Navigation Links
Smokers undergo the same changes in gene expression as patients with COPD
Date:5/9/2011

'Healthy' smokers experience changes in the gene expression of their lungs similar to that suffered by smokers who have developed Chronic Obstructive Pulmonary Disease (COPD). This is the conclusion of a new study, led by Catalan researchers, which confirms the crucial role that smoking plays in causing these alterations.

"Our objective was to analyse the expression of a range of genes in the pulmonary tissue samples of patients with COPD, whether smokers or not, and people who had undergone operations for cancer or lung transplants", Ricardo Bastos, lead author of the study and a researcher at the August Pi i Sunyer Biomedical Research Institute (IDIBAPS), tells SINC.

Using the real-time polymerase chain reaction (PCR) technique, the scientists analysed the expression of 42 genes related with processes such as tissue and vascular inflammation and change. Previous data already existed on the involvement of some of the proteins that code these genes in causing and developing the disease.

The authors then compared the expression profile of these genes between patients with moderate and severe COPD, 'healthy' smokers with normal lung function, and non-smokers. The main result of these studies was that the gene expression profile in the patients with moderate COPD was very similar to that of the 'healthy' smokers.

"The 'healthy' smokers experience similar gene expression changes as those seen in smokers who have developed the disease", concludes Bastos. "This once again underlines the decisive role of smoking in causing these changes".

In fact, these two groups have a more similar gene expression profile than patients with moderate and severe COPD. Previous laboratory studies have shown that the structural and cellular lung changes (to the airways and pulmonary arteries) of 'healthy' smokers are very similar to those in smokers with slight or moderate COPD.

The world's fourth leading cause of death

COPD is characterised by limited air flow, which is progressive and irreversible, caused by an abnormal inflammatory response in the lung, which at advanced stages can lead to the patient's death. All current treatments are merely symptomatic and palliative. Experts insist on the need to develop new therapies to help slow down the progression of the disease.

It is the most common respiratory disease caused by smoking which is the most important risk factor. It has high prevalence and mortality rates in industrialised and developing countries. Forecasts issued by the World Health Organisation (WHO) suggest that COPD will become the world's fourth leading cause of death (it is currently the sixth) by 2020.


'/>"/>

Contact: SINC
info@plataformasinc.es
0034-914-251-820
FECYT - Spanish Foundation for Science and Technology
Source:Eurekalert  

Related medicine news :

1. Brain imaging demonstrates that former smokers have greater willpower
2. For Nonsmokers, Healthy Living Cuts Death Rate in Half: Study
3. Many Smokers Still Deceived by Cigarette Labeling
4. Smokers believe silver, gold and slim cigarettes are less harmful
5. Blood Test Holds Hope for Spotting Lung Cancer in Nonsmokers
6. Babies Who Sleep in Smokers Rooms Face Thirdhand Smoke
7. Children of women who smoked during pregnancy at increased risk of becoming smokers
8. New targeted drug helps smokers stub it out
9. Prevalence of heavy smokers in US decreases
10. Text Messages May Help Smokers Kick the Addiction, Small Study Finds
11. Simple blood test detects early emphysema in smokers before symptoms appear
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Smokers undergo the same changes in gene expression as patients with COPD
(Date:5/25/2016)... ... May 25, 2016 , ... ... (KOHP), a $500,000 two-year pilot initiative to improve oral health-related awareness, education, prevention ... development for health care providers and promote best practices in 10 New Jersey ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... There was a time when tampons and ... going with the flow and turning to menstrual cups, like Lunette . To make ... is introducing their new anthem in this catchy video ! , It’s easy ...
(Date:5/25/2016)... Dallas, Texas (PRWEB) , ... May 25, 2016 , ... ... B. Myers Veterans Biomedical Technology Program to help provide veterans a pathway to employment ... Market Executive, presented a $20,000 check to Nick Hallack, President and CEO of Medisend, ...
(Date:5/25/2016)... , ... May 25, 2016 , ... ... Provider, announces that Lake City Bank has selected IFN as a fiber transport ... access, resulting in increased efficiencies and reduced costs. , “IFN provides ...
(Date:5/25/2016)... York, NY (PRWEB) , ... May 25, 2016 ... ... Medicine and Florida International University (FIU) Herbert Wertheim College of Medicine announced the ... a Medical Doctor Degree and Global Health Certificate from AUA and a Certificate ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... -- According to Kalorama Information, the world market for ... these are challenging times in the market, there ... companies that remain optimistic and seek innovation.  Toward ... medical device companies spend a higher percentage of ... do companies in other industries.  Also, in addition ...
(Date:5/25/2016)... According to market research "Global ... Demand Forecast to 2022 - Industry Insights by Type ... by P&S Market Research, the global insulin delivery device ... it is expected to grow at a CAGR of ... segment is expected to witness the fastest growth at ...
(Date:5/25/2016)... 2016 As illustrated by the ... month, the numbers and momentum of cannabis in the ... the billions, more research and development push the sector ... of Legal Marijuana Markets Report  from from ArcView Market ... of the increase in sector is attributed to adult ...
Breaking Medicine Technology: