Navigation Links
Sofosbuvir: Indication of added benefit for specific patients
Date:5/2/2014

The drug sofosbuvir has been available since January 2014 as a treatment for chronic hepatitis C infection. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) has now examined whether the new drug offers added benefit in comparison with the appropriate comparator therapy.

The dossier submitted by the drug manufacturer provides indications of added benefit for non-pretreated patients infected with the virus of genotype 2. However, the extent cannot be quantified. There were no suitable data in the dossier for patients who are infected with other virus types (genotype 1 and 3 to 6) or who are coinfected with HIV.

An addition to previous standard drug therapy

Hepatitis C viruses attack the liver and can trigger inflammation there. If this becomes chronic, cirrhosis can develop and liver function progressively deteriorates. Moreover, the risk of liver cancer increases. Sofosbuvir inhibits the reproduction of hepatitis C viruses and is administered in addition to the drugs peginterferon alfa and ribavirin, which are already on the market; in certain cases it is administered in addition to ribavirin alone. According to the approval, treatment duration differs for the individual patient groups.

The dual combination of peginterferon alfa and ribavirin is the current treatment standard; in genotype 1, this also applies to a triple combination with boceprevir or telaprevir (triple therapy) in most patients.

The Federal Joint Committee (G-BA) therefore specified peginterferon alfa and ribavirin as appropriate comparator therapy, and, in genotype 1, triple therapy as additional option.

No adequate analyses for most virus types

The manufacturer presented no adequate analyses for infection with type 1 and type 3 to 6 viruses and for HIV coinfection. It analysed results
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Finnish research to revolutionise indications for knee surgery
2. Southwest Skin and Cancer Institute Employs Botox for New Indications
3. Global Vaccine Market Trends and Disease Indications Analysis with 2022 Forecasts in New Research Report at RnRMarketResearch.com
4. Apixaban in atrial fibrillation: Indications of considerable added benefit
5. Aflibercept in colorectal cancer: Indication of minor added benefit
6. Global Critical Care Market Will Reach $3.2 Billion in 2019 - Growth from Factor Concentrates, New Indications and Increasing Demand for Albumin in Asia-Pacific
7. Indication of considerable added benefit of vemurafenib in advanced melanoma
8. Antibody-coated stents: Indication of disadvantages
9. Abiraterone: Indication of considerable added benefit in certain patients
10. Turoctocog alfa in patients with hemophilia A: Added benefit not proven
11. Geriatric health professionals experience added burden when caring for own family members
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... The print component of Vision and Hearing is ... Toronto Star, with a circulation of approximately 230,433 copies ... is distributed nationally through a vast social media strategy ... partner outlets. To explore the digital version of the ... an exclusive interview with Mark DeMontis , sharing ...
(Date:12/19/2014)... Potentially illness-causing E. coli bacteria were found on nearly ... a new study. Researchers checked cilantro, basil and ... in Los Angeles and Orange counties in California, and ... tested, 24 percent were positive for E. coli. One ... Both types of bacteria can cause sometimes serious ...
(Date:12/19/2014)... 2014 (HealthDay News) -- Older adults who have lost all ... than people who still have at least some of their ... total tooth loss could provide an early warning of increased ... British researchers said. However, the findings don,t prove that ... study included more than 3,100 participants 60 and older. People ...
(Date:12/19/2014)... LENEXA, Kan. (PRWEB) December 19, 2014 ... dedicated exclusively to healthcare providers, has been retained to ... for Estes Park Medical Center in Estes Park, Colo. ... B. E. Smith has recently placed more than 900 ... Center (EPMC) is a 25-bed, not-for-profit critical access hospital ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Hands On Mobile ... available. The Spa On Wheels has been transformed into ... from the outside world seems to disappear. The Virtual Tour ... massages, facials, spa parties, corporate events and more. , The ... Spa On Wheels which is actually an overhauled Winnebago. Marla ...
Breaking Medicine News(10 mins):Health News:Mark DeMontis, Founder of Courage Canada, shares his passion for bringing hockey to those affected by blindness in Mediaplanet’s “Vision and Hearing” campaign 2Health News:E. Coli Germs Found on Farmers Market Herbs 2Health News:Loss of Teeth Linked to Physical, Mental Decline in Study 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 2Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 3
... of British Columbia have identified new breast cancer genes ... and form the basis of next-generation treatments. Researchers ... based on the genetic fingerprint of a tumour. Many ... cancer biology, allowing doctors to predict whether a tumour ...
... and quality-of-life issues should be considered essential elements of ... point of breast cancer diagnosis. However, for women suffering ... other medically underserved areas around the world, this fundamental ... To address these issues, many of the world,s ...
... HealthDay Reporter , TUESDAY, April 17 (HealthDay News) ... they enter the Part D "donut hole," the seniors ... essential for heart health, new research shows. "We looked ... three and half months during a year. While we didn,t ...
... Carina Storrs HealthDay Reporter , TUESDAY, April 17 ... could one day help diagnose teens with depression. To ... depression. Then they tested the markers in a small group ... distinguish the teens with major depression from those without depression. ...
... , HOUSTON - Scientists who developed a technology for identifying ... surface have found a way to penetrate the outer membrane ... inside the cell. In a paper published today online ... at The University of Texas MD Anderson Cancer Center reports ...
... , , , , , ... AUDIO: New research in half siblings adds to evidence that even though autism is far ... Click here for more information. , , , ... , , , , , , ...
Cached Medicine News:Health News:Scientists rewrite rulebook on breast cancer in landmark global study 2Health News:Scientists rewrite rulebook on breast cancer in landmark global study 3Health News:International breast health global summit will focus on supportive care and quality of life 2Health News:International breast health global summit will focus on supportive care and quality of life 3Health News:Seniors Stop Taking Heart Drugs In Medicare 'Donut Hole' 2Health News:Seniors Stop Taking Heart Drugs In Medicare 'Donut Hole' 3Health News:Researchers Develop Blood Test for Depression 2Health News:Researchers Develop Blood Test for Depression 3Health News:Scientists tailor cell surface targeting system to hit organelle ZIP codes 2Health News:Scientists tailor cell surface targeting system to hit organelle ZIP codes 3Health News:Study of half siblings provides genetic clues to autism 2Health News:Study of half siblings provides genetic clues to autism 3Health News:Study of half siblings provides genetic clues to autism 4Health News:Study of half siblings provides genetic clues to autism 5
(Date:12/19/2014)... KANSAS CITY, Kan. , Dec. 18, 2014 ... PETX ), a biopharmaceutical company focused on ... for companion animals, today announced positive results from ... company,s innovative drug for treating pain in dogs ... demonstrated improvements in pain assessment scores that were ...
(Date:12/17/2014)... and SAN DIEGO , Dec. 17, 2014 ... ; AEX: PHIA) and Volcano Corporation (NASDAQ: VOLC ... for cardiovascular applications, today announced that they have entered into ... commence a tender offer to acquire all of the issued ... or a total equity purchase price of USD 1 billion ...
(Date:12/17/2014)... , Dec. 17, 2014  Strategic Health Services, Inc. ... solutions, today announced a strategic agreement with QualCare, Inc., a ... New Jersey regional marketplace.  This agreement will ... health and wellness solutions QualCare brings to its clients ... surrounding region. QualCare plans cover more ...
Breaking Medicine Technology:Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 2Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 3
... 2012  InterMune, Inc. (NADSAQ: ITMN) today reported ... announced its decision granting the additional benefit ... treatment of mild-to-moderate idiopathic pulmonary fibrosis (IPF).  ... 4 (not quantifiable benefit)  in the rating ...
... March 15, 2012 Reportlinker.com announces that ... in its catalogue: ... http://www.reportlinker.com/p0578259/Vaccines---Asia.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_and_Medication This market research report ... actual market situation, trends and future outlook ...
Cached Medicine Technology:Esbriet® (pirfenidone) Benefit Granted by German Federal Joint Committee (G-BA) 2Esbriet® (pirfenidone) Benefit Granted by German Federal Joint Committee (G-BA) 3Esbriet® (pirfenidone) Benefit Granted by German Federal Joint Committee (G-BA) 4Esbriet® (pirfenidone) Benefit Granted by German Federal Joint Committee (G-BA) 5Esbriet® (pirfenidone) Benefit Granted by German Federal Joint Committee (G-BA) 6Vaccines - Asia 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: