Navigation Links
Some cancer mutations slow tumor growth
Date:2/4/2013

CAMBRIDGE, MA -- A typical cancer cell has thousands of mutations scattered throughout its genome and hundreds of mutated genes. However, only a handful of those genes, known as drivers, are responsible for cancerous traits such as uncontrolled growth. Cancer biologists have largely ignored the other mutations, believing they had little or no impact on cancer progression.

But a new study from MIT, Harvard University, the Broad Institute and Brigham and Women's Hospital reveals, for the first time, that these so-called passenger mutations are not just along for the ride. When enough of them accumulate, they can slow or even halt tumor growth.

The findings, reported in this week's Proceedings of the National Academy of Sciences, suggest that cancer should be viewed as an evolutionary process whose course is determined by a delicate balance between driver-propelled growth and the gradual buildup of passenger mutations that are damaging to cancer, says Leonid Mirny, an associate professor of physics and health sciences and technology at MIT and senior author of the paper.

Furthermore, drugs that tip the balance in favor of the passenger mutations could offer a new way to treat cancer, the researchers say, beating it with its own weapon mutations. Although the influence of a single passenger mutation is minuscule, "collectively they can have a profound effect," Mirny says. "If a drug can make them a little bit more deleterious, it's still a tiny effect for each passenger, but collectively this can build up."

Lead author of the paper is Christopher McFarland, a graduate student at Harvard. Other authors are Kirill Korolev, a Pappalardo postdoctoral fellow at MIT, Gregory Kryukov, a senior computational biologist at the Broad Institute, and Shamil Sunyaev, an associate professor at Brigham and Women's.

Power struggle

Cancer can take years or even decades to develop, as cells gradually accumulate th
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. New Stool Test Might Aid in Early Detection of Colon Cancer
3. Study reveals how cancer drug causes diabetic-like state
4. How a cancer drug leads to diabetes
5. You Survived Cancer: Now Pay Attention to Your Overall Health
6. New drug prevents spread of human prostate cancer cells
7. Eliminating the good cholesterol receptor may fight breast cancer
8. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
9. Experimental Chemo Combo for Colon Cancer Disappoints
10. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
11. Targeted therapeutics for colon cancer to be presented at AACR meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... SATURDAY, May 18 (HealthDay News) -- Children who swallow ... to remove the objects, according to a new study. ... Center in New Orleans, found that more than 79 ... required either surgery or an endoscopic procedure, in which ... digestive tract. Only 21 percent of these cases can ...
(Date:5/18/2013)... published an original art book for iPad with tango as ... who share their creations based on the traditional music genre ... iPad . , This work gathers more than 150 ... signature idiosyncrasy and passion of tango. Such book is ... it includes a free trailer of the book for readers ...
(Date:5/18/2013)... 2013) There are significant cost and risk ... diagnose or treat gastrointestinal problems, according to research ... A study by New York Presbyterian Hospital and ... may substantially reduce the cost and risk of ... believed to affect nearly 25 percent of adults, ...
(Date:5/18/2013)... In a May 14, 2013 article entitled ... Discovering Cancer Gene,” Fox News reported the movie star ... she carried a gene that doctors estimated gave her ... 50 percent risk of ovarian cancer (go to: goo.gl/5JHBP). ... 2013 with a blog post entitled “A Patient’s Journey: ...
(Date:5/18/2013)... A ground-breaking advance in colonoscopy technology signals ... presented today at Digestive Disease Week (DDW). Additional ... for colonoscopies and exploring safer methods for removing ... a device called a colonoscope to examine the ... a doctor to look for precancerous polyps called ...
Breaking Medicine News(10 mins):Health News:Swallowing Magnets Can Be Fatal for Children 2Health News:New Art Book for iPad: Tango Art 2Health News:New research identifies practice changes to improve value and quality of GI procedures 2Health News:Angelina Jolie – Scarless Breast Augmentation Surgery 2Health News:New colonoscope provides ground-breaking view of colon 2Health News:New colonoscope provides ground-breaking view of colon 3Health News:New colonoscope provides ground-breaking view of colon 4
... Stockholm, Sweden: Melanoma of the eye (ocular or uveal melanoma) ... there is no effective treatment and patients die within an ... ten patients live for a year. Now, final results from ... significantly extends the time patients can live without the disease ...
... People,s bodies build up vitamin D through exposure to sunlight, ... areas of the United States with low sunlight are more ... in the same places. The researchers say the findings ... study shows that across-the-board vitamin D recommendations just won,t work ...
... FRIDAY, Sept. 23 (HealthDay News) -- Foreign-born U.S. women are ... cancer, but native-born women still outpace them, a new study ... mammography among foreign-born women in the United States, but there ... their use of recommended breast cancer screening," study lead researcher ...
... disabilities increased in the U.S. among non-elderly adults during ... Mojtabai, MD, PhD, of the Johns Hopkins Bloomberg School ... found the prevalence of disability attributed to other chronic ... remained unchanged. The findings will appear in the November ...
... A little motivation for parents could go a long ... their own care, a Wayne State University researcher believes. ... in WSU,s School of Medicine, has received a two-year, ... Digestive and Kidney Diseases of the National Institutes of ...
... News) -- Many people who undergo MRI scans describe feeling ... and a new study may explain why. Researchers ... on fluid circulating in the inner ear, impacting balance and ... , In the study, published online Sept. 22 in ...
Cached Medicine News:Health News:Infusing chemotherapy into the liver gives extra months of disease-free life in melanoma patients 2Health News:Infusing chemotherapy into the liver gives extra months of disease-free life in melanoma patients 3Health News:Infusing chemotherapy into the liver gives extra months of disease-free life in melanoma patients 4Health News:Many Black Men in Cold Climates Lack Vitamin D 2Health News:Wayne State University study aims to improve diabetes management in high-risk youth 2Health News:Wayne State University study aims to improve diabetes management in high-risk youth 3Health News:Magnetic Field May Cause MRI-Induced Vertigo 2
(Date:5/16/2013)... , May 16, 2013  HeartWare International, Inc. (NASDAQ: ... of less invasive, miniaturized circulatory support technologies that are revolutionizing ... Doug Godshall is scheduled to present ... EDT on Monday, May 20, 2013.  The conference is being ... A live webcast of the Company,s presentation at ...
(Date:5/16/2013)... OAKS, Calif. , May 16, 2013  Amgen (NASDAQ: ... Life Sciences Conference on Tuesday, May 21, 2013, at the ... City , beginning at 10:00 a.m. Eastern Daylight Time. ... vice president of Research and Development at Amgen, will present ... accessed from the Events Calendar on Amgen,s website, www.amgen.com ...
(Date:5/16/2013)... , May 16, 2013 ... in the U.S. to access the widely-used OrthoView digital ... PC and Internet connection to get started. ... software for over 10 years, is dedicated to enabling ... with digital x-ray images, when printed film is unavailable. ...
Breaking Medicine Technology:HeartWare Presentation At The 2013 UBS Global Healthcare Conference To Be Webcast 2OrthoView Announces the U.S. Launch of a New, Subscription-based, Digital Planning and Templating Solution for Individual Orthopaedic Surgeons 2
... ERBITUX (cetuximab), the,first approved IgG1 monoclonal antibody ... and commercialized by,ImClone Systems Incorporated, was the ... at the recently concluded 43rd Annual Meeting,of ... This year's ASCO ERBITUX presentations showcased the ...
... attack,comparable to two widely used diabetes medicines , ... June 6, 2007 - A study,of more than 33,000 type ... study shows that the incidence of,hospitaliations for heart attack, and/or ... Avandia is the,same as for other diabetes treatments. The ...
Cached Medicine Technology:Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 2Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 3Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 4Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 5Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 6Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 7Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 8Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 9Extensive Clinical Data on Erbitux Presented at the 2007 ASCO,Annual Meeting 10Newly Published Data from Large Study Support Cardiovascular Safety,of Avandia (Rosiglitazone Maleate) 2Newly Published Data from Large Study Support Cardiovascular Safety,of Avandia (Rosiglitazone Maleate) 3Newly Published Data from Large Study Support Cardiovascular Safety,of Avandia (Rosiglitazone Maleate) 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: