Navigation Links
Some diabetes drugs may increase risk of bladder cancer
Date:7/3/2012

An increased risk of bladder cancer is linked to the use of pioglitazone, a medication commonly used to treat type 2 diabetes, according to a new study published in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/site/press/cmaj112102.pdf

People with type 2 diabetes are at risk of several types of cancer, including a 40% increased risk of bladder cancer, compared to people without diabetes. Previous studies have shown a higher incidence of bladder cancer in people taking pioglitazone, a type of thiazolidinedione.

To determine whether there is a link between pioglitazone use and bladder cancer, researchers conducted a systematic review and meta-analysis of randomized controlled trials and observational studies involving over 2.6 million patients.

"We observed an increased risk of bladder cancer associated with the use of thiazolidinediones," writes Dr. Jeffrey Johnson, School of Public Health, University of Alberta, with coauthors. "In particular, use of pioglitazone was associated with an increased risk of bladder cancer based on a pooled estimate from three cohort studies involving more than 1.7 million individuals."

The researchers also looked at a possible association with rosiglitazone, another type of thiazolidinedione, but did not see an effect.

"Although the absolute risk of bladder cancer associated with pioglitazone was small, other evidence-based treatments for type 2 diabetes may be equally effective and do not carry a risk of cancer," conclude the authors. "This study quantifies the association between pioglitazone use and bladder cancer and may help inform decisions around safer use of pioglitazone in individuals with type 2 diabetes."


'/>"/>

Contact: Kate Toogood
kate.toogood@ualberta.ca
780-492-4645
Canadian Medical Association Journal
Source:Eurekalert

Page: 1

Related medicine news :

1. How a cancer drug leads to diabetes
2. Heart failure patients with diabetes may benefit from higher glucose levels
3. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
4. Mouse Study Hints at New Path for Diabetes Treatment
5. Common Plastics Chemical Might Boost Diabetes Risk
6. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Cellular pathway linked to diabetes, heart disease
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
11. Xenotransplantation as a therapy for type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... ... June 23, 2016 , ... vcfo, a consulting firm that ... to announce the promotion of Mike Mackey to Regional Vice President of Southeast ... was responsible for managing client projects and overseeing vcfo financial consultants in the ...
(Date:6/23/2016)... ... ... Virginia Beach resident Sean Kelly suffered from depression after a long military career ... set out to accomplish a personal mission: a solo 50-mile paddle. Kelly decided to ... the story of another special operations veteran, Josh Collins, whom Kelly had served with ...
(Date:6/23/2016)... ... June 23, 2016 , ... Horizon Blue Cross Blue ... seeking relief from the crushing burden of sky-high health care costs, Superior Court ... their ruling ( http://www.judiciary.state.nj.us/opinions/a2913-15a2929-15.pdf ) the court provided some analysis of the ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... has been approved to train physicians within its Graduate Medical Education program, this ... (ACGME) means MHS can begin enrolling doctors for residency training that will begin ...
(Date:6/23/2016)... , ... June 23, 2016 , ... King Kullen’s Shop ... offering service to yet another location: Garden City Park. This is the fourth store ... , Online grocery delivery service is offered by King Kullen and allows customers to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Consumers have taken a more active ... more emphasis on patient outcomes. ... the pharmaceutical industry have evolved beyond just providing ... are focusing on becoming more patient-oriented across their ... services that improve health. ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
Breaking Medicine Technology: