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Smoking, Diabetes, Obesity May Shrink Your Brain
Date:8/1/2011

By Maureen Salamon
HealthDay Reporter

MONDAY, Aug. 1 (HealthDay News) -- As if there weren't already enough good reasons to avoid smoking and keep your weight, blood sugar levels and blood pressure all under control, a new study suggests these risk factors in middle age may cause your brain to shrink, leading to mental declines up to a decade later.

Evaluating data from 1,352 participants whose average age was 54 in the Framingham Offspring Study -- which began in 1971 -- researchers from the University of California, Davis found that smoking, high blood pressure, diabetes and being overweight were each linked to potentially dangerous vascular changes in the brain.

"We can't cure disease or cure aging, but the idea of a healthy body, healthy mind is very real," said study author Dr. Charles DeCarli, director of UC Davis' Alzheimer's Disease Center. "People should stop smoking, control their blood pressure, avoid diabetes and lose weight. It seems like a no-brainer."

The study is published Aug. 2 in the journal Neurology.

Participants were given blood pressure, cholesterol and diabetes tests and had their body mass and waist circumference measured. They also underwent MRI brain scans over the course of a decade, the first one about seven years after the initial risk factor exam.

Those with stroke and dementia were excluded at the outset, and between the first and last MRIs 19 participants suffered a stroke and two developed dementia.

Those with high blood pressure experienced a more rapid worsening of test scores of planning and decision-making, which corresponded to a faster rate of growth of small areas of vascular brain damage than those with normal blood pressure.

Those with diabetes in middle age experienced brain shrinkage in an area known as the hippocampus faster than those without, and smokers lost brain volume overall and in the hippocampus faster than nonsmokers, with a m
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