Navigation Links
Sofosbuvir: Indication of added benefit for specific patients
Date:5/2/2014

own who receives which treatment. This poses the risk that patients discontinue the study prematurely depending on which treatment they were randomized to. This compromises the aim of randomization: the comparability of the treatment groups. This is exactly what happened in the FISSION study, which may lead to (highly) biased results.

Mortality and quality of life: added benefit not proven

As no deaths occurred in the FISSION study in the therapeutic indication genotype 2, there could be no differences between the treatment groups, and therefore no proof of added benefit, in the outcome "mortality". This also applies to health-related quality of life, but in this case because the dossier contained no evaluable data for this outcome.

Advantage in sustained virologic response

Instead of the patient-relevant outcome "development of hepatocellular carcinoma (HCC)", the manufacturer used sustained virologic response (SVR). It could show that there was a statistically significant group difference in favour of sofosbuvir. IQWiG conducted its own sensitivity analyses because of the high risk of bias. It tested how the effects changed when missing values were imputed with different strategies. The researchers found out that the result in favour of sofosbuvir was robust.

Valid surrogate for incidence of liver cancer

SVR is not itself a patient-relevant outcome and cannot be equated with "cure", and there are no studies in which SVR is validated as a surrogate outcome in accordance with the usual criteria employed by IQWiG. Nevertheless, the Institute accepts SVR here as a surrogate for the reduced incidence of liver cancer. This is because it is currently accepted that patients with no detectable hepatitis C virus in the blood are at lower risk of liver cancer. However, it is unclear how many cases of liver cancer can in fact be prevented by sofosbuvir.

For the outcome "secondary diseases", I
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Finnish research to revolutionise indications for knee surgery
2. Southwest Skin and Cancer Institute Employs Botox for New Indications
3. Global Vaccine Market Trends and Disease Indications Analysis with 2022 Forecasts in New Research Report at RnRMarketResearch.com
4. Apixaban in atrial fibrillation: Indications of considerable added benefit
5. Aflibercept in colorectal cancer: Indication of minor added benefit
6. Global Critical Care Market Will Reach $3.2 Billion in 2019 - Growth from Factor Concentrates, New Indications and Increasing Demand for Albumin in Asia-Pacific
7. Indication of considerable added benefit of vemurafenib in advanced melanoma
8. Antibody-coated stents: Indication of disadvantages
9. Abiraterone: Indication of considerable added benefit in certain patients
10. Turoctocog alfa in patients with hemophilia A: Added benefit not proven
11. Geriatric health professionals experience added burden when caring for own family members
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of ... area has treated just about every type of injury that ... And for those same twenty-plus years, the team at Doctors ... with the best possible doctor. With the combined breadth ...
(Date:1/22/2015)... York, NY (PRWEB) January 22, 2015 ... College of Sports Medicine flagship journal Medicine & ... with L-Citrulline before exercise may help reduce gastrointestinal ... exercise. 1 , Participants in the double-blind, ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 IsoComforter, Inc. ... therapy machine with patented IsoTube design to treat specific body ... introduced the most progressive and easy to use patented cold ... post-operative and sports related orthopedic and muscle injuries. IsoComforter ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 EBSCO Information ... (AMA) are expanding their relationship in an effort to further ... the world. While EBSCO has long made AMA journals available ... sales agent for The JAMA Network. , Long ...
(Date:1/22/2015)... released a new blog post presenting a list of vehicles that ... , Some types of vehicles cannot be covered under an ordinary ... to see if their vehicle qualifies for auto insurance coverage. ... cars that cannot be covered by a plan. Clients have little ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... -- Exercising in young adulthood boosts bone density, new research ... of over 800 Swedish men aged 19 to 24 and ... period also showed increased bone density in the hips, arms ... activity decreased during that period had significantly more "brittle" bones, ...
... Julio Montaner of the British Columbia Centre for Excellence ... published in this week,s PLoS Medicine that the cost-effectiveness ... economic analyses have not yet taken into account the ... The authors comment: "the strategic value of ...
... have taken a remarkably detailed look at the initial steps ... first develops in a child or young adult. The ... the University of Rochester Medical Center who have expertise both ... children from ages 8 to 18 within 48 hours of ...
... A unique board game developed by a group of ... between various health disciplines to better educate students about ... Western,s Schulich School of Medicine & Dentistry began developing ... ethics project, and now it,s been professionally reproduced for ...
... THURSDAY, Feb. 16 (HealthDay News) -- Marital harmony may be ... in online games such as World of Warcraft, Lord of ... one spouse spends time in this online fantasyland, it can ... of recreation management at Brigham Young University. In ...
... February 16, 2012 -- Soldiers in the National Guard ... risk of developing alcohol-related problems during and after deployment, ... and Alcohol Dependence journal. Researchers at Columbia University,s ... other institutions found that the soldiers at greatest risk ...
Cached Medicine News:Health News:As diabetes emerges, researchers track disease's first steps 2Health News:As diabetes emerges, researchers track disease's first steps 3Health News:As diabetes emerges, researchers track disease's first steps 4Health News:Online Medieval Fantasy Games -- Threat to Marital Bliss? 2Health News:National guardsmen face a high risk of developing alcohol abuse problems following deployment 2
(Date:1/23/2015)... a third of reproductive-aged women enrolled in Medicaid, and more ... prescription for an opioid pain medication each year during 2008-2012, ... Weekly Report (MMWR). Opioids are typically prescribed ... They are also found in some prescription cough medications. The ...
(Date:1/23/2015)... , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( ... of directors of Advaxis, Inc. ("Advaxis" or the "Company") ... has breached its fiduciary duties to shareholders. ... an investing website reporting that Advaxis had misrepresented the ...
(Date:1/23/2015)... 2015  HyGreen, Inc., a leader in hand hygiene monitoring, ... Medical, a subsidiary of Ascendis Health Limited, in ... year, hundreds of millions of patients around the world ... transmitted from patient to patient via the unwashed hands ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
... ,Faces of Influenza, Karen Newman and LaShell Griffin Asking,Everyone, Especially Mothers, to Protect Themselves and Their Families ... and Every Year ... Photo Opportunity/Media Advisory, DETROIT, Dec. 11 , WHAT: Kristi Yamaguchi, Olympic ... Detroit Red Wings" LaShell Griffin, Oprah,s Pop ...
... More Resources and Take,Aggressive Steps to Prevent MRSA ... aren,t doing enough to protect patients from,Methicillin-resistant Staphylococcus ... infection control professionals released today., The online ... Control (APIC) found that 59 percent of those ...
Cached Medicine Technology:Olympic Gold Medalist Kristi Yamaguchi Joins American Lung Association of Michigan to Address Seriously Low Vaccination Rates; Urge Metro-Detroiters to Get Immunized This Season 2Olympic Gold Medalist Kristi Yamaguchi Joins American Lung Association of Michigan to Address Seriously Low Vaccination Rates; Urge Metro-Detroiters to Get Immunized This Season 3Survey Finds U.S. Healthcare Facilities Not Doing Enough to Curb MRSA 2Survey Finds U.S. Healthcare Facilities Not Doing Enough to Curb MRSA 3
... H. pylori Rapid Test Strip and Device ... detection of antibodies to Helicobacter pylori (H. ... to aid in the diagnosis of H. ... age and older. They are intended for ...
Immunoassay for rapid, qualitative detection of IgG antibodies specific to Helicobacter pylori in whole blood....
Clearview H. pylori II uses rapid, two-step technology for the direct detection of H. pylori antibodies. , ,The patented, innovative technology used by Clearview H. pylori II provides highly sen...
... Uni-Gold™ H. pylori assay is intended ... detection of IgG antibodies to Helicobacter ... serum, plasma or whole blood as ... H. pylori infection in patients with ...
Medicine Products: