Navigation Links
Solid tumor cells not killed by radiation and chemotherapy become stronger
Date:6/9/2008

tumors. In fact, however, oxygen levels cycle up and down virtually everywhere in the tumor, which is caused by fluctuations in blood flow rate. It has been a challenge to convince people of this."

Dewhirst and colleagues have made movies of oxygen transport in a tumor of a living animal that show the oxygen levels cycle up and down significantly, pulsing in waves seen as color changes in the movies. (View these movies at the Nature Reviews Cancer site: http://www.nature.com/nrc/journal/v8/n6/suppinfo/nrc2397.html )

The Duke team argues that blocking HIF1 is the consistent answer to tumor growth problems. Blocking HIF1 activity interferes with the tumor's ability to undergo glycolysis (energy production) in low-oxygen conditions, which blocks tumor growth, the authors wrote. Exactly how to accomplish chemotherapy or radiation treatment in the safest, most effective ways, in combination with HIF1 blockade, is still open for exploration, Dewhirst said.

For example, targeting HIF1 in the early stages of tumor growth, especially in very early cancer spread, may help, Dewhirst said. "For a woman who has had a primary breast tumor removed, and who is at high risk for cancer spread, this might be a situation in which you'd target HIF1," he explained. "Blocking HIF1 makes sense during the early stages of angiogenesis, which is the accelerated phase of blood vessel formation. In this way, you could keep the early metastasis sites inactive and prevent them from growing."

The Duke team has completed a phase I trial with a HIF1 inhibitor. "We are actively pursuing this clinically and will be moving this study into Phase 2," Dewhirst said. "We are interested in other applications of HIF-1 inhibition in combination with radiation and chemotherapy for different diseases."


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. MedAmerica Reports Solid Growth, Outperforms Industry
2. Insurance Department to Hold Statewide Meetings on Proposed Consolidation of Independence Blue Cross, Highmark
3. STAAR Surgical Reports Solid First Quarter Progress
4. Life Sciences Discovery Fund Awards $2.2 Million to Support New Solid-Tumor Research Program
5. A long-term survival offered by resection of solid-pseudopapillary tumor of the pancreas?
6. New target for cancer therapy may improve treatment for solid tumors
7. Novo Nordisk Consolidates U.S. Diabetes Sales Leadership Under Single Vice President
8. Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007
9. SAFC Pharma Expands Its Pharmorphix Solid State Chemistry Services
10. Insurance Department Will Hold Public Hearings on Proposed Consolidation of Highmark, Independence Blue Cross
11. James E. Harris to Become Chief Financial Officer of Coca-Cola Bottling Co. Consolidated
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... Richmond, Virginia (PRWEB) May 25, 2013 ... bracelet that relieves pain in seconds for arthritis, tendinitis ... innovator in alternative pain relief products announced a ... seconds. The magnetic bracelet for pain relief is demonstrated ... for pain uses 5400 Gauss magnets and has customers ...
(Date:5/25/2013)... CA (PRWEB) May 25, 2013 ... news of a judge's overturning of a jury's award ... in the first trial* in the country over allegations ... according to court files. , The judge in the ... evidence to show his cancer was caused by the ...
(Date:5/24/2013)... May 25, 2013 The special 35% ... ® products from Sublime Beauty®. The products include ... cellulite, and many of the ingredients are in fact ... and is dreaded by many women," says Kathy Heshelow, ... plan, women can diminish their cellulite." The plan includes ...
(Date:5/24/2013)... Part guidebook, part memoir, Peter Amato, M.A., ... true approach to meditation for the recovery community. Entitled ... Step, the book outlines a comprehensive method for recovering ... step in any 12-step recovery programs such as Alcoholics ... ever-growing global health problem affecting the physical and psychological ...
(Date:5/24/2013)... Compromise is often cited as crucial for relationships, though no ... comfort. However, many couples find themselves facing dilemmas as mattress ... cause added stress, lost sleep, and some resentment. What’s The ... in their latest article on the subject. , The ... do When You Disagree on the Best Mattress ”, takes ...
Breaking Medicine News(10 mins):Health News:Magnetic bracelet relieves pain in seconds announces Superior Magnetics 2Health News:Alleged Actos Bladder Cancer Lawsuits Update: $6.5 Million Verdict Overturned as Resource4thePeople Attorneys Continue to Accept Cases 2Health News:Alleged Actos Bladder Cancer Lawsuits Update: $6.5 Million Verdict Overturned as Resource4thePeople Attorneys Continue to Accept Cases 3Health News:Alleged Actos Bladder Cancer Lawsuits Update: $6.5 Million Verdict Overturned as Resource4thePeople Attorneys Continue to Accept Cases 4Health News:"Get Ready for Summer Sale" at Sublime Beauty® Continues: New Cellulite Whisperer® Products 2Health News:Guidebook for Recovery Published by Meditation Master Peter Amato 2Health News:Guidebook for Recovery Published by Meditation Master Peter Amato 3Health News:What’s The Best Bed Offers Mattress & Sleep Solutions for Opposite Couples 2
... ... the opening of a new technology solutions office in Ahwatukee to better serve clients in ... business IT and Phoenix computer repair services or free website hosting for 2010 to new ... (PRWEB) May 27, ...
... ... existing lineup of Keetsa Mattresses and Ecomfort Products. The Online Retailer continues to add ... on their sleep at Discount Prices. , ... Houston, TX (PRWEB) May 27, 2010 -- Home and Bedroom has just added ...
... ... year has had a fantastic first year with over 30,000 registrations. A key reason ... mums and mums-to-be via freephone, livechat or email. , ... (PRWEB) May 27, 2010 -- Over 30,000 mums-to-be and new mums ...
... ... show 69 percent of people between the ages of 35 to 44 have ... permanent teeth by the age of 74. With permanent tooth replacement treatments such ... is using a unique incentive for patients who don’t want the hassle of ...
... ... a greater degree of reliability and authenticity to a now-thriving industry, the ... a group of network marketing companies (List of Recipients attached) selected from ... annual industry certification program to compile the best network marketing opportunities available. ...
... ... crack down on sewer overflows that cause untreated sewage to flow ... of major municipal wastewater systems. Rather than building bigger systems to ... combine traditional civil engineering practices with state-of-the-art concepts from the aerospace ...
Cached Medicine News:Health News:my PC Techs Opens New Technology Solutions Office in Ahwatukee 2Health News:Home and Bedroom Adds Simmons Beautyrest Mattresses to Help Customers Sleep Well 2Health News:New Australian Pregnancy and Baby Club Exceeds all Expectations in First Year 2Health News:As Popularity of Dental Implants Rise, a Chicago Cosmetic Dentistry Practice's On-site Lab Offers Patients a Unique Incentive 2Health News:As Popularity of Dental Implants Rise, a Chicago Cosmetic Dentistry Practice's On-site Lab Offers Patients a Unique Incentive 3Health News:Direct Selling Reps' Association Announces 2010 Certificate Of Excellence Recipients 2Health News:Direct Selling Reps' Association Announces 2010 Certificate Of Excellence Recipients 3Health News:OHM Cheers End of the "Build it Bigger" Directive: Metropolitan Communities Look to New Methods to Evaluate, Rehabilitate Aging Sewer Systems 2Health News:OHM Cheers End of the "Build it Bigger" Directive: Metropolitan Communities Look to New Methods to Evaluate, Rehabilitate Aging Sewer Systems 3Health News:OHM Cheers End of the "Build it Bigger" Directive: Metropolitan Communities Look to New Methods to Evaluate, Rehabilitate Aging Sewer Systems 4
(Date:5/23/2013)... , May 23, 2013 Anthem Blue ... that would have required them to obtain their medications ... Consumer Watchdog and Whatley Kallas LLC.  ... Court, alleged that Blue Cross,s mandatory mail order program ... their health and privacy. "This settlement brings ...
(Date:5/23/2013)... 2013  Hologic, Inc. (Hologic or the Company) ... manufacturer and supplier of premium diagnostics, medical imaging ... serving the healthcare needs of women, today announced ... U.S. clinical practice comparing breast cancer screening with ... 2D mammography alone showed a significant reduction in ...
(Date:5/23/2013)...  Ameritox, the nation,s leader in pain medication ... to become part of its Urine Drug Monitoring ... and improve the clinical outcomes for injured workers. ... manager in the workers, compensation industry, has used ... management strategy for several years. By establishing a ...
Breaking Medicine Technology:Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 2Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 2Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 3
... 8, 2010 George Products Company, Inc. has announced ... of its OASIS Inspection Systems. Florida ... southeast Florida. OASIS Inspection Systems is a line of ... to quality control departments across the United States. Tim ...
... 1st to the 3rd of March 2011, vaccine leaders ... World Summit in New Delhi. The event will be ... Vaccine Manufacturers Network). Participants will be discussing ... pandemic surveillance programs, low cost and fast vaccine manufacturing ...
Cached Medicine Technology:Florida Metrology To Distribute OASIS Inspection Systems 2World Vaccine Leaders to Meet in New Delhi India to Tackle Global Public Health Challenges 2
Hydrophobic PE filter without self-sealing additives, permits sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human ...
... Finntip Filters are ideal ... methods, or for any work ... They are designed for pipetting ... samples, and other. For applications ...
... ART Aerosol Resistant Tips offer a safe ... Tips are designed for applications such as ... In addition, ART Tips are excellent for ... forensic studies. ART Tips prevent aerosol contaminants ...
200 L, Racked, Filtered, Pre-sterilized, 96 tips/rack Recommended for 20, 25, 50, 100 and 200 L pipettes. Can also be used with 300 L pipettes when pipetting 200 L or less....
Medicine Products: