Navigation Links
SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
Date:4/11/2012

Boulder, CO April 11, 2012 -- In a scientific paper published today in the journal PLoS ONE, researchers from SomaLogic and the University of Washington in Seattle describe the first application of the SOMAscanTM proteomic assay technology to tissue samples. Working with both tumor and non-cancerous lung samples from patients with non-small cell lung cancer (NSCLC), they identified significant expression changes in 36 proteins, including 13 proteins not previously associated with the disease. These findings reveal significant new information about the biology underlying NSCLC, and have implications for improving early diagnosis and treatment.

"Early detection of NSCLC can dramatically improve the prognosis for patients with the disease, as has been shown recently through the use of CT-scans in a high-risk population of heavy smokers," said Sheri Wilcox, Ph.D., Director of Discovery Sciences at SomaLogic. "However, this approach has a high false-positive rate, which can result in overdiagnosis and unnecessary treatment. We set out to find additional molecular 'biomarkers' that would help guide both the use of imaging techniques as well as choosing appropriate treatments."

In their study, the researchers found 36 protein biomarkers that showed significant expression differences between the tumor tissue and non-cancerous lung tissue samples taken from the same patients. These potential biomarkers were discovered by simultaneously measuring the expression levels of 820 different proteins in all samples examined, using SomaLogic's SOMAscan proteomic assay. Of these 36 potential biomarkers, thirteen had not previously been associated with NSCLC, providing new biological insights into the disease as well as suggesting potential new therapeutic targets.

In addition to the NSCLC protein biomarker discovery, the scientists also demonstrate the utility of the protein-binding reagents used in SOMAscan for direct visualization of protein expression in tissue sections using standard histopathology techniques. SOMAmer (Slow Off-rate Modified Aptamer) binding reagents bind their respective proteins in a manner similar toand as effective asantibodies, but unlike antibodies they can be used in highly multiplexed applications to look at expression differences across thousands of proteins in a single experiment. And as demonstrated in the PLoS ONE paper, SOMAmers can also be used as individual tissue probing agents for pathology studies.


'/>"/>

Contact: Fintan R. Steele, Ph.D.
fsteele@somalogic.com
720-214-3080
SomaLogic, Inc.
Source:Eurekalert

Related medicine news :

1. NEJM Publishes Trial Results Demonstrating Bard FLAIR Endovascular Stent Graft Is Superior To Balloon Angioplasty For Failing Dialysis Grafts
2. Cancer publishes study confirming disparity in breast cancer treatment
3. Board Certified Renal Specialist, Nina Kolbe, Publishes Second Edition of Kidney Health Gourmet: A Diet Guide and Kidney Friendly Recipes for People Not on Dialysis
4. kajeet Publishes Free Guidelines for Teen and Tween Cell Phone Use
5. Stonebranch Publishes Healthcare IT White Paper
6. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
7. EHRtv.com Publishes Over 40 Video Interviews from HIMSS10
8. Dental Practice Marketing Specialist Publishes 1st Article for LIVESTRONG.COM
9. ATS publishes joint statement on renal failure in the ICU patient
10. Questia Online Library Publishes Top Research Topics of 2010 Spring Semester
11. Better Hearing Institute Publishes Comprehensive Consumer Guide to Buying Hearing Aids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... ... March 27, 2017 , ... Mt. Angel Vitamins, a 5-year-old ... rebranding effort. This includes the introduction of new packaging and messaging, as well ... we learned that a simple, proactive approach to wellness is important to vitamin ...
(Date:3/27/2017)... RICHEY, Fla. (PRWEB) , ... March 27, 2017 ... ... drug overdose deaths soared 167%,(1) with opioids alone responsible for over 33,000 of ... Kevin McCarty has sponsored Assembly Bill (AB) 1512, which proposes a tax on ...
(Date:3/26/2017)... Ohio (PRWEB) , ... March 26, 2017 , ... ... doctors worldwide to receive the RealSelf 100 Award, a prestigious award honoring the ... cosmetic procedures and to find and connect with doctors and clinics. , In ...
(Date:3/24/2017)... ... 2017 , ... Clean Earth, Inc., a leader in providing ... materials announced today the acquisition of privately owned AERC Recycling Solutions ... facilities and a vast array of additional technologies, services, and new markets to ...
(Date:3/24/2017)... ... 24, 2017 , ... Infectious disease affects billions of people ... States, it’s a threat that is constantly changing and evolving. Mediaplanet's “Fighting Infection” ... strategies for the healthcare community to help decrease the number of completely preventable ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... -- Twist Bioscience, a company accelerating science and innovation through ... an additional $33 million. To date, Twist Bioscience has ... "It is an exciting time to be leading Twist ... deliver industry-leading gene volume to our customers, enabling innovative ... Ph.D., CEO of Twist Bioscience. "We welcome the additional ...
(Date:3/27/2017)... Texas , March 27, 2017   Genprex, Inc. , ... that Julien Pham , MD, the Company,s Chief Operating Officer, ... investor conferences. Sachs 5th Annual Cancer BioPartnering & ... New York, NY ... BioCentury 24th Annual Future Leaders in ...
(Date:3/24/2017)... PORTLAND, Oregon and PUNE, India , March 24, 2017 ... in 2015, and is estimated to reach $2,614 million by 2022, Globally, registering a ... expected to generate the highest revenue, and is projected to dominate the market during ... ... Allied Market Research Logo ...
Breaking Medicine Technology: