Navigation Links
Smoking Could Harm Sperm, Study Finds
Date:9/9/2010

By Alan Mozes
HealthDay Reporter

THURSDAY, Sept. 9 (HealthDay News) -- Two new studies provide evidence that smoking can harm sperm - both in smoking men who may become fathers, and in sons born to women who smoked during pregnancy.

The research also suggests that both men and women who hope to conceive should kick the habit.

"The results of the present study suggest a negative biological effect of smoking on spermatozoa DNA integrity," said the lead author of one study, Dr. Mohamed E. Hammadeh, head of the assisted reproductive laboratory in the department of obstetrics and gynecology at the University of the Saarland in Saar, Germany.

Research by Hammadeh and his colleagues showed that men who smoke heavily may experience fertility problems stemming from a drop in levels of a protein crucial to sperm development, as well as damage to sperm's DNA.

Another study suggests that women who smoke early in their pregnancy may ultimately compromise their sons' reproductive health.

Both studies are published in the Sept. 8 online issue of Human Reproduction.

In the first study, Hammadeh's team compared sperm from 53 heavy smokers (more than 20 cigarettes a day) against that of 63 nonsmokers.

After three to four days of sexual abstinence, a single semen sample was taken from all study participants, to measure levels of two forms of a specific type of protein found in sperm, called protamines. According to the researchers, protamines are key players in sperm development, helping to spur on the process by which chromosomes are formed and packaged during cell division.

Hammadeh and colleagues found that in the smoking group, one form of protamine appeared at levels that were 14 percent below concentrations observed in the sperm of nonsmoking men. This was enough to constitute a form of "protamine deficiency" and, in turn, raise risks for infertility among the smokers.

What's more, smoking-linked "oxidative stress" appeared tied to an increase in damage to sperm DNA, the team reported.

According to Hammadeh, past attempts to clarify the relationship between cigarette smoking and male infertility have had trouble identifying a molecular mechanism underlying any such link. So he believes the new finding should help convince male smokers struggling with infertility to kick the habit.

"Because of the fact that cigarette smoke contains mutagens and carcinogens, there have been concerns that smoking may have adverse effects on male reproduction," Hammadeh noted. The new findings help bear that out, he said.

The second study was led by Dr. Claus Yding Andersen, a professor of human reproductive physiology at the University Hospital of Copenhagen in Denmark. It focused on the impact of maternal smoking during the first trimester of pregnancy upon the development of the male fetus.

In this case, the authors analyzed tissue from the testes of 24 embryos that had been aborted between 37 and 68 days following conception.

After classifying the prospective mothers according to smoking habits, the research team found that the number of so-called "germ cells" -- cells that develop into sperm in males and eggs in females -- were 55 percent lower in the testes of embryos obtained from women who smoked. This observation held regardless of the mother's alcohol and coffee consumption habits.

As well, embryonic levels of so-called "somatic cells" (those that go on to form other types of tissue) were 37 percent lower among those women who smoked.

In both the case of germ and somatic cells, drop-offs in levels appeared to be "dose-dependent," meaning that the more the prospective mother smoked, the lower the number of cells grown by the embryo.

Based on these findings early in fetal growth, Anderson and his colleagues conclude that the apparent impact of smoking on cellular production might continue in male offspring carried to term. And that could mean a higher risk of impaired fertility in sons.

According to the Danish team, their earlier research involving female embryos also revealed "germ cell" reductions of about 40 percent for embryos taken from women who smoked during pregnancy. This suggests that maternal smoking in pregnancy may harm the reproductive health of both male and female offspring.

"Our results provide health care professionals who talk to women who are considering conceiving, or have conceived just recently, with a 'here and now' argument to convince them to stop smoking," Anderson said. "Because the negative effect of smoking appears to take place right from conception and during the early days [of gestation], when the human embryo becomes differentiated into either a girl or a boy."

More information

There's more on the dangers of smoking during pregnancy at the March of Dimes.

SOURCES: Mohamed E. Hammadeh, M.D., department of obstetrics and gynecology, University of the Saarland, Saar, Germany; Claus Yding Andersen, M.D., professor, human reproductive physiology, and technology ambassador, University Hospital of Copenhagen, Laboratory, Copenhagen, Denmark; Sept. 8, 2010, Human Reproduction, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Decline in Adult Smoking Stalls, Alarming Experts
2. Penn receives $12 million NIH grant to research personalized approach to smoking cessation
3. Stopping smoking cessation treatments too soon may reduce odds of success for 45 percent of smokers
4. Governments should pay for smoking cessation therapies
5. Smoking increases depressive symptoms in teens
6. ADHD, conduct disorder and smoking most strongly related to dropping out of high school
7. Wood smoke exposure multiplies damage from smoking, increases risk of COPD
8. Smoking influences gene function, scientists say
9. Smoking mind over smoking matter
10. Decline in U.S. Teen Smoking Rate Stalls
11. People Living With Lung Cancer Are Too Often Stigmatised Because Of Link To Smoking
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Smoking Could Harm Sperm, Study Finds
(Date:2/12/2016)... ... February 12, 2016 , ... According to an ... beginning to account for a significant portion of hernia repairs throughout the United States. ... Beverly Hills Hernia Center notes that this trend has not only been expected, but ...
(Date:2/12/2016)... ... ... CDRH Enforcement Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. ... “Those who don’t learn from history are doomed to repeat it.” , An analysis of ... year. But that takes time. , Take a close look at the warning letters ...
(Date:2/12/2016)... ... 2016 , ... T.E.N., a technology and information security executive ... Awards 2016. Finalists and winners of the ISE® Awards for both Executive and ... Gala on March 15, 2016 at the Westin Peachtree Plaza, Atlanta. , ...
(Date:2/12/2016)... ... , ... AssureVest Insurance Group, a locally owned insurance firm with offices serving ... funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and 3rd grade ... a low-income area and has more than 60 2nd and 3rd graders with learning ...
(Date:2/12/2016)... San Ramon, CA (PRWEB) , ... February 12, 2016 , ... ... tissue donation in northern California and Nevada, announced a partnership with San Ramon Regional ... be transferred to the hospital’s facilities as a way to accommodate a more certain ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... North Carolina , 12 februari 2016 ... Inc. (AAI/CML), een toonaangevende leverancier van productie ... en biotechnologische industrieën, kondigt vandaag een uitbreiding ... mogelijkheden op haar locatie in ... vraag heeft geleid tot meerdere recente investeringen. ...
(Date:2/12/2016)... 2016 --> ... Inflammation Global Clinical Trials Review, H2, 2015 provides ... clinical trials landscape along with top level data ... (G7 & E7), Trial Status, Trial Phase, Sponsor ... companies involved and enlists all trials (Trial title, ...
(Date:2/11/2016)... 2016 Stem cells are primitive cells found ... and the capacity to differentiate into mature cell types ... the first mouse embryonic stem cells were derived from ... that the first culturing of embryonic stem cells from ... produced until 2006 As a result of these discoveries, ...
Breaking Medicine Technology: