Navigation Links
Smoking Ups Infection Risk for Lung Disease Patients
Date:4/7/2009

It lowers immune system's defense to bacteria that threaten those with COPD, study says

TUESDAY, April 7 (HealthDay News) -- Not only does smoking help cause chronic obstructive pulmonary disease (COPD), it may cripple the body's immune response to bacteria that can worsen the disease, Canadian researchers report.

The finding, detected in a study involving mice, may influence how smokers with COPD are treated, the experts said.

"It is well established that smoking is the main risk factor for COPD. But our research also suggests that cigarette smoke substantially changes the immune response to bacteria, which means that patients with COPD who smoke are weakening their body's ability to deal effectively with bacterial invaders. This may cause even further progression of the disease," principal investigator Martin Stampfli, an associate professor at McMaster University in Hamilton, Ontario, said in an American Thoracic Society news release.

In the study, one group of mice was exposed to cigarette smoke twice a day for five days a week for eight weeks, while another group of mice was exposed to cigarette smoke for four days. After the cigarette smoke exposure, both groups of mice received a dose of nontypeable Haemophilus influenzae (NTHI) bacteria, which causes many COPD exacerbations.

Mice in a control group weren't exposed to cigarette smoke but were inoculated with NTHI.

Both groups of mice exposed to cigarette smoke showed distinct changes in their immune response, specifically an increase in inflammation in the lungs, after being inoculated with NTHI. They also had increased weight loss in response to bacterial infection and a shift in the expression of inflammatory markers.

The study was published in the second April issue of the American Journal of Respiratory and Critical Care Medicine.

If further research confirms these findings, "they would indicate that treatment targets for smokers with COPD may be markedly different than in non-smokers. Smoking may change the underlying inflammatory pathways elicited after bacterial infection," Stampfli said.

More information

The American Academy of Family Physicians has more about COPD.



-- Robert Preidt



SOURCE: American Thoracic Society, news release, April 7, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Smoking increases risks for head and neck cancers for men and women
3. Smoking Boosts Risk for Head, Neck Cancers
4. AUDIO from Medialink and Commit Lozenge: Wanna Quit Smoking With Therapeutic Nicotine? Just Follow the Directions
5. Passive smoking increases sleep disturbance among pregnant women
6. Teens who see more smoking in movies may have increased risk of becoming established smokers
7. Smoking in Movies May Put Teens at Risk
8. Test Spots Genetic Damage Done by Smoking
9. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
10. Muslim Groups Kick Off Ramadan With Anti-Smoking Initiative
11. Smoking can harm the long-term effects of some oral surgery procedures
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Smoking Ups Infection Risk for Lung Disease Patients
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
(Date:10/12/2017)... ... 12, 2017 , ... Leading pediatric oncology experts at Children’s National Health ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired ... Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief ...
(Date:10/12/2017)... ... 12, 2017 , ... In the United States, single-family home ... states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is ... low property-tax rates, which contributes to the relatively lower cost of living in ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  BioPharmX Corporation (NYSE ... team that developed an innovative way to use nonlinear ... the delivery of new drugs. ... Clinical Dermatology Conference will show how researchers from BioPharmX ... Harvard Medical School used a suite of imaging techniques ...
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: