Navigation Links
Some women with abnormal breast lesions may avoid surgery
Date:7/29/2013

OAK BROOK, Ill. -- Surgery is not always necessary for women with a type of breast tissue abnormality associated with a higher risk of cancer, according to a new study published online in the journal Radiology. Researchers said that periodic imaging and clinical exam are effective in these patients when radiology and pathology findings are benign and concordant, or in agreement.

Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) are abnormal breast lesions that occasionally appear as incidental findings in breast biopsies. Women with ALH or LCIS have a four to 10 times higher risk of developing breast cancer, according to Michael A. Cohen, M.D., FACR, professor of radiology at the Emory University School of Medicine in Atlanta. As a result, it is often recommended that ALH and LCIS diagnosed on image-guided core biopsy be removed surgically.

"Because of the possibility of upgrade to cancer, the bulk of the published literature says that the prudent thing to do is excise ALH and LCIS," Dr. Cohen said.

But new research from Dr. Cohen, Kristen Atkins, M.D., and colleagues may alter that thinking.

Dr. Atkins is a pathologist and associate professor at the University of Virginia in Charlottesville, Va. At one time, Drs. Cohen and Atkins were colleagues there and had many discussions about balancing the risk of cancer in ALH and LCIS patients with the costs and potential complications of surgery.

"From a pathology perspective, ALH and LCIS are often very tiny lesions, so we wondered why they were getting excised," Dr. Atkins said. "These surgeries may involve general anesthesia and possible disfigurement."

The researchers studied 10 years of pathology and radiology data to look for a correlation between the number of ALH and LCIS cases that were upgraded to cancer after surgery or follow up and the concordance between the radiologist and pathologist.

The research yielded 50 cases from 49 women aged 40 to 73 years. Radiologist and pathologist findings were concordant in 43 of the 50 cases. None of the benign concordant cases were subsequently upgraded to cancer, strongly suggesting that observation in these patients would have been a viable alternative to surgery. Of the seven discordant cases, two were upgraded to ductal carcinoma in situ, or DCIS, an early-stage, noninvasive form of breast cancer.

Dr. Cohen repeated the study after moving to Emory and found the same results.

"When there's no discordance between the radiologist and pathologist after thorough radiology-pathology correlation, there's no upgrade from ALH or LCIS to cancer in our study," Dr. Cohen said. "These findings show that some women can avoid surgery, and that yearly mammograms along with MRI or ultrasound as second-line screening tools may suffice."

The researchers suggested that their findings will help physicians and patients make informed decisions about ALH and LCIS.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. RSNA: Some Women With Abnormal Breast Lesions May Avoid Surgery
2. New Additions In The Ravishing Collection Of Women’s Clothes By 4leafcity.com
3. Coronary artery disease continues to be neglected in women, despite it killing at least as many women as men
4. The Most Awaited for Sale at 4leafcity.com Now Opens with 80% off on Its Women’s Line
5. Pregnant Women Who Use Nasal Decongestants During the First Trimester May Increase Their Babies’ Risks of Birth Defects; Parker Waichman LLP Is Evaluating Legal Claims
6. Womens height linked to cancer risk
7. How To Break the Sugar Habit, from the July 2013 Harvard Women's Health Watch
8. An Exquisite Collection Of Women’s Dresses Now Available At Cheap Rates At 4leafcity.com
9. Carlos Cavallo's Forever Yours System Named #1 Women's Dating Guide By ConquerHisHeart.com
10. Women’s Choice Award® Honors Mount View Care Center As Most Recommended by Women
11. Best Eye Lash Extensions for Women Explored in New Research Published Online at eHealthMax.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... ... ... “Sound of My Song”: an intriguing and thought-provoking on love, life, and ... retired teacher with a passion for music and ancestral history. , Published by ... loss, living with depression, and finding love through the journey. There is powerful imagery ...
(Date:9/26/2017)... ... ... the life story of the author and the exciting times this adventurer has lived through. ... tour guide and the subject of the book. , “Quickly slapping a large smile ... played it off as a part of the adventure tour, an “added bonus” story they ...
(Date:9/26/2017)... ... September 26, 2017 , ... Time out for Daddy is a moving ... understanding that even grownups make mistakes. “Time Out for Daddy” is the creation of ... entire life and whose passion for children inspired her to write this book. , ...
(Date:9/25/2017)... Texas (PRWEB) , ... September 25, 2017 , ... ... VitalBand, the first and only fully programmable fall detection smart watch. VitalBand ... as many critical contacts as you want so help arrives quickly. Plus, ...
(Date:9/25/2017)... Reston, VA (PRWEB) , ... September 25, 2017 ... ... mobile application security, today announced its latest release of SentinelSecure™, version 3.0, will ... website Secure.Systems . This newest version of SentinelSecure™ comes with several new ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/23/2017)... 2017 Janssen Biotech, Inc. (Janssen) announced today ... the U.S. Food and Drug Administration (FDA) for the ... the treatment of moderately to severely active rheumatoid arthritis ... are needed to further evaluate the safety of sirukumab ... "We are ...
Breaking Medicine Technology: