Navigation Links
Sodium Buildup in Brain Linked to Disability in MS Patients

TUESDAY, July 17 (HealthDay News) -- Sodium buildup in the brain seems to be linked to disability in people with multiple sclerosis, researchers have found.

This accumulation of sodium could be an indicator of the degeneration of nerve cells that results from the disease, according to a team of European researchers. Although multiple sclerosis, or MS, symptoms vary from patient to patient, the study authors suggested that their findings may help predict the severity of disease progression and disability.

"A major challenge with multiple sclerosis is providing patients with a prognosis of disease progression. It's very hard to predict the course of the disease," Patrick Cozzone, director emeritus of the Center for Magnetic Resonance in Biology and Medicine, a joint unit of National Center for Scientific Research and Aix-Marseille University in Marseille, France, said in a news release from the Radiological Society of North America.

In conducting the study, the researchers used a specific type of imaging technology that provides information on the sodium content of cells in the body, known as 3 Tesla sodium MRI. The test was performed on 26 patients with relapsing-remitting MS, the most common form of the disease, in which flare-ups of symptoms are followed by periods of recovery.

Of the study's participants, 14 had early stage relapsing-remitting MS and 12 had advanced forms of the disease. The researchers also examined 15 healthy participants without MS that they matched for the patients' ages and genders.

"We collaborated for two years with chemists and physicists to develop techniques to perform [3 Tesla] sodium MRI on patients," Wafaa Zaaraoui, research officer at the National Center for Scientific Research, said in the news release. "To better understand this disease, we need to probe new molecules. The time has come for probing brain sodium concentrations."

The MRI results for patients with early stage relapsing-remitting MS revealed abnormally high levels of sodium in certain areas of the brain, including the brainstem, cerebellum and temporal pole. High sodium accumulation was found throughout the entire brains of patients with advanced forms of the disease -- even in brain tissue that appeared to be normal, the researchers found.

When sodium collected in areas of the brain responsible for motor skills, there was a direct connection to the level of disability seen in people with advanced-stage MS, the researchers noted.

"In [relapsing-remitting MS] patients, the amount of sodium accumulation in gray matter associated with the motor system was directly correlated to the degree of patient disability," said Zaaraoui.

The study authors suggested that their findings might help drug companies in developing new MS treatments.

"Brain sodium MRI can help us better understand the disease and monitor the occurrence of neuronal injury in MS patients and possibly in patients with other brain disorders," Jean-Philippe Ranjeva, professor of neuroscience at Aix-Marseille University, concluded in the news release.

The study was published in the July 17 online edition of the journal Radiology.

Although the study uncovered an association between sodium buildup in the brain and MS disability, it did not prove a cause-and-effect relationship.

More information

The U.S. National Library of Medicine has more about multiple sclerosis.

-- Mary Elizabeth Dallas

SOURCE: Radiological Society of North America, news release, July 17, 2012

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Sodium buildup in brain linked to disability in multiple sclerosis
2. Poor Sleep May Age Your Brain
3. Low-cal diets effects seen in fly brain, mouthpart
4. Brain power shortage
5. Exercise Can Shield the Aging Brain, Studies Show
6. Mayo Clinic creates tool to track real-time chemical changes in brain
7. The Ben & Catherine Ivy Foundation contributes $10 million to TGen for brain cancer research
8. Brain Scans Using New Dye May Predict Alzheimers
9. Strong communication between brain and muscle requires both having the protein LRP4
10. Better treatment for brain cancer revealed by new molecular insights
11. Pediatric tumors traced to stem cells in developing brain​​
Post Your Comments:
Related Image:
Sodium Buildup in Brain Linked to Disability in MS Patients
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from reveals that ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: