Navigation Links
Software toolkit shapes models for personalized radionuclide therapy
Date:6/11/2013

Vancouver, British Columbia External beam radiation treatment has long been manipulated into the unique shape of patients' tumors for personalized cancer care. Technology providing a means of patient-specific radionuclide drug therapies has not been standardized, as it has been limited to software that requires oncologists to manually define the areas of tumors. A new "phantom" model of the human form that can be deformed and reformed to match anatomy in a matter of hours using 3D graphic design software is being combined with a precision method for predicting how radionuclide therapies interact with tissues to determine the most effective cancer-killing dose for every patient.

"One-size-fits all therapy is not optimal for patients who could be getting personalized cancer treatment," said Susan Kost, MS, principal author of the study from Vanderbilt University in Nashville, Tenn. "With individualized patient modeling we have an opportunity to offer more aggressive radionuclide therapy. Knowing a patient's drug kinetics and anatomy means we can give the maximum dose possible while minimizing effects on normal tissue."

The geometric design technology used for these anthropomorphic models, created by Paul Segars, PhD, at Duke University, is called NURBS (non-uniform rational b-splines). With NURBS, anatomical volumes derived from computed tomography imaging data of patients' organs and body parts are sculpted, rotated and scaled to create a model within one to two hours. Once a model is made, it is used for treatment planning in conjunction with single photon emission computed tomography or positron emission tomography, whichin most casesuse non-therapeutic imaging agents to mimic therapeutic radioactivity in the body. This allows physicians to extrapolate a precise dose, a process called dosimetry, via a 3D map representing projected dose absorption.

Ordinarily, dosimetry is performed by defining the structure and volume of tumors manually in 3D computer programs, known as tumor segmentation. However, this method can be labor intensive and may not provide dose information for normal tissue. In this study, patient-specific NURBS models serve as input in automated dosimetry calculations to factor anatomical data and radiopharmaceutical kinetics for I-131 radioimmunotherapy, specifically looking at the distribution of radioactive particles in the body as they seek out physiological processes of cancer cells and tissues. In action, tumor-tailored monoclonal antibodies are labeled with a potent dose of a radioisotope, and together they bind to receptors on the surface of cancer cells, effectively killing them and sparing nearby healthy cells.

"This research brings nuclear medicine therapy alongside external beam radiation therapy," Kost added. "Now each patient can receive his or her own therapy plan, leading to improved outcomes, better survival rates and less toxicity and harm to normal tissue in the body."

The NURBS phantom models are currently available for clinical use, and Kost expects the modeling toolkit to be used in a subsequent clinical trial conducted by Vanderbilt University for a tumor-targeted peptide receptor radionuclide therapy. A commercially viable version of the dosimetry software is scheduled for release to other cancer centers starting sometime next year.


'/>"/>

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Lung nodule matching software dramatically increases radiologists efficiency
2. MTSS-mba Membership Benefits Administration Software for Private and Taft-Hartley Employee Benefit Funds Releases New Pension Modules
3. New software helps reveal patterns in space and time
4. Scientists decode software instructions of aggressive leukemia cells
5. Cambridge software improves quality of sound for hearing aid users
6. PVI Solar Installs The Largest Solar Powered Sign In The U.S. For A St. Petersburg, Florida Based Software Firm, Clairfire
7. Evident Dental Laboratory Management Software Prepares US Dental Labs for New Medical Devices Tax Starting January 1st, 2013
8. GLOBODOX (Enterprise Document Management Software) Launches Contest for Legal Experts to Define Technology Challenges Expected in 2013
9. UH Case Medical Center & Reach Ventures form Socrates Analytics to market hospital data software
10. Tennessee Dental Association and Succeed Management Solutions Partner to Deliver New Safety Software Solution for Tennessee Dentists
11. EzW2 Software From Halfpricesoft.com Updated To Accelerate Tax Reporting For Startups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... ... and relationship-marketing firm, announced today that nominations will be accepted from December ... (ISE®) Central Awards. , Awards include the Information Security Executive® of the ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... Meeting through tomorrow, December 6th, sparks a conversation about epilepsy, bearing down on ... in 26 people will be diagnosed with epilepsy within their lifetime. With such ...
(Date:12/5/2016)... , ... December 05, 2016 ... ... interoperability, today announced that the company will provide alerting technology to Central ... been recently awarded $1.7 million in federal funds as the sole sub-recipient ...
(Date:12/5/2016)... ... December 05, 2016 , ... Dr. Barry M. Weintraub, one ... Surgery, who recently participated in the 36th Annual Cutting Edge Aesthetic Symposium at the ... techniques for getting that perfect, yet natural-looking, nose. Dr. Weintraub, who is world-renowned for ...
(Date:12/5/2016)... , ... December 05, 2016 , ... ... Officer for the Florida Hospital West Florida Region. McGuinness brings experience in executive ... and engaging staff, physicians and leaders. , In her new role, that officially ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016  BD (Becton, Dickinson ... global medical technology company, will demonstrate an enhanced technology ... management technologies, including the company,s leading Pyxis™ and Alaris™ ... Pharmacists (ASHP) 2016 Midyear Meeting being held in ... While national data show that approximately 68 ...
(Date:12/5/2016)... Research and Markets has announced the addition of the "Global ... and Demand Forecast to 2022" report to their offering. ... , , ... market is expected to grow at a CAGR of 4.5% during ... witnessing high growth, due to growing female geriatric population and increasing ...
(Date:12/5/2016)... England , December 5, 2016 ... Transitions to Deputy Chairman   ... on selectively targeting deubiquitylating enzymes (DUBs) to treat cancer, neurodegenerative ... has been appointed as non-executive Chairman, effective January 1 st ... of Mission Therapeutics as a non-executive Director in July 2015. ...
Breaking Medicine Technology: