Navigation Links
Some types of temporary neurological problems associated with increased risk for stroke, dementia
Date:12/25/2007

Patients who experience symptoms described as transient neurological attacks, such as temporary amnesia or confusion, may have a higher risk for stroke and dementia, according to a study in the December 26 issue of JAMA.

Transient neurological attacks (TNAs) are episodes involving temporary (less than 24 hours) neurological symptoms. These symptoms can be nonfocal (that can include nonlocalizing cerebral symptoms), focal (known as transient ischemic attacks [TIAs], similar to ischemic stroke, except for duration [commonly 2-15 minutes, maximum 24 hours]), or a mixture of both focal and nonfocal. Although it has been well-documented that patients with TIA are at high risk of major vascular disease, few studies have examined whether nonfocal TNAs are a serious health threat, according to background information in the article.

Michiel J. Bos, M.D., M.Sc., of Erasmus Medical Center, Rotterdam, the Netherlands, and colleagues studied the incidence and prognosis of focal, nonfocal and mixed TNAs. The study included 6,062 participants who were age 55 years or older and free from stroke, heart attack, and dementia when they entered the study (1990-1993), and were followed-up until January 2005.

During the study a TNA occurred in 548 participants; 282 of these were classified as focal, 228 as nonfocal, and 38 as mixed. In both men and women, the incidence rates for nonfocal TNAs were almost as frequent as focal TNAs, and for both types of events the incidence rates strongly increased with increasing age. Mixed TNAs were less frequent.

During follow-up, there were 619 cases of stroke, 848 cases of ischemic heart disease, 662 vascular deaths (also classified as having stroke [192] or ischemic heart disease [430]) and 609 cases of dementia. Compared with participants without TNA, participants with focal TNA had more than twice the risk of stroke and 2.6 times the risk of ischemic stroke; the risk of stroke within 90 days after focal TNA (TIA) was 3.5 percent. Patients with nonfocal TNA had a 56 percent higher risk of stroke and 59 percent higher risk of dementia, than participants without TNA.

Patients with mixed TNA were at increased risk of stroke, especially ischemic stroke; ischemic heart disease, especially heart attack; and vascular death and dementia, compared with participants without TNA.

Our findings challenge the strong but unfounded conviction that nonfocal TNAs are harmless. On the contrary, our findings suggest that nonfocal TNAs are not only a risk factor for stroke, but also for dementia, the authors write.

(JAMA. 2007;298(24):2877-2885. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


Editorial: Transient Neurological Attack - A Useful Concept?

In an accompanying editorial, S. Claiborne Johnston, M.D., Ph.D., of the University of California, San Francisco, writes that this study reports important new information.

this is the first large-scale study of TNAs, and the findings are intriguing for several reasons. Most patients with nonfocal TNAs are currently treated as though the condition were benign. For some etiologies, such as transient global amnesia, the evidence supports this, but for most of these events, there is no consistent evaluation, no guidelines for treatment, and no information on prognosis. This study argues that, whatever is causing these events, the prognosis justifies greater attention. More needs to be done to identify the TNA patients at greatest risk, to complete evaluations, to rule out important underlying disease, and to continue to study this heterogeneous group.

(JAMA. 2007;298(24):2912-2913. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including financial disclosures, funding and support, etc.


'/>"/>

Contact: Monique M. B. Breteler, M.D., Ph.D.
m.breteler@erasmusmc.nl
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
2. Stem cells derived from adult testes produce wide range of tissue types
3. Stem Cells From Testes Produce Wide Range of Tissue Types
4. Forget the Old Stereotypes - New Survey Reveals that Baby Boomers Are Feeling More Young and Active than Ever!
5. United Animal Nations Offers Financial Assistance Grants of up to $500 to Help Southern California Fire Victims Obtain Vet Care, Temporary Boarding for Pets
6. UniCare Announces Temporary Pharmacy Guidelines for Customers Affected by the California Wildfires
7. Homeless cells find temporary lodging -- and their demise
8. Aviva Belsky Promoted to Publisher of Contemporary Surgery
9. NYU study points to lasting impact of mild hearing loss on neurological processes
10. Special Conference: Women and Neurological Diseases
11. Kids Vaccine Ingredient Not Likely Linked to Neurological Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... , ... March 30, 2017 , ... According to the ... performed each year, putting it among the top 5 most popular minimally-invasive cosmetic procedures ... those million-plus procedures will be performed over the next 8-10 weeks. For anyone considering ...
(Date:3/30/2017)... ... March 30, 2017 , ... Nutrition Education for ... Dietetics (AND), will join nonprofit Seafood Nutrition Partnership (SNP) in presenting “Eating Heart ... to help nutrition educators and students inform consumers about the health benefits of ...
(Date:3/29/2017)... ... March 29, 2017 , ... ARI Network Services, Inc. (NASDAQ: ... co-op eligible dealer websites for its network of more than 650 U.S.-based dealers. Rhino, ... agricultural equipment including rotary and flail mowers and cutters, rear blades, post hole diggers, ...
(Date:3/29/2017)... ... ... Grass pollen is the main cause of hay fever in the United States, with an ... runs from May to July each year; with the worst time for sufferers being June ... balms ( http://www.haymax.us ) provide an effective defense against grass pollen; they are proven in ...
(Date:3/29/2017)... ... ... Sports Brand EXOUS Bodygear announced today a special sale price for the ... days of March, the price will be only $19.97. The EXOUS Bodygear 65cm ... (regular retail price $19.97). , The special promotional prices are to help individuals get ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Research and Markets has announced the addition of the ... report to their offering. ... Proton Therapy Market in Italy will double ... are currently three proton therapy centers in Italy ... Italy , the first patients were treated with proton beams ...
(Date:3/29/2017)... 2017  Providence Medical Technology, Inc., an innovator ... two industry veterans to the commercial leadership team.  ... to lead Global Marketing, and Michael Scott ... and Mr. Scott have over 40 years of ... joins the company with over 22 years of ...
(Date:3/29/2017)... , March 29, 2017  Glenmark Pharmaceuticals, ... for GSP 301, an investigational fixed-dose combination of ... mcg) administered twice-daily as a nasal spray being ... These results are from a recently completed Phase ... GSP 301 combination therapy versus mometasone, olopatadine or ...
Breaking Medicine Technology: