Navigation Links
Some Antibiotics, Blood Pressure Meds a Bad Mix: Study
Date:1/17/2011

hat they interfere with an enzyme in the liver that is needed to break down the calcium channel blocker. When this enzyme is "turned off," too much of the calcium blocker accumulates and causes blood pressure to drop dangerously low, Juurlink explained.

Dr. Barry J. Materson, a professor of medicine at the University of Miami Miller School of Medicine and a specialist in blood pressure, said that this study "is of practical interest."

The researchers have established that the combination of a macrolide antibiotic and a calcium channel blocker can cause hypotension or even shock because of increased blood levels of the calcium channel blocker, Materson said.

"This happens because of the interference with an enzyme that metabolizes the calcium blocker," Materson noted.

Materson added that grapefruit juice can also interfere with the same enzyme and lead to elevated levels of calcium channel blockers. "Grapefruit juice is consumed much more frequently than macrolide antimicrobials," he pointed out.

One limitation of the study is not knowing how many of these patients had hypotension or shock from the infection for which they were receiving the antibiotic. "We also do not know how many, if any, consume grapefruit juice," Materson said.

"Nevertheless, it is important for practitioners, pharmacists and patients to appreciate that both grapefruit juice and macrolide antibiotics, with the possible exception of azithromycin, can increase the blood level of the calcium channel blockers to an unpredictable degree and may rarely result in hypotension or even shock," he said.

More information

For more information on drug interactions, visit the U.S. Food and Drug Administration.

SOURCES: David Juurlink, M.D., Ph.D., scientist, Sunnybrook Research Institute, Toronto; Barry J. Materson, M.D., professor, medicine, Uni
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Smarten Up About Antibiotics, CDC Urges
2. Blood Type O Associated With Less Risk for Heart Attack
3. Bioactive compounds in berries can reduce high blood pressure
4. Room light before bedtime may impact sleep quality, blood pressure and diabetes risk
5. International research team reports major findings in prevention and treatment of blood clots
6. UNC researchers inch closer to unlocking potential of synthetic blood
7. Secondhand Smoke Tied to High Blood Pressure in Kids
8. Embryonic stem cells help deliver good genes in a model of inherited blood disorder
9. Immune Disorders May Raise Blood Clot Risk in Hospitalized Patients
10. Engineering team invents lab-on-a-chip for fast, inexpensive blood tests
11. Early Steps Toward an Alzheimers Blood Test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Some Antibiotics, Blood Pressure Meds a Bad Mix: Study
(Date:12/25/2014)... 25, 2014 Helen Harris’ RP (Retinitis ... Hills, California after an 8 year battle with breast ... Eve evening in her home in Woodland Hills California ... cancer. , As the founder and ... she pioneered and championed many of today's greatest breakthroughs ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 (HealthDay ... receive effective, less expensive care from a clinic that functions ... of dedicated health care professionals, a new study shows. ... either hospitalization or a trip to the emergency room when ... the University of Texas in Houston versus usual care, according ...
(Date:12/25/2014)... WEDNESDAY, Dec. 24, 2014 (HealthDay News) -- Among early ... treatment, less than half of one percent will eventually ... new analysis reveals. The finding comes from a ... between 1998 and 2007, and it suggests that the ... double what experts had previously thought. "The frequency ...
(Date:12/25/2014)... New York (PRWEB) December 25, 2014 ... continue to move forward in a number of multidistrict ... of West Virginia, Bernstein Liebhard LLP reports. According to ... is scheduled to convene a Joint Status Conference in ... 10:00 a.m. Parties have been directed to submit a ...
(Date:12/25/2014)... Newton, North Carolina (PRWEB) December 25, 2014 ... a North Carolina Retirement Community, recently showed their ... and girls of the Catawba County Parenting Network- ... meal, the 10 children gathered around the largest ... community to open presents purchased by residents of ...
Breaking Medicine News(10 mins):Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Retirement Community Residents Make Impact During Holiday Season 2
... are estimated to already have bone diseases, and almost ... mass, putting them at increased risk for osteoporosis, according ... professor of mechanical engineering at the University of Delaware, ... Wang,s aunts have suffered from the insidious bone-thinning disease, ...
... do you do when a naturally occurring hormone in your ... that same hormone melatonin is a popular supplement ... Houston professor and his team of researchers may have some ... the department of biology and biochemistry at UH, describes his ...
... colonography (CTC), when used in elderly patients, can detect ... the colon (including cirrhosis and tumors) and is well ... at St. Jamess University Hospital in Leeds, United Kingdom ... (over age 70) with lower gastrointestinal tract symptoms, who ...
... Services,International Inc. (Pink Sheets: MSITF) is pleased to announce ... obtained by regulatory,agencies related to the VScan HIV and ... that detects HIV and TB simultaneously has increased,substantially. ... It is very difficult to,get individuals to make themselves ...
... Raise Radon Awareness, HARRISBURG, Pa., Nov. 15 ... after winning the state,s,radon poster contest, which is ... "I congratulate these students on their creativity ... and I urge everyone to have their homes ...
... Hunger, CHICAGO, Nov. 15 In Florida, 16 percent ... do not,always know where they will find their next meal. ... children in small towns,and big cities lives in a food ... 12 million children in the United,States live in this condition ...
Cached Medicine News:Health News:Bad to the bone: UD research to shed light on osteoporosis 2Health News:Bad to the bone: UD research to shed light on osteoporosis 3Health News:The hormone of darkness: melatonin could hurt memory formation at night 2Health News:The hormone of darkness: melatonin could hurt memory formation at night 3Health News:CT colonography detects wide-range of extracolonic abnormalities in elderly patients 2Health News:Medical Services Gets Significant Interest in Its Dual VScan Test Kit 2Health News:PA DEP Secretary Announces Pennsylvania's Radon Poster Contest Winners 2Health News:New Report Finds 16 Percent of All Children in Florida Don't Have Consistent Access to Meals 2Health News:New Report Finds 16 Percent of All Children in Florida Don't Have Consistent Access to Meals 3Health News:New Report Finds 16 Percent of All Children in Florida Don't Have Consistent Access to Meals 4Health News:New Report Finds 16 Percent of All Children in Florida Don't Have Consistent Access to Meals 5
(Date:12/24/2014)... SAN DIEGO , Dec. 23, 2014 ResMed ... a significant patent infringement action against Chinese medical device manufacturer ... Commission (ITC) ruled today that BMC,s masks listed below infringe ... advertising, or selling these masks in the United ... , iVolve N2 nasal mask , Willow nasal pillows ...
(Date:12/24/2014)... -- Lockton Dunning Benefits, the Dallas ... of Vice President Kim Foerster on ... team, Excelsior Solutions. Foerster brings ... position.  Most recently, she worked as the Director ... where she has held various managerial positions since ...
(Date:12/24/2014)... and RALEIGH, N.C. , ... of Endo International plc (NASDAQ: ENDP ) ... BDSI ) announced today that they have submitted ... Film to the U.S. Food and Drug Administration (FDA).  ... management of pain severe enough to require daily, around-the-clock, ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Kim Foerster Joins Lockton Companies 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: