Navigation Links
Smoking causes asthma in second generation offspring
Date:10/29/2012

The dangers of smoking on smokers and their children are widely known but new research published in BioMed Central's open access journal BMC Medicine demonstrates that nicotine exposure also causes asthma in the smoker's grandchildren.

Asthma is a major public health problem. It is the most common chronic disease of childhood. While there are many factors which contribute to asthma maternal smoking during pregnancy is a well known, and avoidable, risk.

During pregnancy nicotine can affect a developing foetus' lungs, predisposing the infant to childhood asthma. Researchers from Harbor-UCLA Medical Centre, California, tested the effect of nicotine exposure during pregnancy on rats, looking not only at their pups (F1) but also at second generation pups (F2).

Exposure inside the uterus resulted in both male and female (F1) offspring having reduced lung function consistent with asthma. It also impaired lung function of their own offspring (F2), even though the F1 rats were not themselves exposed to nicotine once they were born. Levels of proteins increased by maternal smoking in the lungs of their offspring such as fibronectin, collagen and nicotinic aceylcholine receptors, were also found to be raised in the grandchildren. Similarly the expression of PPARγ, a normal lung development, was reduced in first and second generation offspring.

Dr Virender Rehan, who led this study commented, "When we looked at the effect of nicotine on DNA in the testes or ovaries of the rats they found that nicotine increased the level of methylation in the testes but reduced it in the ovaries. Nicotine also altered methylation of histones in a sex-dependent manner. These epigenetic marks may be the mechanism behind how nicotine-induced asthma is transmitted from one generation to the next."

Treating the mothers with a synthetic version of PPARγ, known to normalise lung function in nictotine exposed offspring also prevented lung damage to F2 offspring and restored normal histone modification patterns in their lungs.

The effects of smoking during pregnancy are, it seems, very long lasting. Stop smoking education and intervention aimed at mothers-to-be and women planning pregnancy needs to take into account the fact that nicotine itself contains dangers to their children and their children's children.
'/>"/>

Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Related medicine news :

1. Anti-tobacco TV ads help adults stop smoking, study finds
2. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
3. Small neural focus groups predict anti-smoking ad success
4. Some women may be genetically predisposed to smoking-related hot flashes
5. Friends Parents Can Sway Teens Odds for Drinking, Smoking
6. Fewer Young Americans Smoking, Survey Finds
7. Vitamin C improves pulmonary function in newborns of pregnant smoking women
8. Genetic marker may predict smoking quantity in African Americans
9. 5 percent of workers gave up smoking when the anti-tobacco law took effect
10. Vitamin C improves lung function in newborns of pregnant smoking women
11. States Use Only Fraction of Tobacco Revenues to Fight Smoking, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
Breaking Medicine Technology: