Navigation Links
Smoking increases potential for metastatic pancreatic cancer
Date:7/27/2009

(PHILADELPHIA) Smoking has once again been implicated in the development of advanced cancer. Exposure to nicotine by way of cigarette smoking may increase the likelihood that pancreatic ductal adenocarcinoma will become metastatic, according to researchers from the Kimmel Cancer Center at Jefferson. Their study was published in the August edition of the journal Surgery.

The culprit behind the increased metastasis potential appears to be an isoform (variant type) of a protein called osteopontin, according to Hwyda Arafat, M.D. Ph.D., an associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University and a member of the Jefferson Pancreatic, Biliary & Related Cancers Center.

Nicotine promotes the expression osteopontin, and high levels of osteopontin have been reported in pancreatic ductal carcinoma (PDA). Dr. Arafat and her research team analyzed PDA samples and confirmed that the isoform, called OPNc, was also expressed on invasive PDA lesions. Previous studies have shown that OPNc is expressed in several invasive cancers, and supports metastatic behavior.

The researchers correlated OPNc expression with the patients' smoking history. OPNc expression was found on 87 percent of the invasive PDA lesions analyzed, of which 73 percent were from smokers. The OPNc expression also correlated with higher expression levels of osteopontin. Premalignant lesions expressed no OPNc.

"This is the first time a relationship between nicotine and OPNc expression has been identified," Dr. Arafat said. "These data are very exciting because now we can evaluate OPNc as a prognostic and diagnostic marker of invasive PDA lesions. "Because of the lower expression levels of OPNc in non-smokers, OPNc may be regulated by nicotine, which is another novel finding of this study. The exact role of OPNc in PDA remains to be defined, but it could provide a unique potential target to control pancreatic cancer aggressiveness, especially in people who smoke cigarettes."

Pancreatic cancer is the fourth-leading cause of cancer death in the country, taking 34,000 lives a year. Only four percent of individuals with pancreatic cancer live for five years after diagnosis.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Smoking increases risks for head and neck cancers for men and women
3. Smoking Boosts Risk for Head, Neck Cancers
4. AUDIO from Medialink and Commit Lozenge: Wanna Quit Smoking With Therapeutic Nicotine? Just Follow the Directions
5. Passive smoking increases sleep disturbance among pregnant women
6. Teens who see more smoking in movies may have increased risk of becoming established smokers
7. Smoking in Movies May Put Teens at Risk
8. Test Spots Genetic Damage Done by Smoking
9. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
10. Muslim Groups Kick Off Ramadan With Anti-Smoking Initiative
11. Smoking can harm the long-term effects of some oral surgery procedures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... Fairfax, VA (PRWEB) , ... April 28, 2017 , ... ... elected volunteer board members and officers for 2017-2018. The annual board election process has ... serving on a volunteer basis. , Thomas C. Dickerson, Ed.D., FACHE, succeeds Jim Hamilton, ...
(Date:4/28/2017)... ... April 28, 2017 , ... The Texas Cord Blood Bank (TCBB), a program ... delivery team at Women’s Hospital at Renaissance in Edinburg for their outstanding efforts in ... and decide to donate. , “Women’s Hospital at Renaissance has been a collection ...
(Date:4/28/2017)... ... 2017 , ... People are starting to accept that hearing aids can be ... the stigma it had when great-grandpa wore his hearing aids years ago,” said Dr. ... North American Speaker Series (NASS) segment. “He probably wore an iPod-size hearing ...
(Date:4/28/2017)... ... April 28, 2017 , ... Researchers at ... ActiGraph’s CentrePoint Data Hub in a sample of participants enrolled in ... activity and sleep monitoring solutions for the global scientific community. The company’s new ...
(Date:4/28/2017)... ... April 28, 2017 , ... Woolsy Corporation Limited, ... through its Nova Skin Sciences division, recently announced the launch of Allumière Antiaging ... the power of an anti-aging concentrate. , Anogeissus Leiocarpa Bark Extract ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017 The Mobile X-Ray product segment is ... CAGR during the forecast period Mobile X-Ray segment ... digital mobile X-Ray devices market, which is estimated to be ... at a CAGR of 7% over the forecast period. Mobile ... more than US$ 100 Mn in 2017 over 2016. The ...
(Date:4/19/2017)... 19, 2017 The Global Effective Microorganisms ... 2022 report has covered and analysed the potential of Global ... market size, shares and growth factors. The report identifies and ... opportunities in the global market. ... Browse 152 Tables and Figures, 6 Major Company Profiles, ...
(Date:4/19/2017)... THOUSAND OAKS, Calif. , April 19, 2017 ... premium industrial buildings it is developing at Conejo ... California , to Atara Biotherapeutics, Inc. ... patients with severe and life-threatening diseases that have ... focus on allogeneic T-cell therapies for cancer, autoimmune ...
Breaking Medicine Technology: