Navigation Links
Smart lasers could make cancer biopsies painless, help speed new drugs to market

EAST LANSING, Mich. Biopsies in the future may be painless and noninvasive, thanks to smart laser technology being developed at Michigan State University.

To test for skin cancer, patients today must endure doctors cutting away a sliver of skin, sending the biopsy to a lab and anxiously awaiting the results. Using laser microscopes that deploy rapid, ultra-short pulses to identify molecules, doctors may soon have the tools to painlessly scan a patient's troublesome mole and review the results on the spot, said Marcos Dantus.

The results touting this new molecule-selective technology can be found in the current issue of Nature Photonics, which Dantus co-authored with Sunney Xie of Harvard University.

"Smart lasers allow us to selectively excite compounds even ones with small spectroscopic differences," said Dantus. "We can shape the pulse of the lasers, excite one compound or another based on their vibrational signatures, and this gives us excellent contrast."

In the past, researchers could approach this level of contrast by introducing fluorescent compounds. With the breakthrough using stimulated Raman scattering microscopy, fluorescent markers are unnecessary.

"Label-free molecular imaging has been the holy grail in medicine," Dantus said. "SRS imaging gives greater specificity and the ability to map a particular chemical species in the presence of an interfering species, such as cholesterol in the presence of lipids."

Additional potential applications include allowing researchers to closely examine how compounds penetrate skin and hair. Smart lasers also can better identify how drugs penetrate tissue and how drugs and tissue interact, thus mitigating the chances of potential side effects and helping reduce the time required to bring new drugs to market.

Dantus also is using smart laser imaging technology at MSU for detecting traces of hazardous substances from a distance.

"The ability to image with molecular specificity and sensitivity opens a number of applications in medicine as well as in homeland security," he said.

Collaboration for the paper began when Harvard graduate student Christian Freudiger contacted BioPhotonic Solutions, a high-tech company Dantus launched in 2003 based on his research at MSU. Dantus was not only able to provide the laser pulse shaper Harvard needed to conduct the research, but he also was able to lend his expertise as well as the support of his MSU laboratory, Dantus said.

"I like to say that we enable technology," he said. "Controlling ultrashort pulses, which once required Ph.D. experts, can now be done with push-button simplicity by a small computer-controlled box. This instrument is now being used in the most prestigious research laboratories in the world."


Contact: Layne Cameron
Michigan State University

Related medicine news :

1. How to Get Smart About Weight Loss
2. Your Dog May Be Smarter Than You Know
3. Smarter systems help busy doctors remember
4. Smarten Up About Antibiotics, CDC Urges
5. Smart drug targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
6. 70-year-olds smarter than they used to be
7. Outsmarting killer bacteria
8. Mayos smart adult stem cells repair hearts
9. HealthSmart Adds Experienced Professionals to Houston Sales Force
10. HealthSmart Hosts First Forum on National Healthcare Reform and Trends
11. Tyco Electronics Demonstrates Passion For Smart Networking At CISCO Live! 2010
Post Your Comments:
(Date:11/25/2015)... ... , ... Beddit® has launched a new Android app for use ... a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and makes ... by a proprietary algorithm. Beddit analyzes the data to provide an easy to understand ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... provide scholarships for people struggling with eating disorders as a result of the ... second annual event, held at Fox Run Golf Club in Eureka, will help ...
(Date:11/25/2015)... ... 2015 , ... Many people know of the common symptoms of low thyroid ... skin. But many people who find their cholesterol levels and weight are creeping up ... especially if they don’t have any of the other symptoms. , Thyroid hormone plays ...
(Date:11/24/2015)... ... 2015 , ... Genesis Chiropractic Software helps practice owners automate ... between the practice owner and the patient that automatically manages all five aspects ... Click here to learn more. , According to Dr. Brian ...
(Date:11/24/2015)... Dallas, Texas (PRWEB) , ... November 24, 2015 , ... ... of all charitable donations are made in the last five weeks of the year ... #GivingTuesday was created in 2012 to connect the nation’s charities with those individuals who ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 Research and Markets ( ) ... - Global Forecast to 2020" report to their ... for 37.21% of the total market share in 2014. ... region is projected to growth at the highest CAGR ... primarily to the fast growing water, industrial gas treatment, ...
(Date:11/24/2015)... 25, 2015 WuXi PharmaTech (Cayman) Inc. ("WuXi" ... open-access R&D capability and technology platform company serving the ... China and the ... extraordinary general meeting of shareholders held today, the Company,s ... and approve the previously announced agreement and plan of ...
(Date:11/24/2015)... N.C. , Nov. 24, 2015  In the ... projects in an effort to quickly uncover new insights, ... --> --> However, ... a market research project and ensure that all rules ... and industry standards. Another major barrier to efficiently launching ...
Breaking Medicine Technology: