Navigation Links
Smoking increases potential for metastatic pancreatic cancer
Date:7/27/2009

(PHILADELPHIA) Smoking has once again been implicated in the development of advanced cancer. Exposure to nicotine by way of cigarette smoking may increase the likelihood that pancreatic ductal adenocarcinoma will become metastatic, according to researchers from the Kimmel Cancer Center at Jefferson. Their study was published in the August edition of the journal Surgery.

The culprit behind the increased metastasis potential appears to be an isoform (variant type) of a protein called osteopontin, according to Hwyda Arafat, M.D. Ph.D., an associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University and a member of the Jefferson Pancreatic, Biliary & Related Cancers Center.

Nicotine promotes the expression osteopontin, and high levels of osteopontin have been reported in pancreatic ductal carcinoma (PDA). Dr. Arafat and her research team analyzed PDA samples and confirmed that the isoform, called OPNc, was also expressed on invasive PDA lesions. Previous studies have shown that OPNc is expressed in several invasive cancers, and supports metastatic behavior.

The researchers correlated OPNc expression with the patients' smoking history. OPNc expression was found on 87 percent of the invasive PDA lesions analyzed, of which 73 percent were from smokers. The OPNc expression also correlated with higher expression levels of osteopontin. Premalignant lesions expressed no OPNc.

"This is the first time a relationship between nicotine and OPNc expression has been identified," Dr. Arafat said. "These data are very exciting because now we can evaluate OPNc as a prognostic and diagnostic marker of invasive PDA lesions. "Because of the lower expression levels of OPNc in non-smokers, OPNc may be regulated by nicotine, which is another novel finding of this study. The exact role of OPNc in PDA remains to be defined, but it could provide a unique potential target to control pancreatic cancer aggressiveness, especially in people who smoke cigarettes."

Pancreatic cancer is the fourth-leading cause of cancer death in the country, taking 34,000 lives a year. Only four percent of individuals with pancreatic cancer live for five years after diagnosis.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Smoking increases risks for head and neck cancers for men and women
3. Smoking Boosts Risk for Head, Neck Cancers
4. AUDIO from Medialink and Commit Lozenge: Wanna Quit Smoking With Therapeutic Nicotine? Just Follow the Directions
5. Passive smoking increases sleep disturbance among pregnant women
6. Teens who see more smoking in movies may have increased risk of becoming established smokers
7. Smoking in Movies May Put Teens at Risk
8. Test Spots Genetic Damage Done by Smoking
9. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
10. Muslim Groups Kick Off Ramadan With Anti-Smoking Initiative
11. Smoking can harm the long-term effects of some oral surgery procedures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... DC (PRWEB) , ... March 23, 2017 , ... News ... Dental Choice has helped score a major victory in Europe for public health and ... , Based on rigorous scientific research and the overwhelming support of European ...
(Date:3/23/2017)... ... March 23, 2017 , ... “A Respectful Response To ... Response To Atheist Manifesto” is the creation of published author Richard Hostetter, a ... sixty years. He holds graduate degrees from Kent State University and the University ...
(Date:3/22/2017)... ... March 22, 2017 , ... Cosmetic Town, an ... issue of its companion print magazine. The new magazine, scheduled for release in ... information provided by board-certified doctors from across the country. , According to the ...
(Date:3/22/2017)... ... ... Old School Labs™, makers of the best-selling Vintage line of natural sports ... who trained with Floyd Mayweather, made his professional debut in London in 2003 and ... number of wins in contests in Britain, Germany and the U.S. , “We ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... today announced that its digital marketing solutions have enabled Children’s Hospital of The ... 24 months. , Recognizing the value of a digital marketing approach, the ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017 TapImmune, ... specializing in the development of innovative peptide and ... metastatic disease, today announced that it will participate ... Dr. Glynn Wilson , Chairman and ... the company,s business, clinical pipeline and partnering opportunities ...
(Date:3/22/2017)... 22, 2017 Piramal Pharma Solutions ... held a special event to introduce the new and ... Lexington, Kentucky . The inaugural event was attended ... Ajay Piramal, and Piramal Pharma Solutions CEO, ... ...
(Date:3/22/2017)... ROCHESTER, N.Y. , March 22, 2017 /PRNewswire/ ... Steriliz R-D™ Rapid Disinfector™ is the proven ultraviolet-C ... that cause healthcare-associated infections (HAIs). ... American Journal of Infection Control , the peer-reviewed ... testing and experiences of Vancouver General Hospital and ...
Breaking Medicine Technology: