Navigation Links
Smokers might benefit from earlier colon cancer screening

New evidence suggests screening for colorectal cancer, which is now recommended to begin at age 50 for most people, should start five to 10 years earlier for individuals with a significant lifetime exposure to tobacco smoke, a University of Rochester Medical Center study said.

An examination of 3,450 cases found that current smokers were diagnosed with colon cancer approximately seven years earlier than people who never smoked. The study is also one of the first to link exposure to second-hand smoke, especially early in life, with a younger age for colon cancer onset.

The article appears online in the Journal of Cancer Research and Clinical Oncology.

The message for physicians and patients is clear: When making decisions about colon cancer screening you should take into account smoking history as well as family history of disease and age, said lead author Luke J. Peppone, Ph.D., research assistant professor of Radiation Oncology at the James P. Wilmot Cancer Center at the University of Rochester.

Peppones group examined data from patients diagnosed with colorectal cancer between 1957 and 1997 at Roswell Park Cancer Institute in Buffalo. (Peppone joined the University of Rochester in 2007, coming from RPCI. Co-authors are from RPCI.)

Over the 40-year period smoking habits changed, with a decrease in the percentage of current or active smokers and an increase in the percentage of former smokers. Still, the age at colon cancer diagnosis was 6.8 years younger among current smokers and 4.3 years younger for former smokers who quit less than five years ago, the results showed. People who quit more than five years ago had no significant increased risk.

However, people who reported they began smoking as young teens (before age 17) or who smoked heavily (1 pack a day or more) were the most likely to be diagnosed with cancer much younger than their never-smoking counterparts. Past exposure to second-hand-smoke was an additional, significant risk factor, compared to never smoking. In fact, when active smokers and passive smoking were combined into one subgroup, the age at cancer diagnosis was nearly 10 years earlier, Peppone said.

Although smoking is a well-known risk factor for many cancers, only recent studies have suggested that cigarettes may cause colon cancer.

The biological reasons for the cigarette smoke-colon cancer risk are unclear. However, researchers believe that cigarette smoke reduces the bodys resistance to malignancies, just as smoking can depress immune function in general, impairing the ability to fight off infections and viruses. Carcinogens from smoke reach the bowel through direct circulation or by swallowing smoke and passing it through the intestines.

Colorectal cancer is the third most commonly diagnosed cancer among men and women. Genetics account for about 10 percent of new cases, the study said, while more than 75 percent of the cases arise from sporadic mutations and/or environmental and lifestyle factors such as smoking, a poor diet, alcohol use, lack of exercise and obesity.


Contact: Leslie Orr
University of Rochester Medical Center

Related medicine news :

1. Teens who see more smoking in movies may have increased risk of becoming established smokers
2. Smokers More Likely to Develop Dementia
3. Help is Available for Smokers Who Want to Quit as Minnesotas Smoke-Free Law Takes Effect Oct. 1
4. First Puff Can Turn Kids Into Smokers: Study
5. Statins reduce loss of function, keeping old lungs young - even in smokers
6. Blood Test Catches Secret Smokers
7. Smokers Remain Unaware of the Health Effects of Smoking, New Survey Finds
8. Smokers Cost Medicaid System Nearly $10 Billion
9. Studies of 20,000 smokers show quit rates double with counseling and free nicotine patches
10. Smoking Cessation Rates Double With Intensive Counseling and Free Nicotine Replacement Therapy, Studies of 20,000 Smokers Show
11. FSU researcher lands $3.3 million grant to help smokers kick habit
Post Your Comments:
(Date:11/26/2015)... ... 26, 2015 , ... Patients at Serenity Point Recovery, a ... on Thanksgiving Day to share the things that they are most grateful for ... YouTube channel, patients displayed what they wrote on index cards, describing the things ...
(Date:11/26/2015)... ... ... The Catalent Applied Drug Delivery Institute today announced a ... selection in early phase drug development. The first of these is to be ... UK’s emerging life sciences companies, corporate partners, and investors, at Milton Park, Oxford, ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel ... self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with ... work with any font, giving users limitless opportunities to stylize and create designs ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... Water For Empowerment ™ attracts volunteers together who want to combine talents ... women as key stakeholders in the process. The non-profit launched its first major ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... direct sauna parts and accessories. , Sauna accessories help improve the bather experience ... and personality. From basic styles for the purist looking for simplicity in design ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 ) has ... of High Viscosity Drugs" report to their ... the addition of the "Self Administration of ... --> Research and Markets ( ... "Self Administration of High Viscosity Drugs" report ...
(Date:11/25/2015)... , Nov. 25, 2015 ... addition of the "Global Brain Monitoring ... offering. --> ) has ... Brain Monitoring Devices Market 2015-2019" report ... and Markets ( ) has announced ...
(Date:11/25/2015)... WOODBURY, N.Y. , Nov. 25, 2015  Linden ... access and optimizing treatment outcomes for patients suffering from ... its request for a Temporary Restraining Order (TRO) enjoining ... between the two companies. --> ... aggressively pursuing all of its legal options. ...
Breaking Medicine Technology: