Navigation Links
Smoked cannabis reduces chronic pain
Date:8/29/2010

For people suffering chronic pain, smoked cannabis reduces pain, improves mood and helps sleep, according to new research published in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj091414.pdf.

People who suffer from chronic neuropathic pain due to damage or dysfunction of the nervous system have few treatment options. These options include opioids, anticonvulsants, antidepressants and local anesthetics, but efficacy varies and all have side effects which limit compliance. Oral cannabinoids have shown success in treating some types of pain but may differ in effect and risks from smoked cannabis.

A team of researchers from McGill University Health Centre (MUHC) and McGill University conducted a randomized controlled trial to investigate the analgesic effect of inhaled cannabis in 21 participants 18 years and older with chronic neuropathic pain. The researchers used three different potencies of active drug (THC levels of 2.5%, 6% and 9.4%) as well as a 0% placebo.

Patients reported better sleep quality as the THC content increased. Anxiety and depression also decreased in the 9.4% THC group compared with the placebo group.

"We found that 25 mg herbal cannabis with 9.4% THC, administered as a single smoked inhalation three times daily for five days, significantly reduces average pain intensity compared with a 0% THC cannabis placebo in adult subjects with chronic post traumatic/post surgical neuropathic pain," reports lead author Dr. Mark Ware, Director of Clinical Research at the Alan Edwards Pain Management Unit of the MUHC. "We found statistically significant improvements in measures of sleep quality and anxiety."

"To our knowledge, this is the first outpatient clinical trial of smoked cannabis ever reported," the authors state. It is one of only a handful of studies on smoked cannabis and neuropathic pain. The authors recommend more studies with higher potencies of THC, longer duration of follow-up and flexible dosing. Long-term safety studies of smoked cannabis for medical purposes are also needed.

In a related commentary http://www.cmaj.ca/embargo/cmaj100799.pdf, Dr. Henry McQuay of Balliol College, Oxford University, UK, writes "the authors should be congratulated for tackling such a worthwhile question as: does cannabis relieve neuropathic pain?, particularly because the trial must have been a major nightmare to get through the various regulatory hurdles. What makes it a worthwhile question is the continuing publicity that patients see, hear and read, suggesting analgesic activity of cannabis in neuropathic pain, and the paucity of robust evidence." He concludes that "this trial adds to the trickle of evidence that cannabis may help some of the patients who are struggling at present."


'/>"/>

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116 x2224
Canadian Medical Association Journal
Source:Eurekalert

Related medicine news :

1. MarijuanaDoctors.com Announces Weed Team Contest Winner, Adds Additional Trip to the Cannabis Cup in Amsterdam
2. Cannabis Medical Solutions Announces Plan to Franchise Ownership of Medical Marijuana Dispensaries in California
3. Service Foods Reduces its Carbon Footprint and Grows Sales
4. Health Care Reform Report Covers Uninsured, Reduces Costs
5. New cardiac CT technology drastically reduces patient radiation exposure
6. Accelerated radiation therapy reduces toxicity in patients with advanced head and neck cancers
7. Targeted delivery of losartan reduces liver inflammation and scarring
8. Drug dramatically reduces nausea and vomiting in bone marrow transplant patients
9. Soccer reduces risk of falls and bone fractures
10. Pioneering treatment reduces disability in premature babies with serious brain hemorrhage
11. New drug candidate reduces blood lipids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... , ... Tuesday, May 24, Women's Excellence in Wellness, powered by Movestrong will ... Oils, taught by Patti Dolan, RYT, a Young Living Gold Member. The class ... - 7:15pm followed by a small intro to the Oils that can benefit the ...
(Date:5/24/2016)... , ... May 24, 2016 , ... In light of ... aware of the potential of contaminated well water throughout the Houston area. , Heavy ... with well water that’s exposed to contaminants. Residents may not even be aware of ...
(Date:5/24/2016)... ... May 24, 2016 , ... "ProText Layouts Vol. 3 ... Austin - CEO of Pixel Film Studios. , ProText Layouts Vol. 3 is a ... Cut Pro X . With ProText Layouts, video editors can create an lively typography ...
(Date:5/24/2016)... , ... May 24, 2016 , ... After graduating from ... spent the next decade in hospitals, on medication, living on Social Security disability and ... the Illness and How I Beat It!” (published by Balboa Press), Alexander shares how ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... highly anticipated, web-based software module. The cutting-edge feature provides end users with ... with Izenda’s self-service business intelligence solution and its analytics engine. , ...
Breaking Medicine News(10 mins):
(Date:5/20/2016)... , May 20, 2016 ... Pipeline Review, H1 2016" market research report with ... Psoriasis (Psoriasis Vulgaris), complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ... news and press releases. It also reviews key ...
(Date:5/19/2016)... , May 19,2016 Cellvizio ... Digestive Disease Week Meeting and 91 st ... Mauna Kea Technologies (Euronext: MKEA, OTCQX: MKEAY) ... platform, today announced that its Cellvizio platform is ... on gastroenterology during the month of May. The ...
(Date:5/19/2016)... 2016 According to a new market research ... (U.S., Germany , France , ... and Japan )", published by MarketsandMarkets, The market ... CAGR of 13.9% from 2016 to 2021.      (Logo: ... data Tables spread through 26 Pages and in-depth TOC on ...
Breaking Medicine Technology: