Navigation Links
'Smart drug' targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
Date:10/27/2010

BOSTON--A new oral drug caused dramatic shrinkage of a patient's rare, aggressive form of soft-tissue cancer that was driven by an abnormally activated protein, physician-scientists from Dana-Farber Cancer Institute report in the Oct. 28 issue of the New England Journal of Medicine.

A second patient who had a similar tumor that was not fueled by the mutant protein, called ALK (named for the first disease in which it was found, anaplastic lymphoma kinase), failed to respond to the drug, said the researchers, confirming the inhibitor's specificity for the abnormal protein. The findings also highlight the value of "personalized medicine" gene-testing strategies to predict the best drug treatment for an individual's particular, genetically defined cancer.

The patient described in the NEJM Brief Report is a 44-year-old man diagnosed in 2007 with inflammatory myofibroblastic tumor (IMT), a type of sarcoma that typically develops in the chest or abdomen in children and young adults.

In approximately half the cases of IMT, ALK is fused to a different protein in the patients' cancer cells, spurring cancer development. The patient had been treated with standard chemotherapy drugs followed by the targeted compound Gleevec, but the cancer returned in the form of multiple tumors.

James Butrynski, MD and Geoffrey Shapiro, MD, PhD, Dana-Farber oncologists and the first and senior authors of the report, respectively, offered the patient participation in a Phase 1 trial of an experimental drug, crizotinib, which blocks ALK activity, as well as that of another oncogene, MET, that is abnormally activated in a number of cancers.

Crizotinib treatment shrank the tumors by more than 50 percent technically called a "partial response." After several months of crizotinib, in December 2008, some of the tumors became resistant to the drug and started growing again. These tumors, as well as tumors still responsive to crizotinib, were
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Cook With Love This Valentines Day With Heart-Smart Recipes
2. ANT+ and Texas Instruments connect proven ultra low power sensors to smartphones
3. Hollywood-Style Liposuction Comes to DC: Chevy Chase Smartlipo Brings Revolutionary Laser-Assisted Liposuction to DC Metro Area
4. Afternoon Nap Might Make You Smarter
5. State of Oregon Department of Human Services Selects Netsmart Technologies for Comprehensive Behavioral Healthcare Integration Project
6. SSI Announces Its Fourth Generation Revenue Cycle Management Technology, ClickON ClaimSmart Suite
7. Brain Cancer Survivor Will Cycle 4,170 Miles Across USA to Outsmart Disease
8. Conference Focuses on Aligning Two Smartest, Most Expensive Operations
9. SDI Reports: Nearly a Third Of Physicians Use Handheld and Smartphone Devices to Access Medical Information - Physicians Most Likely to be Using Apple iPhone
10. Smart Balance to Present at Roth Growth Stock Conference
11. PA Hypnosis Center Uses 'Smart Training' Sports Psychology for Gold Medal Success
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Smart drug' targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer
(Date:9/3/2015)... , ... September 03, 2015 , ... ... for its upcoming virtual conference, “Proven Pharmacy Benefit Strategies for a Rapidly Changing ... CVS Health, Express Scripts and Milliman, will discuss how plan sponsors are adopting ...
(Date:9/3/2015)... ... 2015 , ... Hunters Creek Retrievers is again honored to salute ... Lab Puppy. Celebrate Fall 2015 with unlimited Free Hugs and K9 Kisses from a ... and Christmas with an extra big smile. , This adorable trained Lab Pup ...
(Date:9/3/2015)... ... September 03, 2015 , ... ProScrub is a set ... & forth, flicker, repeat, and custom speed effects without the use of keyframes. ... of effect. ProScrub tools are perfect complements to energetic video productions. ProScrub ...
(Date:9/3/2015)... ... September 03, 2015 , ... A scar is an unavoidable result of incision or ... of the body's ability to heal itself. The appearance of a scar is dependent on ... age, genes, and skin pigmentation. ”Many scars fade to near invisibility on their own over ...
(Date:9/3/2015)... ... September 03, 2015 , ... “Love in Tokyo” an independent romantic ... , and Amazon and will be released on DVD early next year, ... a Foreigner,” Itsuka, an actress and singer/songwriter, and Jason London, lead from “Dazed and ...
Breaking Medicine News(10 mins):Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2Health News:Hunters Creek Retrievers Is Honored to Support the Lone Survivor Foundation with a Championship Trained Black Labrador Retriever Puppy 2Health News:Hunters Creek Retrievers Is Honored to Support the Lone Survivor Foundation with a Championship Trained Black Labrador Retriever Puppy 3Health News:FCPX Effects Developer Releases ProScrub for Final Cut Pro X 2Health News:Do I Have To Live With That Scar? 2Health News:Do I Have To Live With That Scar? 3Health News:Do I Have To Live With That Scar? 4Health News:The Romantic Comedy Film "Love in Tokyo" Has Been Released on ITunes, Google Play, and Amazon 2
... The Danone Baby Nutrition and Medical Nutrition Divisions ... Zoetermeer, the Netherlands, as the winner of their 2008 ... a supplier-of-the-year award and is given for overall performance ... during 2008," said Rafael Fernandez, business unit vice president ...
... FOR IMMEDIATE RELEASE , Improving rural sanitation by ... lives a year worldwide, scientists in Pennsylvania conclude in ... the current edition of ACS, semi-monthly journal Environmental ... Africa and Asia would experience the greatest savings in ...
... implementable technique to avoid reblockage of arteries that have ... developed by researchers led by Prof. Boris Rubinsky of ... is the "gold-standard" treatment for acute myocardial infarction (heart ... blood supply to part of the beating heart, usually ...
... Health Care Reform, Received More Industry Contributions Than ... and pharmaceutical manufacturers contributed $5.5 million to the ... House of Representatives during the last two election ... reform dominated political discourse, according to the nonprofit, ...
... Journal of Radiation Oncology*Biology*Physics Study Finds that ... Image Information for Planning Partial Breast Irradiation ... the February 1st issue of the International ... of 3D ultrasound with the Clarity(TM) Breast ...
... brochures with National Osteoporosis FoundationCHICAGO, March 9 ... by recent news reports about how osteoporosis medications ... brochure to help them separate fact from fiction. ... National Osteoporosis Foundation to create the brochure, "Osteoporosis ...
Cached Medicine News:Health News:Graham Packaging On-Site Plant in Zoetermeer Wins Top Performance Award From The Danone Baby Nutrition and Medical Nutrition Divisions 2Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 2Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 3Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 4Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 5Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 6Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 7Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 8Health News:American Chemical Society's Weekly PressPac -- March 4, 2009 9Health News: Hebrew University scientist develop technique for eliminating reblockage of arteries 2Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 2Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 3Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 4Health News:Consumer Watchdog: Health Insurers & Drug Companies Contributed $5.5 Million to Top 10 Senate and House Recipients Since 2005 5Health News:Published Data Confirms First 3D Ultrasound for Breast Cancer Treatment Planning Helps Radiation Oncologists Better Define Treatment Region 2Health News:Published Data Confirms First 3D Ultrasound for Breast Cancer Treatment Planning Helps Radiation Oncologists Better Define Treatment Region 3Health News:Published Data Confirms First 3D Ultrasound for Breast Cancer Treatment Planning Helps Radiation Oncologists Better Define Treatment Region 4Health News:ADA Informs Patients About Osteoporosis Medications and Oral Health 2Health News:ADA Informs Patients About Osteoporosis Medications and Oral Health 3
(Date:9/3/2015)... and REHOVOT, Israel, Sept. 3, 2015 OticPharma, ... developing innovative therapies for ear, nose, and throat (ENT) ... Newport Gateway office complex to be the location of ... move by end of September and will have office ... Headquarters: OticPharma, Inc. 19900 MacArthur Blvd., Suite ...
(Date:9/2/2015)... Sept. 2, 2015 About ... of one or more vertebral bodies, resulting in ... degenerative bone disease, is a leading cause of ... myeloma, metastatic spinal tumors, and traumatic injuries also ... and kyphoplasty to rectify the condition. Both procedures ...
(Date:9/2/2015)... YORK , Sept. 2, 2015 ... market studies the current and future prospects of ... of patient,s health and assists medical practitioners in ... the disease progression during treatment. Multi-parameter patient monitoring ... and chronic disease. Geriatric population is observed to ...
Breaking Medicine Technology:OticPharma Establishes U.S. Headquarters in Orange County, California 2Global Balloon Kyphoplasty Market 2015-2019 2Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 2Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 3
... Watson Pharmaceuticals, Inc. (NYSE: WPI ), a ... Watson,s President and Chief Executive Officer, will provide an ... 2011 Goldman Sachs 32nd Annual Global Healthcare Conference on ... the Terranea Resort in Rancho Palos Verdes, California. The ...
... 1, 2011 For 30 years, the national survival ... low six percent. Recognizing the need for expanded awareness ... Cardiac Arrest Association (SCAA) is donating 30 life-saving automated ... country as part of the Association,s "donAtED 2011" program. ...
Cached Medicine Technology:SCAA Puts the 'AED' in CPR/AED Week to Make Communities Safer, Better Equipped to Respond to Cardiac Arrest 2SCAA Puts the 'AED' in CPR/AED Week to Make Communities Safer, Better Equipped to Respond to Cardiac Arrest 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: