Navigation Links
Sodium buildup in brain linked to disability in multiple sclerosis
Date:7/16/2012

OAK BROOK, Ill. A buildup of sodium in the brain detected by magnetic resonance imaging (MRI) may be a biomarker for the degeneration of nerve cells that occurs in patients with multiple sclerosis (MS), according to a new study published online in the journal Radiology.

The study found that patients with early-stage MS showed sodium accumulation in specific brain regions, while patients with more advanced disease showed sodium accumulation throughout the whole brain. Sodium buildup in motor areas of the brain correlated directly to the degree of disability seen in the advanced-stage patients.

"A major challenge with multiple sclerosis is providing patients with a prognosis of disease progression," said Patrick Cozzone, Ph.D., director emeritus of the Center for Magnetic Resonance in Biology and Medicine, a joint unit of National Center for Scientific Research (CNRS) and Aix-Marseille University in Marseille, France. "It's very hard to predict the course of the disease."

In MS, the body's immune system attacks the protective sheath (called myelin) that covers nerve cells, or neurons, in the brain and spinal cord. The scarring affects the neurons' ability to conduct signals, causing neurological and physical disability. The type and severity of MS symptoms, as well as the progression of the disease, vary from one patient to another.

Dr. Cozzone, along with Wafaa Zaaraoui, Ph.D., research officer at CNRS, Jean-Philippe Ranjeva, Ph.D., professor in neuroscience at Aix-Marseille University and a European team of interdisciplinary researchers used 3 Tesla (3T) sodium MRI to study relapsing-remitting multiple sclerosis (RRMS), the most common form of the disease in which clearly defined attacks of worsening neurologic function are followed by periods of recovery. Sodium MRI produces images and information on the sodium content of cells in the body.

"We collaborated for two years with chemists and physicists to develop techniques to perform 3T sodium MRI on patients," Dr. Zaaraoui said. "To better understand this disease, we need to probe new molecules. The time has come for probing brain sodium concentrations."

Using specially developed hardware and software, the researchers conducted sodium MRI on 26 MS patients, including 14 with early-stage RRMS (less than five years in duration) and 12 with advanced disease (longer than five years), and 15 age- and sex-matched control participants.

In the early-stage RRMS patients, sodium MRI revealed abnormally high concentrations of sodium in specific brain regions, including the brainstem, cerebellum and temporal pole. In the advanced-stage RRMS patients, abnormally high sodium accumulation was widespread throughout the whole brain, including normal appearing brain tissue.

"In RRMS patients, the amount of sodium accumulation in gray matter associated with the motor system was directly correlated to the degree of patient disability," Dr. Zaaraoui said.

Current treatments for MS are only able to slow the progress of the disease. The use of sodium accumulation as a biomarker of neuron degeneration may assist pharmaceutical companies in developing and assessing potential treatments.

"Brain sodium MR imaging can help us to better understand the disease and to monitor the occurrence of neuronal injury in MS patients and possibly in patients with other brain disorders," Dr. Ranjeva said.


'/>"/>
Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Poor Sleep May Age Your Brain
2. Low-cal diets effects seen in fly brain, mouthpart
3. Brain power shortage
4. Exercise Can Shield the Aging Brain, Studies Show
5. Mayo Clinic creates tool to track real-time chemical changes in brain
6. The Ben & Catherine Ivy Foundation contributes $10 million to TGen for brain cancer research
7. Brain Scans Using New Dye May Predict Alzheimers
8. Strong communication between brain and muscle requires both having the protein LRP4
9. Better treatment for brain cancer revealed by new molecular insights
10. Pediatric tumors traced to stem cells in developing brain​​
11. Electrical brain stimulation can alleviate swallowing disorders after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2019)... ... October 15, 2019 , ... Labeling for Prescription Drugs, Biologics ... FDAnews Webinar**, Tuesday, October 29, 2019, 1:30-3:00 p.m. EDT, https://www.fdanews.com/labelpredrug, , ... drug applications and biologics license applications? , How will the current content and ...
(Date:10/15/2019)... ... October 15, 2019 , ... Nashville Fertility Center (NFC) is proud to ... to join the practice. In addition to treating general infertility, Dr. Van Heertum offers ... at NFC looks forward to Dr. Van Heertum joining the practice and believes she ...
(Date:10/11/2019)... ... ... A Topping Out event was hosted today at the construction site of the ... The event celebrated reaching the final height of the structure set to open in ... kind in Texas, STA’s facility will be home to an organ recovery center including ...
(Date:10/10/2019)... ... October 10, 2019 , ... Caring.com, a leading senior care referral ... and Worst Places for Seniors to Live. All 50 states and 302 cities in ... life and workforce development. , According to the U.S. Census Bureau , ...
(Date:10/8/2019)... , ... October 08, 2019 , ... What unique insights ... future state of aging and wellness in the nation? That question will be answered ... Aging Conference, Leadership Summit and Expo. The event will take place October 10-12, 2019, ...
Breaking Medicine News(10 mins):
(Date:10/11/2019)... (PRWEB) , ... October 11, 2019 , ... Based on ... see a 9 percent increase in deceased organ donors over 2018. Through August 31, ... and Transplantation Network (OPTN) national database . At this pace, the Association of ...
(Date:10/10/2019)... (PRWEB) , ... October 10, 2019 , ... ... Parkinson Championships , 2019 ITTF Parkinson World Table Tennis Championships, October 11th – ... play music and perform in public. So, he sought to find a way ...
(Date:10/9/2019)... ... October 09, 2019 , ... The 11th annual American ... Science and AMI Meditation for the relief and prevention of physician burnout. Entitled ... 22-26, 2019 at the Cranwell Resort and Spa in Lenox, Massachusetts, is certified ...
Breaking Medicine Technology: