Navigation Links
Some Weight-Loss Drugs Might Disrupt Brain Growth in Kids
Date:5/7/2008

Cannabinoid-blocking receptors thwarted rewiring needed for neural development, mouse study shows

WEDNESDAY, May 7 (HealthDay News) -- A new class of weight-loss drugs that suppresses appetite by blocking cannabinoid receptors in the brain should be used with caution in children, U.S. scientists report.

In research with mice, they found this class of drugs also suppresses the adaptive rewiring of the brain necessary for neural development in young animals. The findings are in the May 8 issue of Neuron.

One such drug is rimonabant (Acomplia), which was developed by Sanofi-Aventis and is awaiting approval by the U.S. Food and Drug Administration. Other pharmaceutical companies are developing similar drugs.

In this study, researchers concluded that a cannabinoid receptor-blocking drug called AM 251 affected experience-dependent cortical plasticity in the brains of juvenile mice. This plasticity is the experience-prompted adaptive rewiring of the brain that plays an critical role in the neural development of young animals.

"Our finding of a profound disruption of cortical plasticity in juvenile mice treated with AM 251 suggests caution is advised in the use of such compounds in children," wrote Mark F. Bear and his colleagues, of the Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, in Cambridge, Mass.

More information

The Nemours Foundation has more about childhood obesity.



-- Robert Preidt



SOURCE: Cell Press, news release, May 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Weight-Loss Surgeries Extend Lives
2. UMass Medical School study identifies the best weight-loss plans for heart health
3. FTC Attacks Infomercial Marketer to Silence Best-Selling Authors Weight-Loss Tips
4. Psychiatric Woes Can Postpone Weight-Loss Surgery
5. Studies Examine Life After Weight-Loss Surgery
6. NutriSystem Advances Weight-Loss Category
7. New Weight-Loss Drug Shows Promise in Early Study
8. USA TODAY Weight-Loss Challenge Returns For 5th Year With Eight Weeks of Compelling Stories and Online Features
9. New review suggests caution on drugs to raise good cholesterol
10. Can cancer drugs combine forces?
11. Study provides hope that some transplant patients could live free of antirejection drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Some Weight-Loss Drugs Might Disrupt Brain Growth in Kids
(Date:4/30/2016)... ... 2016 , ... “Aging well is a challenge for all of us, but there are things we can do ... . “Research is showing more and more that there are simple, yet important steps that ... we age.” Top priorities Dr. Kohli’s recommends for her patients include;, , ...
(Date:4/29/2016)... ... April 29, 2016 , ... Since ... the national charitable foundation serving the footwear industry, has broken all previous participation ... than 130 companies across 23 states during the months of April and May, ...
(Date:4/29/2016)... ... 29, 2016 , ... The American workforce is on everyone’s ... Most importantly, employees are the single most important asset in creating value and ... , Just under half of American workers are emotionally checked out with low ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... surgeon reveals that infants born with severe congenital diaphragmatic hernia have better survival ... born with congenital diaphragmatic hernia (CDH)—a condition where the diaphragm fails to form ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... Association (CCA), is pleased to announce the launch of the GFCP Scoop ... recipes, and more. The purpose of the GFCP Scoop site is ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... MARLBOROUGH, Mass., April 27, 2016  Hologic, Inc. ... Company,s financial results for the fiscal second quarter ... share (EPS) of $0.24 increased 41.2%, and non-GAAP ... $693.3 million increased 5.8% on a reported basis, ... "We posted another good quarter, highlighted ...
(Date:4/27/2016)... PARIS , le 27 Avril 2016 /PRNewswire/ ... chiffre d,affaires a progressé de +5% sur le ... ventes récurrentes de consommables  Croissance de ... Mauna Kea Technologies (Euronext : ... multidisciplinaire d,endomicroscopie confocale laser, annonce aujourd,hui son chiffre ...
(Date:4/27/2016)... Italy , April 27, 2016 ... linear accelerator (MR-linac) platform will be the focal point ... meeting of the European Society for Radiotherapy & Oncology, ... Elekta,s MR-linac integrates a state-of-the-art radiotherapy system and a ... physician to clearly see the patient,s anatomy in real ...
Breaking Medicine Technology: