Navigation Links
Some Whooping Cough Strains Now Outsmarting Vaccine
Date:2/7/2013

By Serena Gordon
HealthDay Reporter

WEDNESDAY, Feb. 6 (HealthDay News) -- The bacteria responsible for whooping cough may be evolving into different strains, and the current vaccine can't offer complete protection against these new strains, researchers report.

In recent years, cases of whooping cough have risen dramatically. Tens of thousands have been sickened, and 18 deaths have been reported, mostly in infants, according to the U.S. Centers for Disease Control and Prevention.

Several recent studies have focused on the potential of waning immunity from the whooping cough vaccine over time. In a letter in the Feb. 7 issue of the New England Journal of Medicine, researchers pointed out that there may be another culprit: an evolution in the bug itself.

The vaccine contains a number of components that help give the body immunity against the whooping cough bacteria (Bordetella pertussis). One of these components is called pertactin.

Strains of the whooping cough bacteria that are pertactin-negative have been found in Japan, France, Finland and, now, the United States, the researchers reported in the letter. That means that at least one component of the current vaccine is ineffective against these newly found strains.

"There are several theories as to why we're seeing more pertussis," said Dr. Kenneth Bromberg, chairman of pediatrics and director of the Vaccine Research Center at the Brooklyn Hospital Center, in New York City. "One theory is better diagnosis. A second [theory] is that the vaccines are not as good in terms of longevity as the whole-cell vaccine was. The third theory is that there have been genetic changes in the strains of pertussis, such that it makes new strains immune or relatively immune to the current vaccines."

"The thought is that the bacteria have gotten smart and are eliminating the pertactin in themselves," said Bromberg, who was not involved in the current research.

A second letter in the same journal issue addressed another of the theories that Bromberg outlined: the effectiveness of the current vaccine.

In the late 1990s, the vaccine was switched from a whole-cell vaccine to what's known as an acellular vaccine.

"The whole-cell vaccine contains the whole cell of killed bacteria, so every protein that the bacteria makes is in it, forcing the person to mount an immune response to every part of the bacteria," said the letter's co-author, Dr. Paul Cieslak, medical director of the Oregon Immunization Program, in Portland. "With the new, acellular vaccine, they picked the proteins they thought were most important. Without the whole cell, there are fewer side effects, but it may be a little less effective."

Oregon experienced a significant increase in the number of whooping cough cases last year. Oregon maintains statewide records on immunizations, as well as records of who has had a confirmed case of whooping cough. This information allowed Cieslak and his colleagues to go back and review what type of vaccine had been given to those who later were infected with whooping cough.

They found that the reported cases of whooping cough were significantly lower in youngsters who had their first immunization with the whole-cell vaccine rather than the acellular vaccine.

Does that mean that whole-cell vaccine should make a comeback? "No one is making the argument for whole-cell vaccine," Cieslak said. "Without the whole cell in the vaccine, there are fewer side effects. It may be a little less effective, but it's got to be safe."

Bromberg agreed. "The whole-cell vaccine isn't coming back. The acellular vaccine is significantly better in terms of not causing reactions, but it doesn't work for as long as we thought," he said.

Cieslak said that even though the current vaccine isn't perfect, "we certainly recommend getting the vaccine. You are still far better off with the vaccine."

Bromberg added that experts are trying to figure out ways to better use the current vaccine. For example, the CDC recently added a recommendation that all pregnant women should receive the whooping cough vaccine late in pregnancy to offer protection to their newborns.

More information

Learn more about preventing whooping cough from the U.S. Centers for Disease Control and Prevention.

SOURCES: Paul Cieslak, M.D., medical director, Oregon Immunization Program, Portland, Ore.; Kenneth Bromberg, M.D., chairman of pediatrics and director of the Vaccine Research Center, Brooklyn Hospital Center, New York City; Feb. 7, 2013, New England Journal of Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Whooping Cough Vaccine for Pregnant Women Among New Recommendations
2. Technique IDs Deadliest Whooping Cough Cases
3. Findings support safety of whooping cough vaccine for older adults
4. Whooping Cough Vaccine Less Effective Over Time: Study
5. CDC Panel: All Pregnant Women Should Get Whooping Cough Shot
6. Whooping Cough Vaccine Protection Fades Over Time: Study
7. Is Improved Vaccine Causing Whooping Cough Outbreaks?
8. Whooping Cough Cases Reaching Record Highs: CDC
9. What did we learn from the 2010 California whooping cough epidemic?
10. Patient Education Helps Prevent Overuse of Antibiotics for Cough, Study Finds
11. Many People Underestimate How Long a Cough Should Last
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Some Whooping Cough Strains Now Outsmarting Vaccine
(Date:8/22/2017)... ... ... “Call Of Spiritual Duty”: a revelation in an era defined by intentional ... Growing up on the streets of North Visalia, California, Carlos Lizarde quickly became familiar ... keys to his life, he noticed immediately that opportunities and blessings began to shift ...
(Date:8/21/2017)... ... August 22, 2017 , ... Nanoparticle research provides an exciting ... By learning and implementing best practices for containment using ventilated safety enclosures, many ... gain a better understanding of a method for safely testing nanotechnology hoods. They ...
(Date:8/21/2017)... ... August 21, 2017 , ... FCPX LUT Monochromatic Volume 2 is ... and easily add washed color grades to footage. A LUT is a Lookup Table ... color to the corresponding color indicated by the table. This pack comes with 60 ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... place all over the country. , Outdoor running increases exposure to ultraviolet radiation, ... an increased risk of melanoma, and only half may be adequately protecting themselves ...
(Date:8/21/2017)... New York, NY (PRWEB) , ... August 21, 2017 , ... ... healthcare brands, was recently named one of the Top 100 agencies of the year ... list in MM&M’s annual agency issue, marking an important milestone for the agency. ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... GAITHERSBURG, Md. , Aug. 7, 2017 /PRNewswire/ ... for healthcare member acquisition, retention, and engagement, announced ... Director of Strategy and Product Development, effective as ... strategic consulting and technology implementation strategy for our ... years of experience in consulting and business analytics ...
(Date:8/4/2017)... , Aug. 4, 2017 The search ... shortly after a physician/patient consult has long been the ... was a notable focus of the largest meeting of ... according to healthcare market research firm Kalorama Information.  The ... testing (POCT) offerings or related supplies and software were ...
(Date:8/2/2017)... 2, 2017  Life Flight Network and PeaceHealth Oregon Network ... patient care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, ... and Life Flight Network work collaboratively to move patients who ... when a time sensitive emergency exists. ...
Breaking Medicine Technology: