology™ (SOGO™), a specialized continuing medical education conference for clinicians who manage ... Intercontinental Time Square, New York. , The program will be led by ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Research and Markets has announced the ... 2025" report to their offering. ... The global orthopedic navigation ... 2025. Increasing geriatric population prone to orthopedic diseases is a ... over the forecast period. Osteoarthritis and osteoporosis are most common ...
(Date:3/29/2017)... , March 29, 2017  Experts in the ... monitoring devices like  Soberlink Systems  as a model ... paper, published in early 2017, concluded that remote ... in managing patient recovery." The findings ... of Addiction Medicine, detail a range of variables ...
(Date:3/29/2017)... , March 29, 2017  Glenmark Pharmaceuticals, a ... GSP 301, an investigational fixed-dose combination of mometasone ... administered twice-daily as a nasal spray being studied ... results are from a recently completed Phase 3 ... 301 combination therapy versus mometasone, olopatadine or placebo. ...
Breaking Medicine Technology: