Navigation Links
Some Kids Respond Better to ADHD Drug Than Others
Date:10/23/2011

FRIDAY, Oct. 21 (HealthDay News) -- Children with specific gene variants respond better to the drug methylphenidate (Ritalin, Concerta), which is widely used to treat attention-deficit hyperactivity disorder (ADHD), a new study says.

The finding could help improve treatment of ADHD, according to the Cincinnati Children's Hospital Medical Center researchers.

"Physicians don't have a good way of predicting who will experience great improvement in ADHD symptoms with a particular medication, so currently we use a trial-and-error approach. Unfortunately, as a result, finding an effective treatment can take a long time," lead investigator Dr. Tanya Froehlich, a physician in the division of developmental and behavioral pediatrics, said in a medical center news release.

"With more information about genes that may be involved in ADHD medication response, we may be able to predict treatment course, tailor our approach to each child, and improve symptom response while decreasing health care costs," she said.

The researchers tested 89 children aged 7 to 11 with ADHD and found that those with specific variants of the dopamine transporter (DAT) and dopamine receptor D4 (DRD4) genes showed greater improvement in hyperactivity and impulsivity after taking methylphenidate than those without the gene variants.

Specifically, children with the DAT 10-repeat variant and the DRD4 gene 4-repeat showed more response to methylphenidate than those without the variants. A repeat is a short nucleotide coding sequence in a gene that's repeated.

The study was published Oct. 21 in the Journal of the American Academy of Child and Adolescent Psychiatry.

Further research in a larger number of patients is needed to confirm these findings and their clinical significance, the researchers said.

More information

The U.S. National Institute of Mental Health has more about attention deficit hyperactivity disorder.

-- Robert Preidt

SOURCE: Cincinnati Children's Hospital Medical Center, news release, Oct. 17, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. For Valentine's Day, Lifestyle Correspondent and Her Two Sets of Twins Show a Little Love Where Its Needed the Most
2. FriendsofWater.com Responds to the National Acadamy of Sciences Report that Millions of Americans Get Sick Yearly from Contaminated Water
3. American Red Cross Responds Internationally and at Home to Chile Quake
4. AUA Responds to American Cancer Society Guideline for the Early Detection of Prostate Cancer
5. AUA Foundation Responds to American Cancer Society Guideline for the Early Detection of Prostate Cancer
6. Airway Injury Plaguing 9/11 First Responders
7. Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism
8. Tumors may respond to extreme and moderate heat
9. Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism
10. Many WTC Responders Show Signs of Heart Trouble
11. Astellas Responds to OSI Pharmaceuticals Rejection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming and earnest tale ... each of his children. “The Angel” is the creation of published author, Marjorie Lund-Fontaine, ... City, and impassioned writer. , When asked of her new book, Marjorie says, “‘The ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “I Forgive You”: a fine examination ... “I Forgive You” is the creation of published author, Stephen Miller, who, for over ten ... has gracefully given to him. Born in Trinidad and Tobago, he has been serving the ...
(Date:1/20/2017)... ... ... “Christmas in Suffolk”: a story of love, secrets, and mystery. “Christmas ... Indiana where she works in a daycare and looks for inspiration in the local ... Faith Publishing, Sara Seymour’s new book is an adventure of love and secrets. ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a moving and ... God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired truck driver, ... , “I have been writing since high school and have many different titles,” Gaapf ...
(Date:1/20/2017)... ... ... “God's Miracle Man: Against All Odds”: an inspiring affirmation of God’s ... C. A. Tucker, son of Minister Delores Pinnock and a Jamaican native who lives ... , “While sitting up in bed, I felt a pounding headache. It was like ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Jan 20, 2017 Research and Markets ... By Type ([CBC, HGB/HCT, BMP, BUN Creatinine, Electrolyte Testing, HbA1c Testing, ... And Segment Forecasts, 2013 - 2024" report to their offering. ... The global ... by 2024 Introduction of innovative solutions on the grounds ...
(Date:1/20/2017)... 20, 2017  Ethicon Endo-Surgery, Inc. announced ... Products, Inc., a privately held medical device ... tools used in operating rooms worldwide. The ... advanced energy devices with Megadyne,s innovative portfolio ... forward in Ethicon,s goal to deliver the ...
(Date:1/20/2017)... Research and Markets has announced the addition of the ... to their offering. ... This research service on the global pharmaceutical stability testing market ... of the key participants in the market. The ... 2020. The market is expected to grow at a CAGR of ...
Breaking Medicine Technology: