Navigation Links
Smaller radiation fields can spare brain when treating tumors, Wake Forest Baptist research finds
Date:1/9/2013

WINSTON-SALEM, N.C. Jan. 9, 2013 New research from Wake Forest Baptist Medical Center shows that patients suffering from aggressive brain tumors can be effectively treated with smaller radiation fields to spare the rest of the brain and preserve cognition.

"For patients with glioblastoma, we now know we can safely and effectively treat them with smaller radiation fields to spare the rest of their normal brain," said lead investigator Michael D. Chan, M.D., assistant professor of radiation oncology at Wake Forest Baptist. "That's important because it lessens the symptoms from radiation toxicity like tiredness and nausea."

Chan said that a patient's cognition is related to how much normal brain is irradiated so focusing radiation on smaller areas of the brain may help preserve cognition and does not seem to lead to an increase in the likelihood of the tumor recurring. Overall, while long-term survival rates for glioblastoma multiforme patients have not improved by much with treatment advances, the ability to treat with smaller radiation fields preserves cognition and provides the possibility of better quality of life.

Recent research findings from Chan and colleagues appeared online last month ahead of print in the American Journal of Clinical Oncology. While there have been other similar studies, this one is the largest to compare smaller radiation margins to larger ones to document differences in patterns of failure for patients, Chan said. For this retrospective study, records for 161 patients treated at Wake Forest Baptist over the last 10 years were reviewed.

"We decided a few years ago that it would be worthwhile to look at whether using these tighter margins would affect the tumors coming back outside of the radiation field, or tell us if we are barely missing," Chan said. "We are the first to show definitively that people with smaller margins don't do any worse than those with larger margins."

Chan said that in the 1990s, Wake Forest Baptist's Edward G. Shaw, M.D., professor of radiation oncology, was part of a group that pioneered using smaller margins because it was less toxic. Smaller radiation margins around the tumor do not seem to lead to an increase in the tumor returning just outside of the radiation field, Chan said. A smaller radiation field, combined with modern treatment techniques, like newer chemotherapy agents and radiation technologies, provides physicians with more options.

"Treatments have gotten better over time and people with GBM may live longer than they had in the past. Our study found that the margins did not affect where the GBM came back or how long it took it to come back and it did not affect the overall survival," Chan said. "This could potentially be practice changing."


'/>"/>

Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Babies born to mothers from the Philippines significantly smaller than those of Canadian-born women
2. Standing at Work All Day While Pregnant Linked to Smaller Babies
3. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
4. Radiation Research Society honors 2 faculty
5. Immediate health risk must be weighed against radiation-induced cancer risk
6. Berkeley Lab scientists developing quick way to id people exposed to ionizing radiation
7. ‘A Subtle Addiction – Attacking the Y Generation’ - New Book by Peter & Lynn McIntosh Begs the Question "Is an Ipad, Kindle or Smart Phone a Safe Gift or a Potential Radiation Cancer Risk this Holiday Season?"
8. ‘A Subtle Addiction – Attacking the Y Generation’ the New Book by Peter and Lynn McIntosh Discusses Cell Phone Radiation - are Parents Nuking their Kids this Christmas?
9. Cell Phone Radiation Lawsuit Update: ICEMS Position Paper Supports Italian Supreme Court Ruling on Cell Phones and Brain Tumors, Bernstein Liebhard LLP Reports
10. More U.S. Kids Get High-Radiation Scans, Study Says
11. Experts recommend closer scrutiny of radiation exposure from CT scans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: