Navigation Links
Smokers undergo the same changes in gene expression as patients with COPD
Date:5/9/2011

'Healthy' smokers experience changes in the gene expression of their lungs similar to that suffered by smokers who have developed Chronic Obstructive Pulmonary Disease (COPD). This is the conclusion of a new study, led by Catalan researchers, which confirms the crucial role that smoking plays in causing these alterations.

"Our objective was to analyse the expression of a range of genes in the pulmonary tissue samples of patients with COPD, whether smokers or not, and people who had undergone operations for cancer or lung transplants", Ricardo Bastos, lead author of the study and a researcher at the August Pi i Sunyer Biomedical Research Institute (IDIBAPS), tells SINC.

Using the real-time polymerase chain reaction (PCR) technique, the scientists analysed the expression of 42 genes related with processes such as tissue and vascular inflammation and change. Previous data already existed on the involvement of some of the proteins that code these genes in causing and developing the disease.

The authors then compared the expression profile of these genes between patients with moderate and severe COPD, 'healthy' smokers with normal lung function, and non-smokers. The main result of these studies was that the gene expression profile in the patients with moderate COPD was very similar to that of the 'healthy' smokers.

"The 'healthy' smokers experience similar gene expression changes as those seen in smokers who have developed the disease", concludes Bastos. "This once again underlines the decisive role of smoking in causing these changes".

In fact, these two groups have a more similar gene expression profile than patients with moderate and severe COPD. Previous laboratory studies have shown that the structural and cellular lung changes (to the airways and pulmonary arteries) of 'healthy' smokers are very similar to those in smokers with slight or moderate COPD.

The world's fourth leading cause of death

'/>"/>
Contact: SINC
info@plataformasinc.es
0034-914-251-820
FECYT - Spanish Foundation for Science and Technology
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Brain imaging demonstrates that former smokers have greater willpower
2. For Nonsmokers, Healthy Living Cuts Death Rate in Half: Study
3. Many Smokers Still Deceived by Cigarette Labeling
4. Smokers believe silver, gold and slim cigarettes are less harmful
5. Blood Test Holds Hope for Spotting Lung Cancer in Nonsmokers
6. Babies Who Sleep in Smokers Rooms Face Thirdhand Smoke
7. Children of women who smoked during pregnancy at increased risk of becoming smokers
8. New targeted drug helps smokers stub it out
9. Prevalence of heavy smokers in US decreases
10. Text Messages May Help Smokers Kick the Addiction, Small Study Finds
11. Simple blood test detects early emphysema in smokers before symptoms appear
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Smokers undergo the same changes in gene expression as patients with COPD
(Date:8/22/2014)... LSU Health New Orleans School of Nursing was ... to increase access to advanced nursing education and ... as well as veterans. The Health Resources and ... and Human Services awarded the two-year grant. Scharalda ... project director., The Advanced Education Nursing Traineeship (AENT) ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Beat ... how they can use natural methods to completely cure ... caught the attention of Shane Michaels, prompting an investigative ... that affects the skin, it can still be extremely ... reports Michaels. “The intense itching and pain that it ...
(Date:8/22/2014)... a complex autoimmune disease that affects 1 to ... only cope with pain, disability and joint disfigurements, ... family life and marital functioning. While many pharmacological ... disability is common. In addition, some patients avoid ... side effects. Because of this, there is interest ...
(Date:8/22/2014)... Chicago, IL (PRWEB) August 22, 2014 ... become a thriving fertility destination, and now offers the ... interdisciplinary team of infertility specialists. The fertility network of ... an overall commitment to world-class reproductive care, female and ... program lives up to the standards so eminently set ...
(Date:8/22/2014)... 22, 2014 (HealthDay News) -- Back-to-school time provides an ... fits into the family schedules, an expert suggests. ... school year can also be the start of a ... a professor of kinesiology at the University of the ... With kids, extracurricular activities likely to build up, ...
Breaking Medicine News(10 mins):Health News:Beat Eczema: Review Exposes Susan Clark’s Guide to Curing Eczema Naturally 2Health News:Study shows cognitive-behavioral coping skills training has positive effects on rheumatoid arthritis 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 4Health News:With Kids in School, Parents Can Work Out 2
... July 2008 Elsevier, a leading publisher of scientific, technical ... the official journal of the European Association of Urology ... , European Urology (also the "Platinum ... response and an international profile. To keep up with the ...
... Milwaukee-based Assurant Health, a,leading national provider of ... products, announces that Jennifer Kopps-Wagner has been,named ... immediately., Kopps-Wagner joined Assurant Health in ... company,s legal department. In her most recent ...
... LOUIS, July 16 Stereotaxis, Inc. (Nasdaq:,STXS) announced ... Heart and,Diabetes Center of North Reinland-Westphalia in Bad ... in a 10-year old boy. The team performed ... Pulmonary atresia is a congenital malformation of the ...
... New Center for Excellence Issue Brief, WASHINGTON, ... Government Excellence has issued its first issue brief ... Local Government Retiree Health,Benefit Plans: Myths and Realities. ... professor of economics and management, innovation, and,entrepreneurship in ...
... exemplify perseverance, ST. LOUIS, July 16 There,s ... their votes. They can vote online,and vote now for ... to elect,a new member of the 2008 Energizer(R) Keep ... of Fame celebrates everyday people whose,attributes and actions best ...
... 26 Grand Opening Festivities Will Include Health Education Fair,Tour ... "9 Steps to Optimum,Health", HUNTERSVILLE, N.C., July 16 ... is dedicated to successfully treating,diseases that were previously thought ... level of health, today announced that it will open,the ...
Cached Medicine News:Health News:Assurant Health Names Jennifer Kopps-Wagner Senior Vice President and General Counsel 2Health News:Stereotaxis Magnetic Navigation System Used to Successfully Treat an Inoperable Congenital Heart Defect in a 10-Year Old Patient 2Health News:Stereotaxis Magnetic Navigation System Used to Successfully Treat an Inoperable Congenital Heart Defect in a 10-Year Old Patient 3Health News:The Crisis in State and Local Government Retiree Health Benefit Plans: Myths and Realities 2Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 2Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 3Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 4Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 5Health News:North Carolina's Center For Advanced Medicine & Clinical Research Celebrates Opening of New LKN Medical Spa and Rejuvenation Center 2Health News:North Carolina's Center For Advanced Medicine & Clinical Research Celebrates Opening of New LKN Medical Spa and Rejuvenation Center 3
(Date:8/22/2014)... 2014 Research and Markets  has announced ... Opportunities, Tools & Technologies" report to their offering. ... research products or you wish to expand your product ... market is. The authors know you want to make ... scientists, to generate improved revenues and take market share ...
(Date:8/22/2014)... Aug. 22, 2014 MC Medical, a subsidiary of ... Columbus, OH medical device company, have ... laparoscopic and robotic visualization system in Japan ... sale in Japan in the latter ... and an extensive product portfolio in endoscopic surgery market in ...
(Date:8/22/2014)... , Aug. 22, 2014   Zacks Equity Research highlights ... of the Day and Panera (Nasdaq: PNRA - Free Report ... Research provides analysis on Amicus Therapeutics (Nasdaq: FOLD - Free ... Shire (Nasdaq: SHPG - Free Report ). Here ... Bull of the Day : The biotech bull ...
Breaking Medicine Technology:Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 2Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 3MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6
... is the most common cause ... 5% of pediatric visits and ... under 5 years. ImmunoSTAT! Rotatvirus ... rule in or rule out ...
The CdTOX A OIA gets the results you need without specimen extraction or instrumentation. Results are available in minutes vs hours or days for EIA or other methods. The combination of performance, ...
... Ideal for Botox therapy and ... stainless steel injectable needle has a ... touchproof connector with an attached 61-cm ... for easy insertion. Single patient use ...
... Back Relief Apron has standard ... the weight from the shoulders ... aid of a 6" wide ... strap keeps apron snug. Belts ...
Medicine Products: