Navigation Links
Smoked cannabis reduces chronic pain
Date:8/29/2010

For people suffering chronic pain, smoked cannabis reduces pain, improves mood and helps sleep, according to new research published in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj091414.pdf.

People who suffer from chronic neuropathic pain due to damage or dysfunction of the nervous system have few treatment options. These options include opioids, anticonvulsants, antidepressants and local anesthetics, but efficacy varies and all have side effects which limit compliance. Oral cannabinoids have shown success in treating some types of pain but may differ in effect and risks from smoked cannabis.

A team of researchers from McGill University Health Centre (MUHC) and McGill University conducted a randomized controlled trial to investigate the analgesic effect of inhaled cannabis in 21 participants 18 years and older with chronic neuropathic pain. The researchers used three different potencies of active drug (THC levels of 2.5%, 6% and 9.4%) as well as a 0% placebo.

Patients reported better sleep quality as the THC content increased. Anxiety and depression also decreased in the 9.4% THC group compared with the placebo group.

"We found that 25 mg herbal cannabis with 9.4% THC, administered as a single smoked inhalation three times daily for five days, significantly reduces average pain intensity compared with a 0% THC cannabis placebo in adult subjects with chronic post traumatic/post surgical neuropathic pain," reports lead author Dr. Mark Ware, Director of Clinical Research at the Alan Edwards Pain Management Unit of the MUHC. "We found statistically significant improvements in measures of sleep quality and anxiety."

"To our knowledge, this is the first outpatient clinical trial of smoked cannabis ever reported," the authors state. It is one of only a handful of studies on smoked cannabis and neuropathic pain. The authors recommend more studies with higher potencies of THC, longer duration of follow-up and flexible dosing. Long-term safety studies of smoked cannabis for medical purposes are also needed.

In a related commentary http://www.cmaj.ca/embargo/cmaj100799.pdf, Dr. Henry McQuay of Balliol College, Oxford University, UK, writes "the authors should be congratulated for tackling such a worthwhile question as: does cannabis relieve neuropathic pain?, particularly because the trial must have been a major nightmare to get through the various regulatory hurdles. What makes it a worthwhile question is the continuing publicity that patients see, hear and read, suggesting analgesic activity of cannabis in neuropathic pain, and the paucity of robust evidence." He concludes that "this trial adds to the trickle of evidence that cannabis may help some of the patients who are struggling at present."


'/>"/>

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116 x2224
Canadian Medical Association Journal
Source:Eurekalert

Related medicine news :

1. MarijuanaDoctors.com Announces Weed Team Contest Winner, Adds Additional Trip to the Cannabis Cup in Amsterdam
2. Cannabis Medical Solutions Announces Plan to Franchise Ownership of Medical Marijuana Dispensaries in California
3. Service Foods Reduces its Carbon Footprint and Grows Sales
4. Health Care Reform Report Covers Uninsured, Reduces Costs
5. New cardiac CT technology drastically reduces patient radiation exposure
6. Accelerated radiation therapy reduces toxicity in patients with advanced head and neck cancers
7. Targeted delivery of losartan reduces liver inflammation and scarring
8. Drug dramatically reduces nausea and vomiting in bone marrow transplant patients
9. Soccer reduces risk of falls and bone fractures
10. Pioneering treatment reduces disability in premature babies with serious brain hemorrhage
11. New drug candidate reduces blood lipids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... June 26, 2017 , ... If the devil is in ... red these days. According to recent estimates, 75 – 80% of the medical ... Some studies point to Electronic Health Records (EHR) with automated features designed to ...
(Date:6/25/2017)... CA (PRWEB) , ... June 24, 2017 , ... Create a feel-good lyric music video ... above footage and sound in the timeline and write in the lyrics to any song. ... flying back out. Each line of the text can be added modularly for optimal control. ...
(Date:6/25/2017)... , ... June 25, 2017 , ... With a heatwave currently bearing down on Northern ... out at the pool. Being swimsuit ready is easy with laser hair removal. , ... again can be a burdensome routine when all you want to do is get out, ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. ... 217 Portion Road in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine ... visits to the dentist fit into their patients’ busy lifestyles. Dental365 also gladly ...
(Date:6/23/2017)... ... June 23, 2017 , ... "The Better Care Reconciliation ... significant harm to people with all chronic conditions, including mental illnesses, while increasing ... place the Affordable Care Act (ACA) requirement that insurers cover pre-existing conditions, it ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... , June 7, 2017  Novavax, Inc., (Nasdaq: ... two Phase 2 trials of its RSV F protein recombinant ... bearing age have been published in the journal ... been shared in prior scientific conferences). The Company previously announced ... 2014. Novavax is developing the RSV F Vaccine with the ...
(Date:6/5/2017)... -- The Cincinnati location of Diplomat ... DPLO), has been awarded a Top Workplaces 2017 ... are based on an employee survey administered by WorkplaceDynamics, LLC, ... The survey measures several aspects of workplace culture, including alignment, ... ...
(Date:6/3/2017)... , June 3, 2017  Eli Lilly ... announced that results from the Phase 3 MONARCH ... (CDK)4 & 6 inhibitor, in combination with fulvestrant, ... with fulvestrant alone in women with hormone-receptor-positive (HR+), ... breast cancer who have relapsed or progressed after ...
Breaking Medicine Technology: