Navigation Links
Social Isolation Adversely Affects Breast Cancer
Date:9/29/2009

In mouse study, those living alone had larger tumors than those in groups

TUESDAY, Sept. 29 (HealthDay News) -- A socially isolated, stressful environment can speed up the growth of breast cancer, researchers studying the effects of stress in animal models reported Tuesday.

Social isolation can actually change the expression of genes important in the growth of mammary gland tumors, according to Dr. Suzanne D. Conzen, an associate professor of medicine at the University of Chicago and the study's lead author.

"As far as we know, this is the first assessment of gene expression in mammary glands, looking at the molecular basis for differences in tumor development under the setting of social stress," Conzen said at a news conference Tuesday.

The findings, published in the October issue of Cancer Prevention Research, follow other studies, some in humans, that showed stress can adversely impact cancer. One study, for instance, found that stressful marriages are bad for breast cancer recovery.

Conzen and her colleagues randomly assigned mice that were genetically susceptible to breast cancer to live either in isolation or in group housing.

"We separated the mice at a very young age, just a few days after they had been weaned from their mothers' milk," Conzen said. "Mice are social animals. In the wild, they live in groups of three or four. They have dramatic responses to isolation."

"What we found was the isolated mice developed larger and more breast cancers than the group-housed mice," she added.

Three and a half weeks into the isolation, Conzen's team measured gene expression in the animals' mammary glands, the equivalent of the human breast. "We found very reproducible changes in gene expression [in the isolated mice]. We found genes that were turned on and turned off that had to do with metabolism," she said. These pathways are known to contribute to increased growth of breast cancer, she added.

The isolated mice also had a higher corticosterone stress hormone response than did the group-housed mice.

The changes in the expression levels of metabolic pathway genes occurred in the isolated mice even before the tumor size differences were able to be measured, Conzen said.

So what are the practical applications of the research?

The findings may suggest molecular biomarkers, or targets, for preventive intervention in breast cancer, she said.

"Many questions remain," Conzen added. "One of the things we did note is that the isolated animals were much more vigilant, less exploratory. They released more of a stress hormone when we added another stressor to the situation [besides the isolation]."

Thea Tisty, a pathology professor at the University of California, San Francisco, who is familiar with the findings, called the research "a very exciting beginning."

The implication is that perceived or actual stress from outside can affect which genes get turned on or off. If the research findings bear out, it could lead to a way to catch tumors in their formation before they become tumors and suppress them, she said.

Another expert speaking at the briefing cautioned that the findings, while exciting, are only preliminary and based only on animal studies.

"This is an area that has a long way to go in terms of understanding how these factors play out in humans," said Caryn Lerman, the Mary W. Calkins Professor of Psychiatry at the Abramson Cancer Center at the University of Pennsylvania in Philadelphia.

More information

To learn more about stress and cancer, visit the National Cancer Institute.



SOURCES: Suzanne D. Conzen, M.D., associate professor of medicine, Ben May Department for Cancer Research, University of Chicago; Thea Tisty, Ph.D., professor of pathology, University of California, San Francisco; Caryn Lerman, Ph.D., Mary W. Calkins Professor of Psychiatry, Abramson Cancer Center, University of Pennsylvania, Philadelphia; October, 2009 Cancer Prevention Research


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Dow Jones Sustainability Index Again Recognizes Abbott for Continued Leadership in Business, Environmental and Social Performance
2. Cognitive Activities Protect Against Alzheimers -- Social and Physical Activities Not Enough
3. MJGC Welcomes New Director of Social Work Alla Lerner
4. Civil Rights and Medical Leaders Call for Social Justice in Health Care
5. Multicountry review shows that Bug Buster Kits reduce head lice and social stigma
6. Hartford Foundation awards grant to address geriatric social work shortage
7. Study to consider social risk in guiding prevention of heart disease
8. IOM advisory: improving cancer patients psychosocial care
9. Cancer care providers need to proactively address patients psychological and social needs
10. Penn wins $5M to start center for ethical, legal and social implications research
11. Social Justice Issues Take Main Stage at Egypts National Democratic Party Convention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Woolsy ... nutraceutical supplements, through its Nova Skin Sciences division, recently announced the launch of ... moisturizer with the power of an anti-aging concentrate. , Anogeissus Leiocarpa ...
(Date:4/28/2017)... NY (PRWEB) , ... April 28, 2017 , ... ... celebrating its 5th anniversary. SearchLight is the premier online modeling resource for fluorescence ... more than 30,000 active users during last 5 years spanning the globe, SearchLight ...
(Date:4/27/2017)... , ... April 27, 2017 , ... ... Insights in Incentives, Rewards, and Recognition: A Nudge Guide," a groundbreaking analysis of ... field. Offering practical takeaways to apply immediately to IRR programs, the report highlights ...
(Date:4/27/2017)... Minneapolis, Minnesota (PRWEB) , ... April 27, 2017 ... ... Smith and her husband Dan Gasby the 2017 Public Leadership in Neurology Award ... Bob Woodruff, retired professional athlete Tedy Bruschi, Vice President Walter Mondale, actor Michael ...
(Date:4/27/2017)... ... 27, 2017 , ... Goodcents Deli Fresh Subs announced a franchise expansion agreement ... year. , The first new location will open at the corner of 27th ... and Northern Lights Drive this fall. And the third location is in the process ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Cogentix Medical, ... focused on providing the Urology, Uro/Gyn and Gynecology ... that Ash Keswani has joined the Company as ... this newly created position, Mr. Keswani will report ... CEO. "Our organization is delighted that ...
(Date:4/20/2017)... Research and Markets has announced ... Market Prospects: Addressing Production Complexities Through Risk Management and ... ... Pipeline and Market Prospects: Overcoming Production Complexities Through Risk ... of the current trends in the global biosimilars market, ...
(Date:4/20/2017)... 2017  CVS Pharmacy, the retail division of ... store design to enhance the retail customer experience ... products and expanded beauty selections paired with informational ... new offerings. Together with its innovative digital programs, ... customer experience at CVS Pharmacy.  ...
Breaking Medicine Technology: