Navigation Links
Software for analyzing digital pathology images proving its usefulness

As tissue slides are more routinely digitized to aid interpretation, a software program whose design was led by the University of Michigan Health System is proving its utility.

In a new study, a program known as Spatially Invariant Vector Quantization (SIVQ) was able to separate malignancy from background tissue in digital slides of micropapillary urothelial carcinoma, a type of bladder cancer whose features can vary widely from case to case and that presents diagnostic challenges even for experts.

The findings by U-M and Rutgers University researchers were published online in Analytical Cellular Pathology ahead of print publication.

"Being able to pick out cancer from background tissue is a key test for this type of software tool," says U-M informatics fellow Jason Hipp, M.D., Ph.D., who shares lead authorship of the paper with resident Steven Christopher Smith, M.D., Ph.D. "This is the type of validation that has to happen before digital pathology tools can be widely used in a clinical setting."

To test the software's ability to identify cancer in a digital slide, a group of human pathologists first pinpointed the cancer the old fashioned way, by hand. Their work was then used as the gold standard for grading the program's results. Researchers then systematically tested which settings within the program produced the most accurate results which can serve as a blueprint for optimizing the software to detect other types of cancer and disease.

Diagnosing cancer and other pathologies from tissue slides has always been part science and part art. Pathologists pore over samples looking for certain structural anomalies or counting microscopic features.

But different pathologists or even the same pathologist at different times may come to different conclusions based on a number of factors, including whether a slide is viewed at high or low magnification, or even whether the pathologist is fatigued from examining dozens of other slides that day, the researchers say.

Digital tools like SIVQ can help pathologists to quickly, accurately and efficiently identify features on a slide with just a few clicks; to quickly calculate the area of an irregularly shaped feature; or to eliminate the slow and painstaking tallying of tiny elements.

Still, the authors stress, the program isn't intended to replace the skill and art of human pathologists, but to provide an additional resource.

"Not only do our findings show that SIVQ has the potential to be a useful tool in surgical pathologists' toolkits when optimized to aid detection of such a highly variable disease, but the case is an excellent example for how the same approach might be applied to a variety of clinical areas," says Ulysses Balis, M.D., director of the division of pathology informatics at U-M and the paper's senior author.

Balis led the software's design at U-M along with Hipp and former informatics fellow Jerome Cheng, M.D.

Unlike other pattern recognition software, SIVQ bases its matches on a set of concentric rings rather than the usual square block. This allows features to be identified no matter how they're rotated or whether they're flipped, as in a mirror.

An example of the program's flexibility was recently demonstrated by Bruce P. Levy, M.D., a research fellow in pathology at Harvard Medical School. Testing the program's utility in a forensic pathology setting, SIVQ was used to calculate the area of bullet wounds and to identify and quantify stippling, which are small scrapes surrounding some gunshot wounds that help to determine the distance from which a gun was fired.

"Being able to use software like SIVQ to analyze forensic images helps to bring the practice of forensic pathology closer to the high-tech fictional world of CSI," Levy says.

Since the computer-aided analysis of micropapillary urothelial carcinoma might contribute to patient care, the group is making all of their primary data freely available to other doctors and researchers at U-M's online digital imaging repository,

This paper marks the researchers' 11th SIVQ-related publication, including two editorials. Several others are currently in progress.


Contact: Ian Demsky
University of Michigan Health System

Related medicine news :

1. New Software Might Help Predict Difficult Childbirth
2. Mine-hunting software helping doctors to identify rare cells in human cancer
3. Sandias CANARY software protects water utilities from terrorist attacks and contaminants
4. New software hearing dummies pave the way for tailor-made hearing aids
5. Study shows pharmacies software systems miss potentially dangerous interactions
6. Digital imaging software to create a Google Earth view of the bladder
7. Research finds open-source software is actually more secure for health care IT
8. Resaerch finds open-source software is actually more secure for health care IT
9. Neurologists develop software application to help identify subtle epileptic lesions
10. 2 people receive kidney transplants in pilot program using CMU software
11. New Software for Defibrillators Lowers Risk of Unnecessary Shocks
Post Your Comments:
(Date:11/24/2015)... ... ... Serenity Point Rehabilitation, a holistic treatment center for substance abuse located in ... staff members at their recovery center. The videos highlight some of the various aspects ... things that make their recovery program so unique. , “Making the decision to seek ...
(Date:11/24/2015)... ... November 24, 2015 , ... Cold Shoulder , LLC launched their Pro Vest, the latest ... hit their goal of $20,000 in under 10 hours. , The campaign, ... PRO Weight Loss Vest to the market. , The PRO Vest provides consumers with a ...
(Date:11/24/2015)... ... ... Dr. Rodney E. Willey , has answered a new calling – to relieve snoring ... treatment for snoring and sleep apnea through oral appliance therapy. He is ... in the US, one of four in the Illinois area. , Dr. Willey’s ...
(Date:11/24/2015)... ... ... Bibliomotion is thrilled to announce the launch of UNCONVENTIONAL ... Nancy M. Schlichting, Chief Executive Officer of Henry Ford Health System (November ... of patients and their families, shaped my desire to improve the system of care. ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... products, announces Innovative Blending, a household invention that revolutionizes the vending machine industry ... Smoothie Bars market is worth $2 billion," says Scott Cooper, CEO and Creative ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... DELHI , November 25, 2015 ... invoked due to repeated failure of IVF cycles. After ... Bhatia was totally dejected and had lost all hopes that she would be ... first Indian miracle child conceived after failure of over ... to abroad (UK) before they decided to take one last attempt ...
(Date:11/24/2015)...  In the pharmaceutical industry, companies want to rapidly ... uncover new insights, tactics and strategies that will improve ... --> However, organizations often find it is difficult ... that all rules and regulations are met to ensure ... to efficiently launching market research projects is the conflicting ...
(Date:11/24/2015)... , November 24, 2015 --> ... report "Spine Biologics Market by Product Type (Bone Graft, Bine ... Discectomy and Fusion, Posterior Lumbar Interbody Fusion), End User, and ... global market was valued at $1.90 Billion in 2014 and ... CAGR of 4.4% during the forecast period of 2015 to ...
Breaking Medicine Technology: