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Sound medicine at Acoustics Meeting
Date:11/13/2007

y due to mechanical tissue disruptions that may release clotting factors.

Zderic will make two presentations on this research in New Orleans. The first will look at studies by Vaezy and colleagues, who tested high-intensity focused ultrasound to control bleeding in a variety of deep-seated tissues, including the liver, spleen, kidneys, and blood vessels. They tested a range of ultrasound energies and found they can achieve faster coagulation if the ultrasound produces bubbles at the focus. They conclude that therapeutic ultrasound would be a safe and useful procedure for hemorrhage control because the acoustical waves can be focused deep within the body where the bleeding occurs. It also can be used with conventional ultrasound to guide the area of focus and precisely target the bleeding.

They are also looking to use therapeutic ultrasound to aid in delivering drugs. In this sort of application, ultrasound has to be much less energetic so that the heat does not damage the tissues. Rather than heating the tissue, the idea is to produce a highly localized area of microbubbles that essentially produce temporary holes in the membranes of cells in that area and allow drugs that are present there to diffuse more easily. Zderic and her colleagues are also currently conducting preclinical studies, producing these tiny bubbles in the cornea to deliver antibiotics and anti-inflammatory compounds to treat serious infections of the eye. The same principle could be used to enhance the absorption of drugs through the skin.

The talk Acoustic hemostasis: underlying mechanisms (2aBB3) will be at 9:15 a.m. on Wednesday, Nov 28.

The talk Therapeutic potential of stable cavitation: from enhanced drug delivery to faster hemorrhage control (4pBB3) will be at 2:10 p.m. on Friday, Nov 30.

2) BETTER DETECTION OF THYROID CANCER

Ultrasound is currently the most sensitive tool for detecting thyroid nodules and the most cost-effective im
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Contact: Jason Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

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