Navigation Links
Some bacteria may protect against disease caused by stomach infection
Date:3/12/2013

Half of the world's human population is infected with the stomach bacteria called Helicobacter pylori, yet it causes disease in only about 10 percent of those infected. Other bacteria living in the stomach may be a key factor in whether or not H. pylori causes disease, according to a new study led by scientists at the University of California, Santa Cruz.

"People tend to think of the stomach as a relatively sterile environment, but it's actually populated with microbes," said Karen Ottemann, professor and chair of microbiology and environmental toxicology at UC Santa Cruz.

Researchers in Ottemann's lab were studying H. pylori infections in mice when they noticed that mice from two different suppliers had different responses to the infection, even though they were the same mouse strain and therefore genetically identical. Examining the bacteria in the stomachs of the mice (the stomach "microflora"), they found differences between the mice from different suppliers. They then used antibiotics to alter the stomach microflora in mice from a single supplier and again found changes in the response to H. pylori.

"We found that something about the preexisting microflora, before H. pylori comes into the mouse, changes the mouse's response to the infection," Ottemann said.

The findings, published in the journal Infection and Immunity, have potential implications for treating human infections. The bacteria in the stomachs of mice and humans are broadly the same--not necessarily at the species level, but the same types of bacteria are present in both, Ottemann said.

H. pylori infections can cause ulcers and stomach cancer, but most infected people don't develop any disease. Furthermore, there is evidence that H. pylori infection can protect against diseases such as esophageal cancer and asthma. For these reasons, people are only treated for the infection if they develop symptoms. With a better understanding of the effects of the stomach microflora, it might be possible to predict whether someone is likely to develop disease and should be treated for an H. pylori infection.

"It would be nice if we could predict who would get disease," Ottemann said. "The other possibility is that we might be able to identify some bacteria that could be used as a probiotic to dampen H. pylori disease."

At this point, it is not clear which bacteria are responsible for changing the response to H. pylori infection in mice. Focusing on mice from one supplier, Ottemann's team used genetic profiling techniques to identify more than 10,000 different types of bacteria present in mouse stomachs, of which about 2,000 were found in all the mice sampled.

The researchers treated some of the mice with antibiotics, which did not eliminate stomach bacteria but substantially changed the composition of the gut microflora. The altered microflora dampened the inflammatory response to H. pylori infection. When they looked for differences in the stomach microfloras of mice with and without inflammatory disease, the researchers found more than 4,000 differences--either species present in one group and not in the other, or differences in the abundances of certain species.

More work is needed to identify which differences in bacterial composition are responsible for the differences in response to H. pylori, Ottemann said. "The results do point to some potential candidates for a protective effect, such as Clostridium species, some of which are known to influence inflammation in the intestine," she said.


'/>"/>
Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz
Source:Eurekalert

Related medicine news :

1. Nightmare Bacteria Spreading in U.S. Hospitals, Nursing Homes: CDC
2. Bacterial Vaginosis Treatment
3. How “BV Miracle” Helps Women Cure Bacterial Vaginosis Permanently – Health Reviews
4. With Acne, Bacteria Strain on Your Skin May Be Culprit
5. UV-Aid New Technology Utilizes Hydroxyls to Eliminate Bacteria and Viruses Helping Prevent Colds, Flu, and Ear Infections
6. Strains of antibiotic-resistant Staph bacteria show seasonal preference; Children at higher risk in summer
7. New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
8. Study identifies factors associated with eradication of bacteria linked to gastric cancer
9. C-Section, Formula May Disrupt Good Gut Bacteria in Babies
10. Scientists find key to growth of bad bacteria in inflammatory bowel disease
11. Human bacteria sequencing project involving CU raises $340,000 online
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... , ... April 29, 2016 , ... Spine Team Texas, ... is proud to announce one of their physicians has been invited to be a ... (Texas ACOFP) Family Practice Review conference on April 30, 2016. , Dr. R. ...
(Date:4/29/2016)... ... 29, 2016 , ... World Patent Marketing , a ... invention which aids in proper muscle development. , "The Gym & Exercise Equipment ... of World Patent Marketing. "Globalization has threatened the future growth of the industry ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Robert Mondavi, one of ... improve smiles. Cosmetic dentistry is a fast-growing field as more patients are discovering the ... to learn more about the options currently available to them and which ones might ...
(Date:4/29/2016)... , ... April 29, 2016 , ... For those who ... the meal to miss. That was among the many new lifestyle diet tips offered ... recent Sharon Kleyne Hour® Power of Water® radio show. Bonny and Lawrence noted that ...
(Date:4/29/2016)... ... 2016 , ... Regenerative Medicine Solutions (RMS) scored 94.8124 out of ... them second place for Tampa’s Best Places to Work. They were ranked in the ... great accomplishment for our team,” says RMS Human Resources Manager Irene Miller. “We work ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 TapImmune,Inc. (TPIV), a ... and gene-based immunotherapeutics and vaccines for the treatment of cancer ... the 3rd Annual Growth Capital Expo to be ... at Caesars Palace in Las Vegas, Nevada.  The Company ... 4 th by Dr. John N. Bonfiglio ...
(Date:4/27/2016)... 2016  Hologic, Inc. (Nasdaq: HOLX ... the fiscal second quarter ended March 26, 2016.  ... increased 41.2%, and non-GAAP diluted EPS of $0.47 ... on a reported basis, and 6.3% on a ... another good quarter, highlighted by 14.6% growth in ...
(Date:4/27/2016)... , le 27 Avril 2016 ... d,affaires a progressé de +5% sur le trimestre, ... récurrentes de consommables  Croissance de +16% ... Mauna Kea Technologies (Euronext : MKEA, ... d,endomicroscopie confocale laser, annonce aujourd,hui son chiffre d,affaires ...
Breaking Medicine Technology: