Navigation Links
Software toolkit shapes models for personalized radionuclide therapy
Date:6/11/2013

Vancouver, British Columbia External beam radiation treatment has long been manipulated into the unique shape of patients' tumors for personalized cancer care. Technology providing a means of patient-specific radionuclide drug therapies has not been standardized, as it has been limited to software that requires oncologists to manually define the areas of tumors. A new "phantom" model of the human form that can be deformed and reformed to match anatomy in a matter of hours using 3D graphic design software is being combined with a precision method for predicting how radionuclide therapies interact with tissues to determine the most effective cancer-killing dose for every patient.

"One-size-fits all therapy is not optimal for patients who could be getting personalized cancer treatment," said Susan Kost, MS, principal author of the study from Vanderbilt University in Nashville, Tenn. "With individualized patient modeling we have an opportunity to offer more aggressive radionuclide therapy. Knowing a patient's drug kinetics and anatomy means we can give the maximum dose possible while minimizing effects on normal tissue."

The geometric design technology used for these anthropomorphic models, created by Paul Segars, PhD, at Duke University, is called NURBS (non-uniform rational b-splines). With NURBS, anatomical volumes derived from computed tomography imaging data of patients' organs and body parts are sculpted, rotated and scaled to create a model within one to two hours. Once a model is made, it is used for treatment planning in conjunction with single photon emission computed tomography or positron emission tomography, whichin most casesuse non-therapeutic imaging agents to mimic therapeutic radioactivity in the body. This allows physicians to extrapolate a precise dose, a process called dosimetry, via a 3D map representing projected dose absorption.

Ordinarily, dosimetry is performed by defining the structure and volume of tumors manually in 3D computer programs, known as tumor segmentation. However, this method can be labor intensive and may not provide dose information for normal tissue. In this study, patient-specific NURBS models serve as input in automated dosimetry calculations to factor anatomical data and radiopharmaceutical kinetics for I-131 radioimmunotherapy, specifically looking at the distribution of radioactive particles in the body as they seek out physiological processes of cancer cells and tissues. In action, tumor-tailored monoclonal antibodies are labeled with a potent dose of a radioisotope, and together they bind to receptors on the surface of cancer cells, effectively killing them and sparing nearby healthy cells.

"This research brings nuclear medicine therapy alongside external beam radiation therapy," Kost added. "Now each patient can receive his or her own therapy plan, leading to improved outcomes, better survival rates and less toxicity and harm to normal tissue in the body."

The NURBS phantom models are currently available for clinical use, and Kost expects the modeling toolkit to be used in a subsequent clinical trial conducted by Vanderbilt University for a tumor-targeted peptide receptor radionuclide therapy. A commercially viable version of the dosimetry software is scheduled for release to other cancer centers starting sometime next year.


'/>"/>

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Lung nodule matching software dramatically increases radiologists efficiency
2. MTSS-mba Membership Benefits Administration Software for Private and Taft-Hartley Employee Benefit Funds Releases New Pension Modules
3. New software helps reveal patterns in space and time
4. Scientists decode software instructions of aggressive leukemia cells
5. Cambridge software improves quality of sound for hearing aid users
6. PVI Solar Installs The Largest Solar Powered Sign In The U.S. For A St. Petersburg, Florida Based Software Firm, Clairfire
7. Evident Dental Laboratory Management Software Prepares US Dental Labs for New Medical Devices Tax Starting January 1st, 2013
8. GLOBODOX (Enterprise Document Management Software) Launches Contest for Legal Experts to Define Technology Challenges Expected in 2013
9. UH Case Medical Center & Reach Ventures form Socrates Analytics to market hospital data software
10. Tennessee Dental Association and Succeed Management Solutions Partner to Deliver New Safety Software Solution for Tennessee Dentists
11. EzW2 Software From Halfpricesoft.com Updated To Accelerate Tax Reporting For Startups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2017)... Aliso Viejo, California (PRWEB) , ... January 15, 2017 , ... ... create a stylistic slideshow with complete customization and ease," said Christina Austin - CEO ... variety of controls so that users can edit the style and animation of their ...
(Date:1/15/2017)... ... January 15, 2017 , ... The JPR ... pleased to announce that it will be assisting HackensackUMC Mountainside with its public ... Ridge townships, servicing all surrounding towns. The firm will be working closely with ...
(Date:1/14/2017)... ... ... Volume 3 is a self animating masking transition which allows users to reveal any object ... Austin - CEO of Pixel Film Studios. , TransFreeze Volume 3 provides FCPX ... the next. , To use “Cut-Out First” presets, choose a video clip and ...
(Date:1/13/2017)... , ... January 13, 2017 , ... KOAMTAC ®, ... will be showcasing the next generation companion scanner and data collector at the National ... KDC270 has been created as an answer to the market’s need for more compact ...
(Date:1/13/2017)... ... January 13, 2017 , ... People who have sensitive teeth are about as ... brush their teeth. Sadly, most dental hygiene products in the market contain chemical ingredients ... these people, continuing their daily oral care routine to keep their teeth white and ...
Breaking Medicine News(10 mins):
(Date:1/14/2017)... , Jan. 14, 2017  Johnson & Weaver, LLP ... of purchasers of Zimmer Biomet Holdings, Inc. (NYSE: ... through October 31, 2016 (the "Class Period"). Zimmer ... and markets orthopaedic reconstructive products, such as knee and hip ... ...
(Date:1/13/2017)... , January 13, 2017 Constant research ... AIDS will collectively contribute to the demand for western blotting ... a value of US$ 551.0 Mn by 2016 end. Developing ... the most lucrative markets for western blotting, whereas ... globally. ...
(Date:1/13/2017)... YORK , January 13, 2017 ... equities to see how they have fared at yesterday,s ... ), Galena Biopharma Inc. (NASDAQ: GALE ), ... These companies harness cellular and biomolecular processes to develop ... reduce our environmental footprint, feed the hungry, use less ...
Breaking Medicine Technology: