Navigation Links
Solving mystery of how sulfa drugs kill bacteria yields 21st century drug development target
Date:3/1/2012

MEMPHIS, Tenn. -- More than 70 years after the first sulfa drugs helped to revolutionize medical care and save millions of lives, St. Jude Children's Research Hospital scientists have determined at an atomic level the mechanism these medications use to kill bacteria. The discovery provides the basis for a new generation of antibiotics that would likely be harder for bacteria to resist and cause fewer side effects.

The work focused on sulfa drugs and their target enzyme, dihydropteroate synthase (DHPS). Most disease-causing microorganisms need DHPS to help make the molecule folate, which is required for the production of DNA and some amino acids. Working with enzymes from gram-negative and gram-positive bacteria, researchers used a variety of techniques to determine for the first time the key intermediate structure DHPS forms during the chemical reaction to advance folate production. The structure also explains at a molecular level how sulfa drugs function and how resistance causing mutations help bacteria withstand them.

The findings mark a major advance in both microbial biochemistry and anti-microbial drug discovery. The study is published in the March 2 issue of the journal Science.

"The structure we found was totally unexpected and really opens the door for us and others to design a new class of inhibitors targeting DHPS that will help us avoid side effects and other problems associated with sulfa drugs," said Stephen White, Ph.D., chair of the St. Jude Department of Structural Biology and the paper's corresponding author.

Co-author Richard Lee, Ph.D., a member of the St. Jude Department of Chemical Biology and Therapeutics, added: "Now we want to leverage this information to develop drugs against the opportunistic infections that threaten so many St. Jude patients."

Sulfa drugs were discovered in the 1930s and became the first antibiotic in widespread use. Although the drugs were early victims of antib
'/>"/>

Contact: Carrie Strehlau
media@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Experts Optimistic About Solving Puzzle of Alzheimers
2. Work Teams Who Share Negative Emotions Better at Problem-Solving
3. IOM and NAE launch collegiate challenge aimed at solving health problems
4. ISU research raises hope for solving Parkinsons disease puzzle
5. Solving a traditional Chinese medicine mystery
6. Presumed consent not answer to solving organ shortage in US, researchers say
7. Contact Dermatitis Can Be Irritating, Especially When the Cause is a Mystery
8. Scientist, Dr Staninger, Unlocks the Mystery of Morgellons Disease
9. U of T researchers crack splicing code, solve a mystery underlying biological complexity
10. Parkinsons Transplant Mystery Solved, Researchers Say
11. Is Frequency the Future of Medicine or an Ancient Mystery Revealed?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... scientists could lead to potential new treatments for breaking ... , Fibrosis, or scarring, is a hallmark of ... lungs can lead to serious organ damage and, in ... options centers on findings made by Swati Bhattacharyya, PhD, ... that a specific protein plays in promoting fibrosis. ...
(Date:4/17/2014)... Ill. One of the most popular vaccine brands ... And doctors may be overlooking some cost factors when ... a more expensive option, according to a new study ... vaccines to administer can be driven by numerous factors," ... and a professor of computer science and of mathematics ...
(Date:4/17/2014)... In a review published in the April issue of ... The Feinstein Institute for Medical Research, says it,s time ... approach to treating sepsis, which kills millions ... Sepsis occurs when molecules released into the bloodstream to ... body. Inflammation is necessary for maintaining good health ...
(Date:4/17/2014)... older Americans suffer from depression, often brought on by ... a project that followed the lives of thousands ... that Internet use among the elderly can reduce the ... "That,s a very strong effect," said Shelia Cotten, a ... media who led the project. "And it all has ...
(Date:4/17/2014)... April 17, 2014 EcoHealth Alliance, a nonprofit organization ... published a comprehensive review today examining the current state ... The review calls for improved global surveillance strategies to ... recent outbreak of Ebola in West Africa that has ... of Guinea and Liberia. According to the World ...
Breaking Medicine News(10 mins):Health News:New clues on tissue scarring in scleroderma 2Health News:Study recalculates costs of combination vaccines 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Internet use can help ward off depression among elderly 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3
... 23, 2009) Postpartum depression is a seriousand often ... mothers. Some of the causes might include personal history ... financial or emotional support. Left untreated, it can have ... on her child,s development. , In the ...
... suggest that men discuss use of medicines such as Propecia ... Healthy men with no signs of prostate cancer may wish ... could further reduce their risk for the disease, new guidelines ... the American Urological Association have issued new guidelines recommending that ...
... Medical Center treated its first behavioral health patient yesterday with ... is the first DoD facility to use this technology and ... others such as Brown University , Columbia University ... TMS Therapy device was approved by the FDA last October ...
... , What A Congressional forum organized by the Leadership Conference ... last two decades more than a half, ... healthcare coverage. Critical analysis of these models is ... reform debate. The February 25 forum, ...
... their jobs and health insurance, they,re turning to federal ... 24 (HealthDay News) -- Although millions of Americans have ... during the current recession, health care spending in the ... increase in 2009. , That,s the surprising conclusion of ...
... TO SEE INFLUENZA AS A CREDIBLE BUSINESS THREATDETROIT, Feb. ... lost wages every year, and recent studies found that ... about 200 million days of restricted activity, are due ... low, especially among working adults. In fact, adults between ...
Cached Medicine News:Health News:Diabetes a risk factor for postpartum depression 2Health News:Drugs May Help Healthy Men Lower Prostate Cancer Risk 2Health News:Walter Reed First Military Hospital to Use Transcranial Magnetic Stimulation to Treat Depression 2Health News:National Lessons from State Health Reform: The Massachusetts Case Study 2Health News:Recession Scrambling Health Spending in U.S. 2Health News:Recession Scrambling Health Spending in U.S. 3Health News:Recession Scrambling Health Spending in U.S. 4Health News:Influenza Infection Costs Employees Billions Each Year; Working Adults Largest Group Not Immunized Annually 2Health News:Influenza Infection Costs Employees Billions Each Year; Working Adults Largest Group Not Immunized Annually 3Health News:Influenza Infection Costs Employees Billions Each Year; Working Adults Largest Group Not Immunized Annually 4
(Date:1/15/2014)... 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ECTE ... CGM System as a non-invasive, wireless continuous glucose monitoring ... Executive Chairman and Interim CEO of Echo Therapeutics, will ... Equity Conference. Mr. Doman will make ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Worldwide Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Drug Delivery Systems -- Focus on End ... STUDY OBJECTIVES A drug ...
Breaking Medicine Technology:Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
... BRUNSWICK, N.J., Nov. 28, 2011  Johnson & Johnson (NYSE: ... Annual Health Care Conference on Tuesday, Nov. 29 th at ... Chairman, Ethicon will present in a session scheduled at 8:00 a.m. ... investors and other interested parties by accessing the Johnson & Johnson ...
... 2011 The National Association of Drug Diversion ... cooperation between law enforcement, healthcare professionals, state regulatory ... investigation of drug diversion – today applauded the ... Exchange (NPLEx) demonstrating the real-time, stop-sale system in ...
Cached Medicine Technology:Alabama Stop-Sale System Blocks Illegal Sales & Allows Legal Ones 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: