Navigation Links
Some Severe MS Flares Helped by Blood Filtering Treatment
Date:1/17/2011

By Jenifer Goodwin
HealthDay Reporter

MONDAY, Jan. 17 (HealthDay News) -- A blood-filtering procedure called plasma exchange helps ease severe flares of multiple sclerosis (MS), but does not help with more advanced, progressive forms of the disease, new guidelines say.

Plasma exchange, or plasmapheresis, is also effective in treating severe forms of Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy and it may be considered to treat some other kinds of inflammatory neuropathies, according to the American Academy of Neurology guidelines.

Periodically, the academy reviews the available research on various procedures, ranks the evidence according to quality of the research and issues new recommendations that many neurologists use in their practice.

The updated guidelines, based on a review of research published between 1995 and 2009, are published in the Jan. 18 issue of Neurology. The previous guidelines were issued in 1996.

"With multiple sclerosis, plasmapheresis works, but only with the acute attacks, and it should also be used only when steroids do not work," said guidelines co-author Dr. Vinay Chaudhry, a professor of neurology at Johns Hopkins University School of Medicine. "If the MS is chronic or progressive, not the relapsing or remitting type, plasmapheresis does not work."

In plasma exchange, developed in the 1970s, a patient's blood is removed from the body and filtered. The patient's blood and platelets are returned, but the plasma is replaced with donor plasma.

Though physicians aren't entirely sure why plasma exchange works, it's generally believed that filtering removes harmful proteins and antibodies in the plasma that attack the central nervous system.

Multiple sclerosis is an autoimmune disease in which the body's own immune system attacks myelin, or the sheath that insulates nerve fibers of the central nervous system. The damage disrupts nerve signals traveling to and from the brain, which can lead to numbness, movement difficulties, blurred vision, fatigue and cognitive issues.

About 85 percent of those with MS start with a relapsing-remitting course, in which attacks are followed by partial or total recovery. Eventually, more than half go on to develop a more progressive form of the disease with fewer and shorter symptomless periods.

At the outset of the disease, doctors usually treat MS flares with steroids, said Dr. Lily Jung, medical director of the neurology clinic at the Swedish Neuroscience Institute in Seattle.

According to the guidelines, if the attack is particularly severe and the steroids are not helping, doctors should consider using plasma exchange.

However, the treatment is not effective for more advanced and aggressive forms of the disease, including chronic or secondary progressive forms, the guidelines say.

Researchers also looked at the evidence for the use of plasma exchange for other neurologic disorders, including myasthenia gravis and pediatric autoimmune neuropsychiatric disorders associated with streptococcus infection, but there was not enough evidence to determine whether it is an effective treatment.

The recommendations make sense, Jung said. Plasmapheresis can be grueling and generally requires a hospital stay of about 10 days. Complications can include infection and blood clots, so it should be reserved for patients with a severe flare, which may include an inability to walk and the possibility of months of physical rehabilitation.

"In patients with relapsing disease who are not doing well with steroids, and their deficits are great enough to warrant it, this may not be a bad thing and might allow them to get out of the hospital sooner," Jung said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more on multiple sclerosis.

SOURCES: Vinay Chaudhry, M.D., professor, neurology, Johns Hopkins University School of Medicine, Baltimore; Lily Jung, M.D. medical director, neurology clinic, Swedish Neuroscience Institute, Seattle; Jan. 18, 2011, Neurology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Less invasive techniques help manage complications of severe pancreatic disease
2. Chronic Nasal Congestion May Be Linked to Severe Asthma
3. Cancer Patients Who Smoke Report More Severe Pain
4. Mount Sinai first in US to implant aortic valve prosthesis to treat severe aortic stenosis
5. Obesity increases risk of death in severe vehicle crashes, study shows
6. Nasal congestion can mean severe asthma
7. Severe Pain Can Trigger Suicide in Hospital ERs
8. Severe Bacterial Strain Found in Cystic Fibrosis Patients in Canada
9. Rare, Severe Form of Morning Sickness Appears to Be Genetic
10. Severe Acne May Up Suicide Risk: Study
11. A comparison of severe outcomes during the waves of pandemic (H1N1) 2009
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Some Severe MS Flares Helped by Blood Filtering Treatment 
(Date:2/10/2016)... ... 2016 , ... Intermedix announced on Wednesday that it was ... medicine professional association, to support the organization's newly established physician group with a ... Medicine, or AAEM, seeks to empower emergency physicians to control their own practices. ...
(Date:2/10/2016)... Tarzana, CA (PRWEB) , ... February 10, 2016 ... ... Fernando Valley , announces that his office is now offering a variety of ... cheek enhancement, chin enhancement, eyebrow lift, facial volume restoration, lip enhancement and nasal ...
(Date:2/10/2016)... ... February 10, 2016 , ... Gout is like no other joint pain. ... often severe, with intense swelling and redness. It is triggered by the crystallization of ... adults are the most susceptible, according to the February 2016 issue of Harvard Men's ...
(Date:2/10/2016)... ... ... For additional information contact Phyllis Strupp 480-488-5858 , Brain improves with age, ... Guide to Brain Training" by award-winning author Phyllis Strupp explains how brain ... 16, 2016. A free review copy is available to the media at NetGalley ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... February 26th: Amateur & Professional Divisions - Time: 7:00pm – 10:00pm | ... | Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org , Facebook: http://www.facebook.com/uspolesportsfederation ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... 2016 CSI Specialty Group (CSI) expanded its ... the Specialty Pharmacy Podcast. A free, weekly show, the ... real-world education, discussion and context amongst specialty pharmacy peers ... --> The Specialty Pharmacy Podcast, hosted by ... Group Suzette DiMascio, CHE, CMCE, CPC, is available for ...
(Date:2/10/2016)... , Feb. 10, 2016 Immune Pharmaceuticals Inc. ... announced today that it has filed a patent application ... other cancers. --> --> ... by administration of Ceplene (histamine dihydrochloride) in combination with ... of predicting the efficacy of Ceplene and IL-2 therapy ...
(Date:2/10/2016)...  The ALS Association, in partnership with ALS Finding a ... a biomarker to track TDP43 aggregation. The successful team(s) with ... million investment. --> --> ... cells in the brain and the spinal cord. Eventually, people ... movement, which often leads to total paralysis and death within ...
Breaking Medicine Technology: