Navigation Links
Some muscular dystrophy patients at increased risk for cancer
Date:12/13/2011

People who have the most common type of adult muscular dystrophy also have a higher risk of getting cancer, according to a paper published today in the Journal of the American Medical Association.

The team found that patients who have myotonic muscular dystrophy are at increased risk primarily for four types of cancer: brain, ovary, colon, and the uterine lining known as the endometrium. The team also found a possible increased risk for some other types of cancer, including cancer of the eye, thyroid, pancreas, and other female reproductive organs.

Physicians estimate that approximately 40,000 Americans have myotonic dystrophy, an inherited disease that is marked by progressive muscle weakness. While the course of the disease varies from patient to patient, symptoms can include muscle stiffness, difficulty speaking and swallowing, problems walking, and in some patients, heart problems and cataracts.

Neurologists like study author Richard T. Moxley, M.D., of the University of Rochester Medical Center have long known that patients with myotonic dystrophy are at greater risk of a rare type of skin growth, and they know that skin cancer occurs more often as well in some families with the disease. Moxley teamed with cancer experts at the National Cancer Institute as well as scientists in Sweden and Denmark to study the link between muscular dystrophy and cancer more closely.

The team used detailed registries about the health of people with myotonic dystrophy to look closely at the records of 1,658 patients. Among that group, 104 people developed cancer twice the number of cases that would be expected in the overall population.

"Our findings suggest that patients with myotonic dystrophy need to be absolutely vigilant about cancer screening, particularly colon cancer screening," said Moxley, director of the University's Neuromuscular Disease Center and professor of Neurology. Moxley also heads the University's Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, one of six research centers funded by the National Institutes of Health.

Over the last 15 years, Moxley's colleague, Charles Thornton, M.D., has discovered how the genetic flaw at the root of myotonic muscular dystrophy a genetic repeat, a kind of molecular stutter actually causes the disease. He found that the flaw causes extra messenger RNA to accumulate in the nucleus of cells, making it difficult for a protein crucial for normal muscle growth to do its job.

Moxley notes that the genetic miscue that causes the disease is one that might also make cancer more likely to occur. The investigators say it's possible that the extra RNA may also hinder proteins involved in repairing DNA; a malfunction of DNA repair machinery is one way that cancer comes about. In addition, they note that the product made by the faulty gene is a close molecular relative of several cancer susceptibility genes.

The scientists say much more study is needed to understand the process. They plan to study the issue in more depth using a muscular dystrophy registry which includes about 1,600 patients with muscular dystrophy that has been compiled by Moxley and colleagues at Rochester, thanks to funding from the National Institutes of Health.


'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Type of Muscular Dystrophy Linked to Raised Cancer Risk
2. Wayne State University researcher to study spinal muscular atrophy
3. University Hospitals Neuromuscular Center EMG labs awarded accreditation
4. Most nurses dont use recommended intramuscular injection site despite potential risks
5. MDA awards $13.5 million in grants for research treatments for neuromuscular diseases
6. Human protein improves muscle function of muscular dystrophy mice
7. Fat yet muscular mouse provides clues to improving cardiovascular health
8. Blacks with muscular dystrophy die 10-12 years younger than whites: New study
9. Rochester leads international effort to improve muscular dystrophy treatment
10. Spinal muscular atrophy may also affect the heart
11. Gene Therapy Shows Promise for Muscular Dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
Breaking Medicine Technology: