Navigation Links
Sniffing out lymphoma by turning dogs into humans
Date:4/6/2011

Researchers at North Carolina State University are narrowing the search for genes involved in non-Hodgkin lymphoma by turning dogs into humans.

Humans and dogs don't just share companionship and living space, they also share a similar genetic makeup. Additionally, they share the same types of cancer, including lymphoma. Dr. Matthew Breen, professor of genomics at NC State, uses canines as a genetic model for studying lymphoma because purebred dogs of the same breed have less genetic variation among them than humans do, making it easier to pinpoint areas on canine chromosomes that may be involved with cancer.

In a paper published in the journal Leukemia and Lymphoma, Breen's team took the genetic information from dogs with non-Hodgkin lymphoma, and then rearranged or "recoded" the genomes of the dogs so that, genomically speaking, they were human. The researchers then compared the recoded canine genomes with those of humans with non-Hodgkin lymphoma, to see which chromosomes were involved with the cancer in both humans and canines.

"This is the first time that we were able to compare this information from dogs with lymphoma directly with existing data from human patients diagnosed with the equivalent cancer and using the same technique," says Dr. Rachael Thomas, research assistant professor of molecular biomedical sciences at NC State and lead author of the paper.

The data revealed that there were only a few genes involved with lymphoma that were shared by dogs and humans. This is in contrast to current research into human lymphoma, where numerous genes have been identified as possibly having a relationship to the cancer. Breen and his colleagues hope that this data will point researchers toward the most likely genetic culprits.

"In essence, we stripped the background noise from the human data," Breen says. "Lymphoma genomics is a lot more complex in human patients than in dog patients. This study tells us that while both humans? and dogs? have comparable disease at the clinical and cellular level, the genetic changes associated with the same cancers are much less complex in the dog. This suggests that maybe there is a lot of genetic noise in the human cancers that are not essential components of the process. While human studies have been looking in numerous places in the genome, the dog data indicate we need to focus on what's shared, and these are very few regions."


'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Related medicine news :

1. Sniffing Device Allows Disabled to Write, Run Wheelchairs
2. Urine-sniffing dogs: Early detection of prostate cancer
3. New class of drug kills lymphoma cells
4. Vitamin K may protect against developing non-Hodgkins lymphoma, say Mayo Clinic researchers
5. Scott & White Healthcare clinical trials target lymphoma, leukemia
6. Lifestyle factors significantly impact survival of non-Hodgkins lymphoma patients, study finds
7. Lifestyle Affects Survival in Non-Hodgkins Lymphoma
8. Study identifies promising treatment for aggressive lymphoma
9. Study shows Hodgkin lymphoma survivors lack post-treatment screening for other cancers
10. Lymphoma Survivors Often Miss Out on Follow-Up
11. Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial ... financial preparation services, is providing an update on a charitable event that began ... Rescue is a locally recognized nonprofit that provides shelter and care for animals ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's ... President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. ... 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with ... for the primary prevention of cardiovascular diseases during the 15th Annual Women’s ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  True Health, ... has amplified its effort during National Breast Cancer ... hereditary cancer risks. ... Clinical Oncology calculated that more than 10 million ... inherited mutations in BRCA1 or BRCA2 and have not ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology: