Navigation Links
Sodium MRI gives new insights into detecting osteoarthritis, NYU researchers find
Date:8/27/2010

Researchers at New York University have developed an innovative way to look at the development of osteoarthritis in the knee jointone that relies on the examination of sodium ions in cartilage. Their work, which appears in the Journal of Magnetic Resonance, may provide a non-invasive method to diagnose osteoarthritis in its very early stages.

The concentration of sodium ions, which are distributed in the body, is known to reveal the location of glycosaminogycans (GAGs) in cartilage tissues. GAGs are molecules that serve as the building blocks of cartilage and are involved in numerous vital functions in the human body. Mapping the GAG concentration is necessary for the diagnosis and monitoring of a number of diseases as well as to determine the efficacy of drug therapies. For instance, GAG loss in cartilage typically marks the onset of osteoarthritis and inter-vertebral disc degeneration.

However, the existing techniques for GAG monitoringbased on traditional magnetic resonance imaging (MRI)have limitations: they cannot directly map GAG concentrations or they require the administration of contrast agents to reveal the location of these concentrations.

But since sodium ions are already present in cartilage, researchers have sought to measure these ions using special MRI techniques that are non-invasive.

Such a methodology was previously developed at the University of Pennsylvania and Stanford University. However, these methodologies were not able to isolate ions in different parts of the knee area. Specifically, they could not make clear-cut distinctions between signals of slow motion sodium ions in the cartilage from those of free sodium ions in synovial fluid and joint effusion in the knee joint.

The NYU research team sought to improve on this method by focusing on the differences in the properties of sodium ions in the two environments.

Since sodium is present not only in cartilage, MRI images often cannot tell whether the sodium concentration measured is located in cartilage or elsewhere in the knee joint. To better target where these sodium concentrations reside, the researchers focused on the differences in the magnetic behavior of sodium ions residing in different tissues. By exploiting these characteristic properties of sodium ions in different environments, the research team was able to develop a new method to isolate two pools of sodium ions. As a result, it was able to obtain images in which the sodium signals appear exclusively from regions with cartilage tissue.

This new sodium MRI method not only could provide a non-invasive way to diagnose osteoarthritis in its very early stages, but could also help to calibrate other, less direct measures of cartilage assessments.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related medicine news :

1. Sen. Barbara Boxer Commends California Poultry Companies and Cites Foster Farms Campaign for Raising Consumer Awareness About Sodium
2. Experts call for accelerated national sodium reduction initiatives
3. Stethoscope App gives iPhone New Clinical Skills
4. Pacific Dental Services Gives Smiles to More Than 400 Children
5. New Book Gives Physicians the Business Know-how to Find the Right Medical Practice
6. Brain Balancing Gives Hope for Sufferers of Depression, Stress, and Insomnia at New Life Brain Center
7. Hearing Aids Wearers Alert! Weber's New Hearing Aids Liner Gives More Comfort Saves Cost Of Re-Molding
8. Los Angeles Plastic Surgeon Christine Petti, MD Gives Patients an Evening of Beauty
9. U discovery gives insight into brain replay process
10. A Mother's Day Gift that Gives Lasting Joy
11. Stirling Dental Laboratory, Experts in Emergency Denture Repair Service, Gives Back to Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Story Highlights: ... the health care industry is causing providers to review ... Deloitte offers a suite of solutions for health care ... cost optimization: labor resource analysis, revenue cycle optimization and ... outcomes and better economics ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: