Navigation Links
Sour comes after a lemon has gone
Date:6/6/2008

The research group led by Professor Makoto Tominaga and Research Assistant Professor Hitoshi Inada (National Institute for Physiological Sciences, Okazaki, Japan) found that a sour taste receptor, PKD1L3-PKD2L1 channel complex, could be activated by acid stimulus but opened gate only after the removal of acid stimulus. They call this new type of response as "off-response" of sour taste receptor. They reports their finding in an international journal, EMBO reports, on June 6, 2008.

They investigated the PKD1L3-PKD2L1 channel activity stimulated by acid stimulus with calcium imaging method and electrophysiology. The cultured cells expressing PKD1L3-PKD2L1 channels showed a significant increase in intracellular Ca2+ not during the acid stimulation but only after the acid stimulus was washed out. The off-response property was also confirmed by whole cell patch-clamp configuration.

Prof Tominaga and Dr. Inada said "The PKD1L3-PKD2L1 channels exist on the taste bud in the side and the inner part of tongue, where the salivary glands are close. Acidic things such as spoiled foods and harmful solutions are supposed to be dangerous to human body so that they should be quickly removed by saliva. The off-response of PKD1L3-PKD2L1 channels, we found here, helps human to keep sour taste sensation even after acid stimulus has been washed out."


'/>"/>

Contact: Makoto Tominaga
tominaga@nips.ac.jp
81-564-595-286
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related medicine news :

1. MRI finds breast cancer before it becomes dangerous
2. Comparison of obstetric outcomes between on-call and patients own obstetricians
3. Continued Statin Use Boosts Post-Stroke Outcomes
4. Video: Nutrition Comes to NASCAR
5. MinuteClinic Becomes Participating Provider with Assurant Health
6. QI projects may -- or may not -- improve patient safety and outcomes
7. Hospitals Could Improve Outcomes for Patients and Save Millions According to Hill-Rom 10th Annual Pressure Ulcer Survey
8. Neusoft Becomes First Global Growth Company Partner of World Economic Forum
9. Michael Moores SiCKO Becomes the Third Highest Grossing Documentary of All Time Surpassing An Inconvenient Truth
10. Womens World Banking Welcomes New Network Member From Tunisia
11. Bypass Off-Pump Boosts Womens Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... (PRWEB) August 30, 2014 Ticket Down ... Chile exhibition match next Saturday at Levi's Stadium. ... diehard soccer fans in the United States due to the fact ... just about every major city. Many of these games were ... Brazil this past summer. , Levi’s Stadium is a brand new ...
(Date:8/30/2014)... Patients suffering from vitiligo can now discover ... review published by Daily Gossip. , Vitiligo is ... is no wonder that numerous sufferers search for an ... is one of the most appreciated such methods at ... stop the spread of this disorder immediately, while completely ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 The Plastic ... in New Jersey and even in the U.S. to ... takes inches off of patients’ waists with deep-tissue heating. ... in small sections, Vanquish is more inclusive to target ... Patients lay comfortably under panels about one inch away ...
(Date:8/30/2014)... Hicksville, NY (PRWEB) August 30, 2014 ... Organizations throughout the planet has been one of ... in order to create a positive impact around ... aesthetics and staffed with top trained executives and ... millions of people worldwide. Vital statistics demonstrate ...
(Date:8/30/2014)... VA (PRWEB) August 30, 2014 Seniors Guide, ... articles recently that focus on Alzheimer’s Disease, Dementia, and ... revealed to the public of being diagnosed with the Alzheimer’s, ... latest movie, “I’ll Be Me”. The movie, out on ... while focusing on his diagnosis of the disease – which ...
Breaking Medicine News(10 mins):Health News:Mexico vs. Chile Tickets at Levi's Stadium in Santa Clara, CA: TicketDown.com Offers Promo Code for Mexico vs. Chile Exhibition Game on September 6th 2Health News:Natural Vitiligo Treatment Review Exposes Fast Method for Skin Repigmentation 2Health News:NJ Top Docs Presents, The Plastic Surgery Group 2Health News:Cradle of Aviation Museum Opens Its Doors to Long Island Scientologists 2Health News:Alzheimer’s Disease and Dementia Focus on Retirement Website SeniorsGuideOnline.com 2
... assured that the Federal Government would provide $47,000 as ... ,This money would help the community health care ... this difficult transitional period. Health services play a major ... problems backing that up with financial support. Due to ...
... extremely optimistic trends in the reaction to same-sex ... to such marriages across the country. Gay rights ... opposition to same-sex marriages, while also expressing that ... highest court order prohibiting inter-state homosexual marriages. ...
... the firing of editor-in –chief, John Hoey, the Canadian ... controversies//. The February firing of Dr. Hoey and senior ... international controversy regarding the editorial independence of medical journals. ... ran several articles and editorials that sparked anger among ...
... and lifestyle alone will suffice to prevent about two-thirds of ... disposition play a role in skin cancer. While anyone can ... light-colored skin that freckle easily, researchers said. ... members who also have had the disease, but everyone should ...
... According to the joint study conducted by India and Canada which ... research institute reported// a decrease in the HIV prevalence. The ... HIV in the states of Tamil Nadu, Maharashtra, Karnataka and Andhra ... period. This tread is mainly seen in the four south Indian ...
... planning to record the barks and growls of hundreds of dogs ... Taylor, 23, of Brighton in southern England, is looking for about ... part in the study, it was reported Thursday. ,"We ... and growl including banging on doors and windows, playing with them ...
Cached Medicine News:Health News:Future of Canadian Medical Association Journal Threatened 2
(Date:8/29/2014)... 29, 2014 Research and Markets  has announced ... Insight 2014" report to their offering. ... one of the largest segments of pharmaceuticals industry. The numbers ... the available therapies were unable to meet the market requirements. ... for CNS disorder, especially over the past two decades. The ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... Research and Development Trend Forecast of Pharmaceutical Equipment ... analyzes China,s pharmaceutical equipment industry ... demand, competition landscape, and business performance of domestic major ...
(Date:8/29/2014)... , August 29, 2014 ... Market by Product & Services (Equipment, Reagent, Primer, ... Application (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, ... MarketsandMarkets, the global Oligonucleotide Synthesis Market is expected ... Million in 2014, growing at a CAGR of ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4
... 15, 2011 When you,re ... and food safety is crucial for brand confidence and ... specialises in pork pies and other popular savouries and ... the latest innovation from Digitron Instrumentation Ltd. ...
... Nektar Therapeutics, (Nasdaq: NKTR ) President and Chief ... the upcoming UBS 2011 Global Life Sciences Conference in New ... 2011 at 10:00 a.m. Eastern time. The presentation ... on the Investor Relations, Events Calendar section of the Nektar ...
Cached Medicine Technology:Temperature Monitoring Device From Digitron Helps Pork Farms Take a Big Bite of the Food Market 2Temperature Monitoring Device From Digitron Helps Pork Farms Take a Big Bite of the Food Market 3Nektar Therapeutics' President and CEO, Howard W. Robin, to Present at the UBS 2011 Global Life Sciences Conference in New York City 2
Lightly Curved-Blunt Tips Rounded Blades; 1mm Eye in Blades; 27mm from mid screw to tip. Matte finish; Stainless Steel, overall length 120mm...
... SURPASS Perfusion Catheter is indicated ... stenotic portion of a coronary ... for the purpose of improving ... Catheters are also designed to ...
16mm from Mid-screw to Tips, blunt tips; overall length 110mm; Stainless Steel...
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right; ) overall length 120mm; Stainless ...
Medicine Products: