Navigation Links
Some like it hot! Structure of receptor for hot chili pepper and pain revealed
Date:5/19/2008

You can now not only feel the spicy kick of a jalapeno pepper, you can also see it in full 3D, thanks to researchers at Baylor College of Medicine in Houston.

Using sophisticated equipment, the research team led by Dr Theodore G. Wensel, professor of biochemistry and molecular biology at BCM, generated the first three dimensional view of the protein that allows you to sense the heat of a hot pepper. The report appears in the current issue of the Proceedings of the National Academy of Sciences.

This protein, known as TRPV1, not only senses spicy foods, but also makes it possible to feel real heat and the pain and inflammation related to other medical conditions, said Wensel, senior author on the study. This method of viewing the protein now gives us the chance to clearly see the functional relationship between outside stimuli and the nerve cell.

The outside stimulus used in this study was the heat of a chili pepper. It has been known for years that the burning sensation results from the action of a chemical known as capsaicin on TRPV1 found on the nerve cell membrane. TRPV1 is an ion channel, a tiny pore on the cell membrane that allows chemicals such as calcium to flux in and out.

Any time you feel a burn or pain sensation, it is mediated by a TRPV1 channel. Different levels of heat are mediated by different TRP channels, said Dr. Vera Moiseenkova-Bell, a postdoctoral associate in Wensels laboratory at BCM and first author of the study. They are all related but each is regulated in a different manner.

Wensel said the three-dimensional image of TRPV1 revealed surprising information about its structure. It is made up of a pore domain embedded in the cell membrane, and a hanging basket of regulatory domains that extend into the interior of the cell.

Its an unusual thing. There is a whole hollow basket area but we dont know whats thats for, Wensel said. Now the search is on to understand how the basket area r
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. DATATRAK Announces Restructured Senior Management Team
2. Making the Outdoors Safer for Communities: the American Academy of Dermatology Announces 2008 AAD Shade Structure Program Grant Recipients
3. Complementary Excerpt Available from Best Practices: Resources, Structure and Processes to Optimize Pharmaceutical Sales Communications
4. ApothecaryRx Provides Exit Strategy for Boomer Pharmacy Businesses; Sustains Service and Communication Structure of Community Pharmacies to Improve Drug Compliance, Reduce Drug Errors
5. VaxGen Restructures Following Termination of Proposed Merger
6. Fetal Exposure to Substance Abuse Changes Brain Structure
7. International Health Leaders Address Globalization and Academic Health Center Infrastructure
8. Structure for Success: Leadership Development Programs at Pharmaceutical Companies
9. LifeMasters Strengthens Capital Structure with $15 Million in Funding from Existing Investors
10. Measurement technique probes surface structure of gold nanocrystals
11. University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... CA (PRWEB) July 12, 2014 For those ... are bodies can readily absorb the nutrients in food. The ... particles that are small enough to be absorbed by human ... team, a lack of enzymes in regular food is the ... a product that was started by Michelle DelPresto, a mother ...
(Date:7/12/2014)... “Critical Care Therapeutics in Major Developed ... PCCs and Recombinant Products to Drive Market,” which ... in the US, UK, France, Germany, Italy, Spain, ... of market size for 2013, along with market ... that are being treated using the five major ...
(Date:7/12/2014)... As reported in this July 1st ... Technology), the June 25th, 2014 Supreme Court ruling in Riley ... It was also met with both cheers and jeers ... was seen from an individual privacy perspective, or a law ... is now precedent which will require law enforcement officials to ...
(Date:7/12/2014)... July 12, 2014 Dubai is buzzing ... legend is heading to the UAE. The National ... will be in the UAE from 28-31 October to ... support of diabetes awareness. The event is being organized ... and event management company based in Dubai. The announcement ...
(Date:7/12/2014)... Texas (PRWEB) July 12, 2014 ... Breastfeeding Made Simple as a valuable new resource for ... roughly two-thirds of American women work away from their ... sources touting the benefits of breastfeeding, but often feel ... to nurse their babies. With its evidence-based insights, and ...
Breaking Medicine News(10 mins):Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 3Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 4Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 5Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2
... for the Cure,s Global Promise, DALLAS, Oct. ... the,leader of the global breast cancer movement, is ... Hewko as vice president of,international, reporting to Komen ... (Logo: http://www.newscom.com/cgi-bin/prnh/20070122/NYM084LOGO ), Hewko will guide ...
... Members who choose Regence,s,Health Savings Account (HSA) will ... company has added U.S. Bank as a banking partner. ... care banking,and its strong consumer track record., "We ... and,brand like U.S. Bank to offer our members the ...
... Barnett, London, Ontario, receives the Karolinska Stroke Award for ... SEK. The laureate will receive the prize from the ... Stroke Update meeting in Stockholm November 17, 2008. ... award. The Karolinska Institutet also awards the Nobel ...
... ANGELES, Oct. 29 George Abercrombie, president ... address Los Angeles,business leaders at the National ... He plans to tell them,that the threat ... challenges,unlike those anticipated with traditional emergency preparedness ...
... Cojocaru forms Team Cojo to fight PKD, ... own life-saving,kidney transplant, fashion critic and Entertainment Tonight ... the 12.5 million people,worldwide affected by Polycystic Kidney ... world,s most common, life-threatening genetic,diseases, affecting more people ...
... Health Literacy Month, recognized in October, promotes ... information. According to the National Assessment of Adult ... health literacy - skills needed to manage their ... the focus of an ongoing study at the ...
Cached Medicine News:Health News:Susan G. Komen for the Cure(R) Strengthens Global Mission With Addition of Vice President, International 2Health News:Susan G. Komen for the Cure(R) Strengthens Global Mission With Addition of Vice President, International 3Health News:Regence Teams With U.S. Bank to Offer New Health Savings Account Solution 2Health News:Dr. Henry Barnett becomes first person outside Europe to receive Karolinska Stroke Award 2Health News:CEO to Address Los Angeles Business Leaders About Developing Pandemic and Business Continuity Plans 2Health News:CEO to Address Los Angeles Business Leaders About Developing Pandemic and Business Continuity Plans 3Health News:Cojo to Hit the Streets of LA for 2008 Walk for PKD 2Health News:$8.6 million grant to MU will fund efforts to improve health literacy, health outcomes 2
(Date:7/11/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/tjlw9k/immunoprotein ... "Immunoprotein Diagnostic Testing Market - Forecasts to 2019: ... 6% and is expected to be valued at ... http://photos.prnewswire.com/prnh/20130307/600769 ... been segmented according to immunoprotein types which include ...
(Date:7/10/2014)... , July 11, 2014  Major advances in ... cancer are being highlighted in a three-day Oncology ... from 10-12 July, 2014.  Renowned national and international cancer ... best practices and exchange knowledge on modern technologies ... and efficient. The Summit will ...
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon Solution, ... advanced memory and analog IC solutions, today announced that ... July 24, 2014, at 7:00 a.m. Pacific Time (10:00 ... for the fiscal 2014 third quarter ended June 30, ... telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time on ...
Breaking Medicine Technology:Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5
... Calif., Jan. 5, 2011 BioMarin Pharmaceutical Inc. (Nasdaq: ... Officer of BioMarin, will present a company update at the ... Monday, January 10, 2011 at 2:30 p.m. PT.   ... the conference call via the investor section of the BioMarin ...
... 5, 2011 Ikaria, Inc. today announced that the ... (nitric oxide) for inhalation an additional six months of ... exclusivity for INOMAX from January 2013 to July 2013. ... clinical trials of INOMAX in pre-term infants at risk ...
Cached Medicine Technology:BioMarin to Present at the J.P. Morgan 29th Annual Healthcare Conference 2FDA Extends Marketing Exclusivity for INOMAX® 2FDA Extends Marketing Exclusivity for INOMAX® 3
... fixed pipette is ideal for ... volume. Fixed volume FInnpipettes offer ... as other Finnpipette Digital pipettes: ... blow-out (1-40ul), Soft-touch tip ejection, ...
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
Inquire...
Inquire...
Medicine Products: