Navigation Links
Smart insulin nanostructures pass feasibility test, UT study reports

HOUSTON -- (Sept. 18, 2007) -- Biomedical engineers at The University of Texas School of Health Information Sciences at Houston have announced pre-clinical test results in the September issue of the International Journal of Nanomedicine demonstrating the feasibility of a smart particle insulin release system that detects spikes in glucose or blood sugar levels and releases insulin to counteract them.

Designed to mimic functions of the pancreas which produces the blood-sugar regulating hormone insulin, the smart particle system stabilized blood sugar levels in animal models with suppressed pancreatic functions for up to six hours, researchers reported. It is an inhalable system.

The study, Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats, was conducted in the laboratory of Ananth V. Annapragada, Ph.D., an associate professor at the UT School of Health Information Sciences. Research assistant Efstathios Karathanasis was lead author and postdoctoral fellow Rohan C. Bhavane was a contributor on the article.

The smart particle system consists of a blood sugar sensing protein named concanavalin A (Con A) and bundles of tiny fat bubbles called liposomes that are loaded with insulin. Con A binds insulin-containing liposomes that are coated with sugars, to each other, to form the inhaled particles, Annapragada said. When blood sugar becomes present, the Con A releases the particles to bind independently to the sugars. The released particles then release their insulin.

Hundreds of thousands of individuals suffer Type I diabetes, a condition that develops when the bodys immune system destroys pancreatic beta cells the only cells that make insulin. High blood sugar levels can lead to serious complications and premature death.

No one had ever shown that an inhalable smart release system was viable, said Annapragada, who describes the study as a proof of concept initiative. He said additional work including the discovery of less inflammatory blood sugar sensing proteins or small molecules will be required before its efficacy for patients can be tested in clinical trials.

The smart particle system could potentially treat other health conditions, he said.


Contact: Rob Cahill
University of Texas Health Science Center at Houston

Related medicine news :

1. Smart Plastic As Surigical Thread
2. Music Makes you Smarter
3. An Anti-cancer Smart Bomb delivered using a Nanocell
4. Smart drugs for alcohol hangovers not effective
5. Need For Smarter Ways To Identify Fake Drugs & Internet Counterfeiting: WHO
6. Nurses Outsmart Surgeons When It Comes Safety And Team Wok
7. Goodbye, Blue Smarties
8. Government Considering Of Issuing ‘Smart Cards’ For HIV/AIDS Patiens
9. Sex Workers To Have Smart Health Card
10. Snack Smart To Avoid Obesity
11. Smart Beds Could Help to Prevent Elderly Patients from Falling
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... In honor of Pulmonary Hypertension ... and groups responsible for advancing care for pulmonary hypertension (PH) patients and helping ... public, will receive special recognition throughout 2016 as part of PHA’s 25th anniversary ...
(Date:11/25/2015)... ... 25, 2015 , ... Bcureful—a non-profit organization devoted to advancing ... public awareness of the disorder while helping to bring expert medical care and ... bolster progress at the Tuberous Sclerosis Complex Center at Ann & Robert H. ...
(Date:11/24/2015)... ... 2015 , ... Eric C. Seidel, DMD and Stephanie DeFilippo, ... revolutionary BIOLASE WaterLase iPlus 2.0™ system. This advanced laser technology uses light energy ... dentist in Gettysburg, PA . From routine visits to cosmetic treatments, laser dentistry ...
(Date:11/24/2015)... CA (PRWEB) , ... November 24, 2015 , ... ... sizes, has launched their Black Friday sale a week early, offering 40% off ... to transform the intimate apparel industry through both mobile fit technology and the ...
(Date:11/24/2015)... ... ... Preparing for the LDT Regulation:, CLIA Won’t Satisfy the FDA, Dec. ... has long asserted that design and manufacture of Laboratory Developed Tests (LDTs) falls under ... the device regulations. , Come up short in an inspection and the FDA can ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... Investors"), pursuant to which BioLight and the New Investors ... Ltd. subsidiary ("IOPtima") via a private placement. The financing ... its innovative IOPtimate™ system used in the treatment of ... pathway process for the IOPtimate™ system with the U.S. ...
(Date:11/25/2015)... 2015 Developmental, commercial, and regulatory/legal ... profitability of pharmaceutical products, says GBI Research ... regulatory/legal strategies all play a key role in boosting ... . --> Developmental, commercial, ... in boosting the profitability of pharmaceutical products, says ...
(Date:11/25/2015)... Research and Markets ( ) has ... Global Forecast to 2020" report to their offering. ... 37.21% of the total market share in 2014. The ... is projected to growth at the highest CAGR between ... to the fast growing water, industrial gas treatment, pharmaceutical, ...
Breaking Medicine Technology: