Navigation Links
Sorafenib Slows Growth of Some Leukemias
Date:2/1/2008

Drug shows potential for patients with specific gene mutations, researchers find

FRIDAY, Feb. 1 (HealthDay News) -- The drug sorafenib shows promise in the treatment of people with acute myeloid leukemia who have specific gene mutations, say U.S. researchers.

Previous research has shown that sorafenib -- currently used to treat kidney and liver cancer -- is effective against acute myeloid leukemia cells that have internal tandem duplication (ITD) mutations of the Fms-like tyrosine kinase 3 (FLT3) gene, according to background information in the study.

Researchers at the University of Texas M.D. Anderson Cancer Center in Houston looked at sorafenib's effect on leukemia cells that express either the common or mutant copies of FLT3. They also gave the drug to mice with leukemia cells with known FLT3 mutations and to leukemia patients with and without the FLT3 mutation.

Sorafenib slowed growth and induced cell death in the FLT3 mutant leukemia cells and increased survival of the mice with FLT3 mutant leukemia. The drug also reduced the percentage of leukemia cells in the blood and marrow of leukemia patients with the FLT3 mutation but not in leukemia patients without the mutation.

"Our findings imply that sorafenib is a potent anti-leukemic agent in patients with FLT3-ITD mutant [acute myeloid leukemia], a form of [the disease] that responds poorly to traditional chemotherapy," the study authors concluded.

The findings were published in the Jan. 29 issue of the Journal of the National Cancer Institute.

More information

The American Cancer Society has more about acute myeloid leukemia.



-- Robert Preidt



SOURCE:Journal of the National Cancer Institute, news release, Jan. 29, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Health Insurance Premium Growth Slows for Fourth Straight Year
2. Philanthropic Giving for Health Care Slows in 2006 in both U.S. and Canada, According to Association for Healthcare Philanthropys Annual Report on Giving
3. Drug slows prostate tumor growth by keeping vitamin A active
4. Enrollment Growth Slows at U.S. Nursing Colleges and Universities in 2007 Despite Calls for More Registered Nurses
5. High pollution linked to poor lung function growth in children in Mexico City
6. Researchers develop long-lasting growth hormone
7. Expanding Prevalent Population Will Drive Dramatic Growth for the Asthma Drug Market in China
8. Plexus Systems Ranks in Top Third of the 2007 Inc. 5,000 with Three-Year Sales Growth of 226%
9. Neusoft Becomes First Global Growth Company Partner of World Economic Forum
10. AWT Management Announce Aggressive Growth and Acquisition Strategy
11. Cynosure to Present at the Maxim Group Growth Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sorafenib Slows Growth of Some Leukemias
(Date:5/24/2016)... , ... May 24, 2016 , ... Sterling Global Products ... a unique and patented refillable hanging wipe dispenser. The campaign kick-off video is located ... will end June 25, 2016. The goal is to raise $1,000 per day for ...
(Date:5/24/2016)... IL (PRWEB) , ... May 24, 2016 , ... To ... created a new research award to examine gender differences in lung cancer. Today, the ... Research Innovation Project: Lung Cancer in Women Award, funded by the American Lung Association’s ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... debuted a new corporate identity and website at its “Transforming Outcomes” User Conference ... other marketing enhancements reflect i2i’s ongoing success to set the market standard for ...
(Date:5/24/2016)... (PRWEB) , ... May 24, ... ... nationwide provider of communication enabled solutions and managed services today announced a ... for the enterprise contact center market. , Altura, one of Avaya’s largest ...
(Date:5/24/2016)... Falls Church, VA (PRWEB) , ... May 24, 2016 , ... ... June 14-15, 2016 · Raleigh, NC, http://www.fdanews.com/humanerrordrugdevice , Human error is known ... it is unlikely that human error will ever be totally eliminated, many human performance ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 Een app die artsen ... collectief patiënten kunnen behandelen, hun kennis kunnen delen en ... de nieuwe en revolutionaire MDLinking App, ontwikkeld door een ... dr. Hans Flu en oncologisch chirurg dr. Gijs ... is, wordt op dinsdag 24 mei officieel gepresenteerd op ...
(Date:5/23/2016)... 23, 2016 According to ... Development, Growth and Demand Forecast to 2022 - ... by Application (Drug Discovery and Development, Proteomics, Clinical ... Life Science and Biotechnology, Academic and Research Institute, ... the global mass spectrometry market was ...
(Date:5/23/2016)... , May 23, 2016 Gamida ... the treatment of cancer and orphan genetic diseases, announced ... to $4.4 million from the Israel Innovation Authority (formerly ... Ministry of Economy and Industry. The mission of the ... in various industries, including science and technology, while stimulating ...
Breaking Medicine Technology: