Navigation Links
Some diabetes drugs may increase risk of bladder cancer
Date:7/3/2012

An increased risk of bladder cancer is linked to the use of pioglitazone, a medication commonly used to treat type 2 diabetes, according to a new study published in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/site/press/cmaj112102.pdf

People with type 2 diabetes are at risk of several types of cancer, including a 40% increased risk of bladder cancer, compared to people without diabetes. Previous studies have shown a higher incidence of bladder cancer in people taking pioglitazone, a type of thiazolidinedione.

To determine whether there is a link between pioglitazone use and bladder cancer, researchers conducted a systematic review and meta-analysis of randomized controlled trials and observational studies involving over 2.6 million patients.

"We observed an increased risk of bladder cancer associated with the use of thiazolidinediones," writes Dr. Jeffrey Johnson, School of Public Health, University of Alberta, with coauthors. "In particular, use of pioglitazone was associated with an increased risk of bladder cancer based on a pooled estimate from three cohort studies involving more than 1.7 million individuals."

The researchers also looked at a possible association with rosiglitazone, another type of thiazolidinedione, but did not see an effect.

"Although the absolute risk of bladder cancer associated with pioglitazone was small, other evidence-based treatments for type 2 diabetes may be equally effective and do not carry a risk of cancer," conclude the authors. "This study quantifies the association between pioglitazone use and bladder cancer and may help inform decisions around safer use of pioglitazone in individuals with type 2 diabetes."


'/>"/>

Contact: Kate Toogood
kate.toogood@ualberta.ca
780-492-4645
Canadian Medical Association Journal
Source:Eurekalert

Page: 1

Related medicine news :

1. How a cancer drug leads to diabetes
2. Heart failure patients with diabetes may benefit from higher glucose levels
3. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
4. Mouse Study Hints at New Path for Diabetes Treatment
5. Common Plastics Chemical Might Boost Diabetes Risk
6. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Cellular pathway linked to diabetes, heart disease
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
11. Xenotransplantation as a therapy for type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... 31, 2016 , ... Spectrum Aquatics has launched a brand new ADA pool ... built with the user in mind. , “Over the last two years our key ... ADA 400 lbs lift is a necessary requirement for certain facilities with specific needs,” ...
(Date:5/31/2016)... ... ... Interest is on the rise for using the CRISPR-Cas9 system for functional ... hit validation. A key reason may be that high-throughput synthesis—combined with a proprietary algorithm ... collections in arrayed formats. , Arrayed crRNA screens have the advantage ...
(Date:5/31/2016)... ... ... TeaZa® Energy, LLC announces the launch of a new limited ... . The new flavor—Tropical TeaZa? Energy—will be available to customers exclusively online starting ... flavor is best described as a juicy, taste bud takeover. A mouthwatering wave ...
(Date:5/31/2016)... ... May 31, 2016 , ... MinerEye today announced that it ... Protection report by Gartner1 Inc. , Each year, Gartner identifies new Cool Vendors ... innovative vendors and their products and services. , According to Gartner, “Gartner's Cool ...
(Date:5/31/2016)... IL (PRWEB) , ... May 31, 2016 , ... ... multichannel marketing services firm and statement solutions provider, for the tenth ... in the May 2016 issue of Advertising Age, and SourceLink ranked eighteenth in ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... , May 30, 2016 ... H1 2016" market research report with comprehensive information ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:5/27/2016)... 2016 According to the 2016 ... driving ambulatory blood pressure monitoring system market growth. With ... ability to respond to different pressure rates, leading to ... to various cardiovascular disorders such as heart failure, stroke, ... are growing in prevalence each year. WHO estimates that ...
(Date:5/27/2016)... , May 27, 2016 The ... manufacturers, health insurance companies all falling under its umbrella.  ... companies. While not often talked about, these healthcare companies ... United States is by far the largest ... Medical Isotope Corp. (OTC: ADMD), Nutranomics Inc. (OTC: NNRX), ...
Breaking Medicine Technology: