Navigation Links
Sonic Hedgehog variations linked to recurrence, survival and response to therapy of bladder cancer
Date:12/9/2009

HOUSTON - Genetic variations in the Sonic Hedgehog pathway increase the likelihood of recurrence, reduce survival time and limit response to therapy for people with non-muscle invasive bladder cancer, scientists from The University of Texas M. D. Anderson Cancer Center reported today at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference.

"These variations are strongly associated with response to standard immunotherapy that patients receive after tumor resection," said senior author Xifeng Wu, M.D. Ph.D., professor in M. D. Anderson's Department of Epidemiology. "Discovering the genetic aspects of bladder cancer risk is another step toward personalized cancer therapy. We are combining genetic and epidemiological information to build a model that predicts bladder cancer risk and helps guide treatment in the clinic."

Patients who had zero or one of five GLI3 variations associated with response to the Bacillus Calmette-Guerin (BCG) immunotherapy to prevent recurrence had a mean recurrence-free survival time of 114.7 months compared with 9.9 months for those with two-to-five variations.

The Sonic Hedgehog cell signaling pathway plays an important role in embryonic development and stem cell maintenance.

"Abnormal activation of this pathway has been implicated in development of various cancers and progression to metastasis, so we hypothesized that genetic variations might affect bladder cancer patients' clinical outcomes," said Meng Chen, Ph.D., the study's first author.

The team evaluated 494 non-muscle invasive bladder cancer patients for 151 single nucleotide polymorphisms - variations of a single DNA building block in a gene - in nine genes in the pathway.

Patients with non-muscle invasive disease comprise 70-80 percent of all bladder cancer cases. They have a high recurrence rate, at 70 percent, but only 10-15 percent have their disease progress to the invasive s
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Ultrasonic Cleaner from Tovatech Plays Key Role in World Health Organization's Guidelines for Infection Control
2. VisualSonics Appoints New President and CEO
3. Brooke Burke Debuts Limited Edition Couture Clarisonic on Ultimate Style Stage: The SGK Pink Dress Runway at New York Fashion Week
4. Misonix Expands Sales Organization for Direct Sales of the SonicOne(TM) Wound Management System and the SonaStar(R) Ultrasonic Surgical Aspirator in the United States
5. Keep Oral Health in Check This School Year With the New Philips Sonicare for Kids Power Toothbrush
6. Sonic Innovations Awarded Contract From U.S. Veterans Administration
7. Otix Global, Inc. to Become Parent Company of Sonic Innovations, Inc.
8. Clarisonic Pounds the Pavement Pink Offering Generous Donation at 2009 Entertainment Industry Foundation Revlon Run/Walk for Women
9. Misonix Announces the Sale of Its Ultrasonic Laboratory Business for $3.5 Million to iSonix LLC
10. Sonic Innovations Celebrates Companys First Receiver-In-Canal Hearing Aid
11. SonicWALL Delivers Flexible High-Performance Threat Management for ZirMed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sonic Hedgehog variations linked to recurrence, survival and response to therapy of bladder cancer
(Date:7/13/2014)... If Dr. Lawrence Power has his way, the innovative ... http://www.HealthYourself101.com will expand people’s understanding of the causes, consequences, ... out to provide a health education platform on this modern ... say it? – entertaining to dig into and learn from. ... remote learner – the solitary individual signing on from a ...
(Date:7/12/2014)... Recently, Fadhits.com, a well-known wedding dress manufacturer ... graduation dresses to its product line. In addition, ... clients. It wants to bring more benefits for its loyal ... at discounted prices, up to 72% off. , As a ... hard. Its online shop is a good place for ladies ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 The rise ... has urged for new advanced network architectures to suit ... the IT industry with increasing cloud storage technologies. The ... advent of more mobility devices. This has resulted in ... the main driving forces for the SDN market. , ...
(Date:7/12/2014)... 12, 2014 Demand Response Management Systems ... benefits in reducing the imbalance between energy supply and ... have been rolled out (due to increasing pressure on ... This helps in controlling residential appliances and thermostats for ... the North American region, and with government mandates and ...
(Date:7/12/2014)... If you make exercise fun, you,ll eat less after your ... were led on a 1.4-mile walk and were either told ... The participants were given lunch after the walk, and those ... percent more chocolate pudding for dessert than those who were ... 46 adults were given mid-afternoon snacks after their walk. Those ...
Breaking Medicine News(10 mins):Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:New Collection of Long Graduation Dresses Revealed by Fadhits.com 2Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 5Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 4Health News:Make Exercise Fun, Eat Less Afterwards 2
... 19 People who have experienced the,death of a ... family traditions will never be the same; the hope ... depression and loneliness. This,year,s economic downturn will add even ... financial circumstances. , ...
... issues around patient comfort gaining,momentum, hospitals and healthcare decision ... welfare. This is leading to a growing demand for,patient ... greater,number of patients and not just the aged and ... http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) , ...
... Sex, Less Pain, researchers examine a non-surgical therapy to treat ... ... (PRWEB) November 19, 2008 -- Endometriosis is a painful and debilitating ... quality of life. While the cause of endometriosis is unknown, some ...
... Firm Makes Informational Center Available to People Affected by Plastics Plant Fire ... ... law firm Williams Kherkher has set up an informational resource center ... plant in Deer Park. , ,At approximately 7:15 AM Tuesday morning, ...
... highlights need for complete, unbiased information on Medicare choices. ... ... 2008 - Medicare beneficiaries trying to sort through their healthcare ... them against overly aggressive marketing tactics by some insurance companies ...
... patients, the resulting acne scars which last long ... psychosocial distress. Now, a new study recently ... 2008 issue), the peer-reviewed professional journal of the ... that a novel laser device combining CO2 ablation ...
Cached Medicine News:Health News:Surviving the Holidays After a Loved One's Death: Economic Woes Add to Holiday Pressure for People Who Grieve 2Health News:Patient Temperature Management Systems Enjoying Wider Usage 2Health News:Patient Temperature Management Systems Enjoying Wider Usage 3Health News:Alternative Therapy for Adhesion and Endometriosis Pain Examined in New Book 'Miracle Moms, Better Sex, Less Pain' 2Health News:Alternative Therapy for Adhesion and Endometriosis Pain Examined in New Book 'Miracle Moms, Better Sex, Less Pain' 3Health News:Williams Kherkher Provides Resource Center after Deer Park Plant Fire 2Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 2Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 3Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 4Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 2Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 3Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 4
(Date:7/10/2014)...  The U.S. Department of Health and Human Services ... (UH) Case Medical Center Seidman Cancer Center totaling $4.7 ... improving care for patients with complex cancer. ... a unique model developed at UH to enhance care ... or demonstrated need for high health care utilization.  ...
(Date:7/10/2014)... July 10, 2014 Yesterday, former Congressman ... medical device manufacturing facility. Rep. Kennedy and ... monitors facilitate cutting-edge research in neurological disease and ... mental health advocate, Garen Staglin , created ... fostering fundamental changes that will radically accelerate the ...
(Date:7/10/2014)... 10, 2014  Decision Resources Group finds that ... (ID) specialists are willing to prescribe Durata,s Dalvance ... use as OPAT, approximately two-thirds of the respondents ... their hospital inpatients. However, our findings indicate that ... initiated on OPAT following hospital discharge, and most ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: