Navigation Links
Sorafenib significantly improves the length of time before breast cancer worsens
Date:9/23/2009

Berlin, Germany: One of the first of a series of trials to investigate the use of sorafenib a targeted anti-cancer drug for the treatment of advanced breast cancer has found that if it is combined with the chemotherapy drug, capecitabine, it makes a significant difference to the time women live without their disease worsening.

Principal investigator of the study, Professor Jos Baselga told Europe's largest cancer congress, ECCO 15 ESMO 34 [1], in Berlin today (Wednesday 23 September): "This is the first, large, randomised study that demonstrates significant clinical activity of sorafenib in breast cancer when given in combination with chemotherapy. Our results showed that patients who received sorafenib plus capecitabine had a 74% percent improvement in the time they lived without their disease worsening compared to those who received the chemotherapy alone. This is a very positive study and the magnitude of the benefit is such that it suggests that this agent will be an important addition to our therapeutic armoury in breast cancer."

Sorafenib (Nexavar) is a potent multi-kinase inhibitor, which works by interfering with the growth of cancer cells and slowing the growth of new blood vessels within the tumour. Until now, it has only been used in the treatment of kidney and liver cancer.

Prof Baselga, who is head of the oncology department at Vall d'Hebron University Hospital (Barcelona, Spain), president of ESMO (European Society for Medical Oncology) and a member of the ECCO (European CanCer Organisation) executive committee, and his colleagues in Spain, France and Brazil enrolled 229 patients with locally advanced or metastatic breast cancer in the double-blind, randomised phase II clinical trial between June 2007 and December 2008. They randomised the patients to receive capecitabine (1000 mg/m2 pill taken twice daily for 14 of every 21 days) and a placebo (114 women), or capecitabine and sorafenib (400 mg pill taken twice daily
'/>"/>

Contact: Emma Mason
wordmason@mac.com
44-771-129-6986
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Drug Sorafenib Improves Kidney Cancer Outcomes
2. Sorafenib Shows Promise for Heart-Lung Disease
3. Analysis shows combining sorafenib with carboplatin/paclitaxel adds no benefit in lung cancer
4. Sorafenib Slows Growth of Some Leukemias
5. Women with atrial fibrillation are at significantly higher risk of stroke and death compared to men
6. Phoenix Children's Hospital Significantly Reduces Costs with Orion Health™ Technology
7. Radiologists find a technique to significantly reduce patient radiation dose during CT angiography
8. New Survey of People With Diabetic Nerve Pain Shows the Condition Significantly Impacts Daily Activities Such as Exercise and Sleep Yet Often Goes Untreated
9. African Americans at Significantly Higher Risk of DVT or Blood Clots
10. Significantly Higher Percentage of Hetastarch Recipients Underwent a Surgical Procedure Than Those Receiving Albumin/Plasma Protein Fraction
11. New Data Show ChloraPrep(R) Significantly More Effective Than DuraPrep(TM) and Povidone-Iodine in Eliminating Bacteria From Skin Prior to Shoulder Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... 30, 2015 AVT, the world leader ... is joining forces with leading proofing solutions provider Global ... worldwide printing market. , Under the agreement, ... engine for its offline inspection solutions, which are customized ... and its varying production workflow setups and printing applications. ...
(Date:5/30/2015)... Metamora, Michigan (PRWEB) May 30, 2015 ... procedure to lighten or stop periods, without the ... This procedure can reduce or stop menstrual bleeding and ... the uterus (the part that causes the bleeding), with ... million women suffer from heavy menstrual bleeding. Many ...
(Date:5/30/2015)... 2015 Boston Scientific Corp. has ... and compensatory damages to a transvaginal mesh lawsuit ... following implantation of the company’s Pinnacle and Advantage ... May 28th in Delaware Superior Court, the plaintiff ... the jury found that the implants were defectively ...
(Date:5/30/2015)... Minnesota (PRWEB) May 30, 2015 ... acquired the Disability Income Associate (DIA) designation to ... The DIA designation is designed for insurance advisors, ... to further their knowledge and expertise associated with ... Earning the DIA designation is only the latest ...
(Date:5/30/2015)... (PRWEB) May 30, 2015 Wixom, Michigan: Proof. Pest ... services, has added a new twist to its robust line ... organic services are used for general pest management. ... Allan Draper, proof.’s Wixom Branch Manager. “The average person cringes ... pride in dealing with problems that most people don’t even ...
Breaking Medicine News(10 mins):Health News:AVT and Global Vision Collaborate to Offer Cutting-edge Offline Inspection Solutions for Printing Industry 2Health News:AVT and Global Vision Collaborate to Offer Cutting-edge Offline Inspection Solutions for Printing Industry 3Health News:Women's Excellence Now Provides NovaSure Treatment 2Health News:Boston Scientific Transvaginal Mesh Lawsuit Trial Ends With $100 Million Verdict 2Health News:Boston Scientific Transvaginal Mesh Lawsuit Trial Ends With $100 Million Verdict 3Health News:Boston Scientific Transvaginal Mesh Lawsuit Trial Ends With $100 Million Verdict 4Health News:Secura Consultants Expands Disability Insurance Expertise 2Health News:Proof. Pest Control-Now Offering 100% Organic Pest Control in Southeast Michigan 2
... male babies born in the U.S. is dropping. And environmental factors ... pattern//, says a new study. ,Researchers have found that ... three decades. The decline is equivalent to 135,000 fewer white males ... is confined to whites only. ,In Japan too ...
... just 798 girls per 1,000 males in the 0-6 age ... Art of Living Foundation//, to tackle the practice of female ... Sanjivni Yatra - by the Foundation in collaboration with the ... Thursday concluded a statewide campaign to make people aware of ...
... struggle with the heartache of infertility. Now there is the ... mutation in a gene that causes male infertility in mice. ... that leads specifically to infertility in a mammal has been ... mutations in the DNA of infertile men. ,Up ...
... international found that doctors do a good job of ... even before laboratory tests confirm// the diagnosis. The study ... ,“There has always been a concern that patients may ... attack symptoms before laboratory tests are able to confirm ...
... enrolling schools in the fight against obesity has started delivering ... ,A pilot program was started in one of the ... encourage healthy eating habits among school children. ... participating in this three year old program called ‘Healthy School.’ ...
... the ‘gateway to navigate the NHS services’, UK ‘s ... give patients// the choice to select their hospital and doctor, as ... ,Says Hewitt: “We are determined to put patients at the heart ... information about health services is a crucial part of that. “Patients ...
Cached Medicine News:Health News:Male Child Birth Dropping in US and Japan 2Health News:Discovery in Male Mice Gives Hope in Providing Clues to Find Infertility in Men 2Health News:Discovery in Male Mice Gives Hope in Providing Clues to Find Infertility in Men 3Health News:Doctors Treat Early Heart Attacks Before Labs Could Confirmation It 2Health News:Doctors Treat Early Heart Attacks Before Labs Could Confirmation It 3Health News:Campaign Against Obesity Taken to Schools in US 2Health News:NHS Online- Promise Of ‘Choices’ To Patien 2
(Date:5/30/2015)... SPARTANBURG , Carolina del ... - Nueva colaboración para ampliar drásticamente el ... cáncer en los Estados Unidos   ... proporcionarán a los pacientes con cáncer apoyo de ... Research Network y Molecular Health han anunciado una ...
(Date:5/30/2015)... May 30, 2015  Eisai Inc. announced today the results ... eribulin met the study,s primary endpoint evaluating overall survival in ... two types of advanced soft tissue sarcoma. These data will ... the American Society of Clinical Oncology (ASCO) in ... on Saturday, May 30, and also in an oral session ...
(Date:5/30/2015)... 30, 2015 Caris Life Sciences®, a ... of precision medicine, today announced the presentation of ... of Caris Molecular Intelligence®, the company,s panomic comprehensive ... that share histological features. In separate presentations at ... Clinical Oncology (ASCO) in Chicago, Ill. ...
Breaking Medicine Technology:Nueva colaboración para ampliar el acceso al ensayo clínico terapéutico para pacientes con cáncer en EEUU 2Nueva colaboración para ampliar el acceso al ensayo clínico terapéutico para pacientes con cáncer en EEUU 3Nueva colaboración para ampliar el acceso al ensayo clínico terapéutico para pacientes con cáncer en EEUU 4Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 2Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 3Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 4Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 5Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 6Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 2Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 3Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 4Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 5Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 6
... 25, 2011 Omthera Pharmaceuticals, Inc., a privately-held emerging ... has joined the Company as Vice President of Quality. ... Operating Officer, Drs. Ben Machielse, Mr. Maines will be ...   Mr. Maines brings to the Company ...
... 2011 GlaxoSmithKline, one of the world,s leading ... 10 winners of its GlaxoSmithKline IMPACT Awards. In ... organizations will receive $400,000 in grant funding for ... their communities. Three of the North ...
Cached Medicine Technology:Timothy J. Maines Joins Omthera Pharmaceuticals as Vice President of Quality 2GlaxoSmithKline to Grant $400,000 to Healthcare Nonprofits at Annual IMPACT Awards 2GlaxoSmithKline to Grant $400,000 to Healthcare Nonprofits at Annual IMPACT Awards 3
Nursing2006 Drug Handbook Entries include Alerts, dosage adjustments for specific populations, I.V. administration, off-label indications, adverse reactions, and more....
... Nurse's Pocket Drug Guide 2005 includes over ... data relating to their selection and administration. ... each drug includes key data featuring common ... nursing implications and patient education information. A ...
The mission of AHFS DI Essentials (American Hospital Formulary Service) is to provide an evidence-based foundation for safe and effective drug therapy....
Ident-A-Drug gives you quick accurate identification of oral tablets and capsules used in North America....
Medicine Products: