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Smoking during pregnancy increases risk of SIDS
Date:5/30/2008

able to those of moderate to heavy smoking human mothers and the infants born to them.

A total of 30 control and 39 cigarette smoke-exposed one-week-old rat pups were randomized to undergo either thermoneutral or hyperthermic exposure to an oxygen-depleted environment. Researchers then analyzed the respiratory responses to the challenges.

Overall, just 13 percent of the control animals exhibited gasping, whereas nearly three times that36 percentof the cigarette smoke exposed animals did. Furthermore, none of the control animals exhibited gasping under hypoxic conditions during thermoneutral experiments, whereas 25 percent of the cigarette smoke exposed animals did. Under hyperthermic conditions, just 29 percent of the control group displayed gasping behavior, compared to nearly half49 percentof the cigarette smoke exposed group. These results also indicate the adverse effects of low oxygen and thermal stress even in pups, which were not exposed to cigarette smoke during pregnancy, said Dr. Hasan.

But the effects were much more pronounced in pups that head been exposed to cigarette smoked prenatally. Under hyperthermic conditions, hypoxia induced gasping in both groups, but only the cigarette smoke-exposed animals exhibited a pronounced and longer lasting respiratory depression following the termination of hypopxia.

Our results show that prenatal cigarette smoke exposure compounds the risk by increasing the likelihood of gasp-like respiration and prolonging the time that it takes for neonates to return to normal breathing following hypoxia, said Dr. Hasan. These observations provide important evidence of how prenatal cigarette smoke exposure, hypoxic episodes and hyperthermia might place infants at higher risk for SIDS and further support efforts to foster prenatal smoking cessation programs.


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Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

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