Navigation Links
Sodium channel blocker shows promise as a potential treatment for cystic fibrosis
Date:5/17/2009

ATS 2009, SAN DIEGOCystic fibrosis patients may benefit from a new therapy that increases airway hydration, preventing the buildup of mucous, which is a key factor in the disease, according to researchers at Parion Sciences in Durham, N.C.

The research will be presented on Sunday, May 17, during the American Thoracic Society's 105th International Conference in San Diego.

"Our results suggest that we have identified a new agent that acts directly on a specific pathway, which is involved in the development of cystic fibrosis," said lead author Andrew Hirsh, Ph.D., senior director of drug discovery and preclinical development for Parion Sciences.

In normal respiration, the moist surface of the airway allows individuals to effectively clear mucous, keeping airways open and viable. But in individuals with cystic fibrosis, the hydration level of the airway is altered and the airway mucous builds up, interfering with normal respiration. One of the mechanisms causing airways to not clear mucous correctly in these patients involves the body's natural homeostasis of sodium which, when absorbed too quickly from the surface of the airway, causes moisture to become absorbed too quickly.

"Cystic fibrosis patients have a genetic ion transport defect, which decreases the hydration level on the airway surface and therefore reduces the body's ability to effectively clear mucous, which is a primary defense mechanism of the respiratory system," Dr. Hirsh said. "Diminished mucous clearance leads to chronic respiratory infection and impaired pulmonary function. Currently there are no therapies available to specifically target this channel in patients with cystic fibrosis."

The aerosol-based therapy uses a specific epithelial sodium channel-blocking agent called GS-9411, which prevents sodium from being absorbed across the airway, allowing the surface to remain moist. The increase in moisture allows individuals to more effectively clear the airway of mucous and infectious agents.

This study was performed during the pre-clinical stage of development to compare GS-9411 to an established epithelial sodium channel blocker, called amiloride. Currently, GS-9411 is in Phase I clinical trials being conducted by Parion's development partner, Gilead Sciences, Inc., in Foster City, CA.

During the study, researchers applied GS-9411 to airway surface cells grown in the laboratory, and assessed the potency and reversibility of the drug on these cells. Results of the study indicated GS-9411 allowed the cells to retain liquid for more than eight hours. Concurrent animal studies revealed that the agent enhanced mucous clearance for more than four hours.

The results offer new hope for cystic fibrosis sufferers, according to Dr. Hirsh. "The potency and the length of time that the drug was effective in cells and in animal studies was an outstanding feature that distinguishes this compound from other agents," he said.

The clinical phase of the drug development cycle will enable researchers to continue to refine the treatment for eventual distribution to cystic fibrosis patients.

"GS-9411 administered by aerosol can effectively increase airway surface liquid and enhance mucous clearance in an animal model," he said. "The results demonstrate that GS-9411 warrants further investigation as a new drug therapy to decrease respiratory infection and improve pulmonary function."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Health Alliance Announces First Fracture Protection Program for Actonel(R) (risedronate sodium) Tablets
2. Perrigo Announces FDA Approval for Sulfacetamide Sodium Topical Suspension USP, 10% (Lotion)
3. Watson Pharmaceuticals and Elan Settle Lawsuit Over Naproxen Sodium
4. Grocery Manufacturers Association Releases Science Policy Paper on Sodium and Salt
5. Sodium, Potassium Intake Tied to Heart Disease
6. Consumer Reports Identifies Foods With Surprisingly High Levels of Sodium
7. Watson Announces District Court Ruling in Naproxen Sodium Patent Suit
8. Lupin Receives USFDA Approval for Divalproex Sodium Delayed-Release Tablets
9. Low-sodium advice for asthmatics should be taken with a pinch of salt
10. Low-sodium advice for asthmatics should be taken with a grain of salt
11. Roxane Laboratories, Inc. Initiates a Nationwide Voluntary Recall of Two Manufacturing Lots of Sodium Polystyrene Sulfonate Suspension in the US and Puerto Rico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... Florida (PRWEB) , ... May 31, 2016 , ... ... Jay Butch of CertainTeed Corporation, he knew it was something that contractors should ... state-of-the-art and cutting-edge as it gets,” says Butch, CertainTeed’s Director of Contractor Programs. ...
(Date:5/31/2016)... ... ... Effective leaders not only drive service to the next level, they also ... Northbound CEO Mike Neatherton and COO Paul Alexander will be taking part in the ... The Journey to Authenticity” with Onsite Workshops CEO Miles Adcock and Vice President of ...
(Date:5/31/2016)... Francisco, CA (PRWEB) , ... May 31, 2016 , ... ... cases for digital-minded professionals, announces the waxed-canvas and leather Duo Dopp Kit , ... durable waxed canvas or ballistic nylon, the Duo is smartly designed for ...
(Date:5/31/2016)... ... May 31, 2016 , ... Interest is on the rise for ... as an orthogonal tool for RNAi hit validation. A key reason may be that ... rapid generation of CRISPR RNA (crRNA) collections in arrayed formats. , Arrayed ...
(Date:5/31/2016)... ... 31, 2016 , ... MinerEye today announced that it has ... report by Gartner1 Inc. , Each year, Gartner identifies new Cool Vendors in ... vendors and their products and services. , According to Gartner, “Gartner's Cool Vendors ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 2016 194 Mitgliedsstaaten ... Eliminierung von viraler Hepatitis    Am ... eingegangen, virale Hepatitis bis 2030 zu eliminieren. ... Assembly haben sich die Staaten einstimmig dafür entschieden, ... Viral Hepatitis Strategy) zu verabschieden, was das bisher ...
(Date:5/30/2016)... ALBANY, New York , May 30, 2016 /PRNewswire/ ... new market report titled, "Advanced (3D/4D) Visualization Systems Market ... Forecast 2016 - 2024." According to the report, the ... US$ 1.8 Bn in 2015 and is anticipated to ... 2024 to reach US$ 3.2 Bn in 2024. ...
(Date:5/30/2016)... According to a new ... by Type (Stability, Raw Materials, Method Validation, Microbial, ... Companies, Medical Device Companies) - Global Forecast to ... growth during the last decade and is expected ... 2016 and 2021 to reach USD 4.13 Billion ...
Breaking Medicine Technology: